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Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists.
Fertil Steril. 2004 Jul; 82(1):102-7.FS

Abstract

OBJECTIVE

To assess the effect of altering the timing of hCG administration on ongoing pregnancy rates in patients stimulated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF.

DESIGN

Prospective, randomized, controlled trial.

SETTING

Tertiary referral center.

PATIENT(S)

Four hundred thirteen patients undergoing IVF.

INTERVENTION(S)

Rec-FSH stimulation starting on day 2 of the cycle combined with daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10000 IU of hCG either as soon as at least three follicles were >or=17 mm on ultrasound (early-hCG group, 208 patients) or 2 days later after this criterion was met (late-hCG group, 205 patients).

MAIN OUTCOME MEASURE(S)

Ongoing pregnancy rate.

RESULT(S)

Fertilization rates and number and quality of embryos transferred did not differ between the two groups. However, a significantly lower ongoing pregnancy rate was present in the late-hCG as compared with the early-hCG group (25.0% vs. 35.6%, respectively).

CONCLUSION(S)

Prolongation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated with a significantly lower ongoing pregnancy rate.

Authors+Show Affiliations

Centre for Reproductive Medicine, Dutch-Speaking Brussels Free University, Brussels, Belgium. stratis@easynet.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15236997

Citation

Kolibianakis, Efstratios M., et al. "Prolongation of the Follicular Phase in in Vitro Fertilization Results in a Lower Ongoing Pregnancy Rate in Cycles Stimulated With Recombinant Follicle-stimulating Hormone and Gonadotropin-releasing Hormone Antagonists." Fertility and Sterility, vol. 82, no. 1, 2004, pp. 102-7.
Kolibianakis EM, Albano C, Camus M, et al. Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertil Steril. 2004;82(1):102-7.
Kolibianakis, E. M., Albano, C., Camus, M., Tournaye, H., Van Steirteghem, A. C., & Devroey, P. (2004). Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertility and Sterility, 82(1), 102-7.
Kolibianakis EM, et al. Prolongation of the Follicular Phase in in Vitro Fertilization Results in a Lower Ongoing Pregnancy Rate in Cycles Stimulated With Recombinant Follicle-stimulating Hormone and Gonadotropin-releasing Hormone Antagonists. Fertil Steril. 2004;82(1):102-7. PubMed PMID: 15236997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. AU - Kolibianakis,Efstratios M, AU - Albano,Carola, AU - Camus,Michel, AU - Tournaye,Herman, AU - Van Steirteghem,André C, AU - Devroey,Paul, PY - 2003/08/22/received PY - 2004/01/30/revised PY - 2004/01/30/accepted PY - 2004/7/9/pubmed PY - 2004/8/18/medline PY - 2004/7/9/entrez SP - 102 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 82 IS - 1 N2 - OBJECTIVE: To assess the effect of altering the timing of hCG administration on ongoing pregnancy rates in patients stimulated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF. DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary referral center. PATIENT(S): Four hundred thirteen patients undergoing IVF. INTERVENTION(S): Rec-FSH stimulation starting on day 2 of the cycle combined with daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10000 IU of hCG either as soon as at least three follicles were >or=17 mm on ultrasound (early-hCG group, 208 patients) or 2 days later after this criterion was met (late-hCG group, 205 patients). MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate. RESULT(S): Fertilization rates and number and quality of embryos transferred did not differ between the two groups. However, a significantly lower ongoing pregnancy rate was present in the late-hCG as compared with the early-hCG group (25.0% vs. 35.6%, respectively). CONCLUSION(S): Prolongation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated with a significantly lower ongoing pregnancy rate. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/15236997/Prolongation_of_the_follicular_phase_in_in_vitro_fertilization_results_in_a_lower_ongoing_pregnancy_rate_in_cycles_stimulated_with_recombinant_follicle_stimulating_hormone_and_gonadotropin_releasing_hormone_antagonists_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028204006041 DB - PRIME DP - Unbound Medicine ER -