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Minimal erythema dose after multiple UV exposures depends on pre-exposure skin pigmentation.
Photodermatol Photoimmunol Photomed. 2004 Aug; 20(4):163-9.PP

Abstract

BACKGROUND/PURPOSE

Phototherapy consists of multiple ultraviolet (UV) exposures. Most previous studies have focused on erythema following a single UV exposure in fair-skinned persons. Although it is well known that phototherapy lowers the daily UV-threshold dose for erythema in clinical practice, this is insufficiently documented under controlled experimental conditions. The purpose of this study was to quantify the change in the daily threshold for a dose specific erythema grade after 1-4 consecutive daily UV exposures.

METHODS

Forty-nine healthy volunteers (skin type II-V) with varying pigmentation quantified by skin reflectance. Two UV sources were used: a narrowband UVB (Philips TL01) and a Solar Simulator (Solar Light Co.). Just perceptible erythema after 24 h was chosen as the minimal erythema dose (+); besides + and ++ were assessed.

RESULTS

We found a positive and significant exponential relationship between skin pigmentation and UV dose to elicit a specific erythema grade on the back after 1-4 UV exposures. After repetitive UV exposures the UV dose had to be lowered more in dark-skinned persons compared with fair-skinned persons to elicit a certain erythema grade. This applied to both UV sources and all erythema grades.

CONCLUSION

In the dark-skinned persons the daily UV dose after the 4 days UV exposure should be lowered by 40-50% to avoid burns compared with the single UV exposure. For the most fair-skinned persons essentially no reduction in the daily UV dose was needed. Our results indicate that the pre-exposure pigmentation level can guide the UV dosage in phototherapy.

Authors+Show Affiliations

Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. mette.henriksen@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15238093

Citation

Henriksen, M, et al. "Minimal Erythema Dose After Multiple UV Exposures Depends On Pre-exposure Skin Pigmentation." Photodermatology, Photoimmunology & Photomedicine, vol. 20, no. 4, 2004, pp. 163-9.
Henriksen M, Na R, Agren MS, et al. Minimal erythema dose after multiple UV exposures depends on pre-exposure skin pigmentation. Photodermatol Photoimmunol Photomed. 2004;20(4):163-9.
Henriksen, M., Na, R., Agren, M. S., & Wulf, H. C. (2004). Minimal erythema dose after multiple UV exposures depends on pre-exposure skin pigmentation. Photodermatology, Photoimmunology & Photomedicine, 20(4), 163-9.
Henriksen M, et al. Minimal Erythema Dose After Multiple UV Exposures Depends On Pre-exposure Skin Pigmentation. Photodermatol Photoimmunol Photomed. 2004;20(4):163-9. PubMed PMID: 15238093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minimal erythema dose after multiple UV exposures depends on pre-exposure skin pigmentation. AU - Henriksen,M, AU - Na,R, AU - Agren,M S, AU - Wulf,H C, PY - 2004/7/9/pubmed PY - 2004/11/17/medline PY - 2004/7/9/entrez SP - 163 EP - 9 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 20 IS - 4 N2 - BACKGROUND/PURPOSE: Phototherapy consists of multiple ultraviolet (UV) exposures. Most previous studies have focused on erythema following a single UV exposure in fair-skinned persons. Although it is well known that phototherapy lowers the daily UV-threshold dose for erythema in clinical practice, this is insufficiently documented under controlled experimental conditions. The purpose of this study was to quantify the change in the daily threshold for a dose specific erythema grade after 1-4 consecutive daily UV exposures. METHODS: Forty-nine healthy volunteers (skin type II-V) with varying pigmentation quantified by skin reflectance. Two UV sources were used: a narrowband UVB (Philips TL01) and a Solar Simulator (Solar Light Co.). Just perceptible erythema after 24 h was chosen as the minimal erythema dose (+); besides + and ++ were assessed. RESULTS: We found a positive and significant exponential relationship between skin pigmentation and UV dose to elicit a specific erythema grade on the back after 1-4 UV exposures. After repetitive UV exposures the UV dose had to be lowered more in dark-skinned persons compared with fair-skinned persons to elicit a certain erythema grade. This applied to both UV sources and all erythema grades. CONCLUSION: In the dark-skinned persons the daily UV dose after the 4 days UV exposure should be lowered by 40-50% to avoid burns compared with the single UV exposure. For the most fair-skinned persons essentially no reduction in the daily UV dose was needed. Our results indicate that the pre-exposure pigmentation level can guide the UV dosage in phototherapy. SN - 0905-4383 UR - https://www.unboundmedicine.com/medline/citation/15238093/Minimal_erythema_dose_after_multiple_UV_exposures_depends_on_pre_exposure_skin_pigmentation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0905-4383&date=2004&volume=20&issue=4&spage=163 DB - PRIME DP - Unbound Medicine ER -