Tags

Type your tag names separated by a space and hit enter

Multiple ciguatoxins in the flesh of fish.
Toxicon. 1992 Aug; 30(8):915-9.T

Abstract

Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that ciguatoxin-1 (MH+ m/z = 1112), ciguatoxin-2 and ciguatoxin-3 are the major ciguatoxins present in the flesh of ciguateric fish. Ciguatoxin-1, -2 and -3 were present in yields of 0.19, 0.09 and 0.02 microgram/kg flesh, respectively, in Scomberomorus commersoni; 0.08, 0.09 and 0.07 microgram/kg flesh, respectively, in Plectropomus spp. and; 0.67, 0.61 and 0.06 microgram/kg flesh, respectively, in Pomadasys maculatus. Two minor toxins, which may be further oxidised analogues of ciguatoxin-1 and ciguatoxin-2, were also identified. The presence of multiple ciguatoxins in fish flesh has important consequences for the detection of ciguateric fish and may be a contributing factor to the observed variability in the symptoms of ciguatera.

Authors+Show Affiliations

Southern Fisheries Centre, QDPI, Australia.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1523683

Citation

Lewis, R J., and M Sellin. "Multiple Ciguatoxins in the Flesh of Fish." Toxicon : Official Journal of the International Society On Toxinology, vol. 30, no. 8, 1992, pp. 915-9.
Lewis RJ, Sellin M. Multiple ciguatoxins in the flesh of fish. Toxicon. 1992;30(8):915-9.
Lewis, R. J., & Sellin, M. (1992). Multiple ciguatoxins in the flesh of fish. Toxicon : Official Journal of the International Society On Toxinology, 30(8), 915-9.
Lewis RJ, Sellin M. Multiple Ciguatoxins in the Flesh of Fish. Toxicon. 1992;30(8):915-9. PubMed PMID: 1523683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple ciguatoxins in the flesh of fish. AU - Lewis,R J, AU - Sellin,M, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 915 EP - 9 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 30 IS - 8 N2 - Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that ciguatoxin-1 (MH+ m/z = 1112), ciguatoxin-2 and ciguatoxin-3 are the major ciguatoxins present in the flesh of ciguateric fish. Ciguatoxin-1, -2 and -3 were present in yields of 0.19, 0.09 and 0.02 microgram/kg flesh, respectively, in Scomberomorus commersoni; 0.08, 0.09 and 0.07 microgram/kg flesh, respectively, in Plectropomus spp. and; 0.67, 0.61 and 0.06 microgram/kg flesh, respectively, in Pomadasys maculatus. Two minor toxins, which may be further oxidised analogues of ciguatoxin-1 and ciguatoxin-2, were also identified. The presence of multiple ciguatoxins in fish flesh has important consequences for the detection of ciguateric fish and may be a contributing factor to the observed variability in the symptoms of ciguatera. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/1523683/Multiple_ciguatoxins_in_the_flesh_of_fish_ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.