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Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists.
Fertil Steril. 2004 Jul; 82(1):167-71.FS

Abstract

OBJECTIVE

To evaluate the endometrium obtained during the luteal phase of controlled ovarian hyperstimulation (COH) cycles utilizing gonadotropin-releasing hormone (GnRH) antagonists, and to compare these findings with those obtained in cycles utilizing a GnRH agonist and with artificial cycles among recipients.

DESIGN

Prospective evaluation of oocyte donors.

SETTING

University-based in vitro fertilization (IVF) center.

PATIENT(S)

Fifteen oocyte donors undergoing standard COH were enrolled in 1 of 3 COH groups, and 40 recipients of oocyte donation were used as a control group.

INTERVENTION(S)

Controlled ovarian hyperstimulation and endometrial biopsy.

MAIN OUTCOME MEASURE(S)

Histological dating of endometrial biopsies, serum estradiol (E(2)) and progesterone levels.

RESULT(S)

On the day of oocyte retrieval, endometrial maturation was advanced by an average of 5.8 +/- 0.4 days in the antagonist group and 5.9 +/- 0.7 days in the agonist group. This advancement persisted on day 7 postoocyte retrieval. Serum progesterone levels were elevated before human chorionic gonadotropin (hCG) administration, but remained similar in both groups.

CONCLUSION(S)

Controlled ovarian hyperstimulation is associated with elevated progesterone levels in the late follicular phase and accelerated endometrial maturation in the subsequent luteal phase. No significant differences exist between preretrieval serial serum progesterone levels and luteal phase endometrial histology between cycles utilizing GnRH agonists or antagonists.

Authors+Show Affiliations

Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California 90033, USA. peymansaadat@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15237007

Citation

Saadat, Peyman, et al. "Accelerated Endometrial Maturation in the Luteal Phase of Cycles Utilizing Controlled Ovarian Hyperstimulation: Impact of Gonadotropin-releasing Hormone Agonists Versus Antagonists." Fertility and Sterility, vol. 82, no. 1, 2004, pp. 167-71.
Saadat P, Boostanfar R, Slater CC, et al. Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists. Fertil Steril. 2004;82(1):167-71.
Saadat, P., Boostanfar, R., Slater, C. C., Tourgeman, D. E., Stanczyk, F. Z., & Paulson, R. J. (2004). Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists. Fertility and Sterility, 82(1), 167-71.
Saadat P, et al. Accelerated Endometrial Maturation in the Luteal Phase of Cycles Utilizing Controlled Ovarian Hyperstimulation: Impact of Gonadotropin-releasing Hormone Agonists Versus Antagonists. Fertil Steril. 2004;82(1):167-71. PubMed PMID: 15237007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists. AU - Saadat,Peyman, AU - Boostanfar,Robert, AU - Slater,Cristin C, AU - Tourgeman,David E, AU - Stanczyk,Frank Z, AU - Paulson,Richard J, PY - 2003/04/07/received PY - 2003/11/25/revised PY - 2003/11/25/accepted PY - 2004/7/9/pubmed PY - 2004/8/18/medline PY - 2004/7/9/entrez SP - 167 EP - 71 JF - Fertility and sterility JO - Fertil. Steril. VL - 82 IS - 1 N2 - OBJECTIVE: To evaluate the endometrium obtained during the luteal phase of controlled ovarian hyperstimulation (COH) cycles utilizing gonadotropin-releasing hormone (GnRH) antagonists, and to compare these findings with those obtained in cycles utilizing a GnRH agonist and with artificial cycles among recipients. DESIGN: Prospective evaluation of oocyte donors. SETTING: University-based in vitro fertilization (IVF) center. PATIENT(S): Fifteen oocyte donors undergoing standard COH were enrolled in 1 of 3 COH groups, and 40 recipients of oocyte donation were used as a control group. INTERVENTION(S): Controlled ovarian hyperstimulation and endometrial biopsy. MAIN OUTCOME MEASURE(S): Histological dating of endometrial biopsies, serum estradiol (E(2)) and progesterone levels. RESULT(S): On the day of oocyte retrieval, endometrial maturation was advanced by an average of 5.8 +/- 0.4 days in the antagonist group and 5.9 +/- 0.7 days in the agonist group. This advancement persisted on day 7 postoocyte retrieval. Serum progesterone levels were elevated before human chorionic gonadotropin (hCG) administration, but remained similar in both groups. CONCLUSION(S): Controlled ovarian hyperstimulation is associated with elevated progesterone levels in the late follicular phase and accelerated endometrial maturation in the subsequent luteal phase. No significant differences exist between preretrieval serial serum progesterone levels and luteal phase endometrial histology between cycles utilizing GnRH agonists or antagonists. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/15237007/Accelerated_endometrial_maturation_in_the_luteal_phase_of_cycles_utilizing_controlled_ovarian_hyperstimulation:_impact_of_gonadotropin_releasing_hormone_agonists_versus_antagonists_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028204005527 DB - PRIME DP - Unbound Medicine ER -