Tags

Type your tag names separated by a space and hit enter

Paracoccidioidomycosis: an epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests.
Am J Trop Med Hyg. 2004 Jul; 71(1):82-6.AJ

Abstract

Since Paracoccidioides brasiliensis and Histoplasma capsulatum are known to be present in similar environments, there have been many epidemiologic investigations regarding the prevalences of these two organisms. However, cross-reactivity can occur in paracoccidioidin and histoplasmin skin tests, and this usually results in the overestimation of the prevalence of P. brasiliensis. The prevalence of infection with P. brasiliensis was evaluated in a cross-sectional study of 298 asymptomatic school children in the Brazilian Amazon region (Mato Grosso State). In this investigation, the reactivity of children to two different P. brasiliensis antigen preparations, paracoccidioidin and a purified 43-kD glycoprotein (gp43), was compared with or without the co-administration of histoplasmin. In the group of individuals receiving paracoccidioidin who had a positive histoplasmin skin test result, the prevalence of exposure to P. brasiliensis was 44% (16 of 36). This reactivity to P. brasiliensis was significantly higher than that observed in other groups, which ranged from 4% to 6% (P < 5 x 10(-4) for each). Overall prevalence was 4.6% (95% confidence interval = 2.5-7.7%). These data suggest that gp43 provides a better estimate of exposure to P. brasiliensis when the co-administration of histoplasmin is desired.

Authors+Show Affiliations

Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas Carvalho Aguiar, 500 Térreo, Sala 4, CEP 05403-000 São Paulo, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15238694

Citation

Kalmar, E M N., et al. "Paracoccidioidomycosis: an Epidemiologic Survey in a Pediatric Population From the Brazilian Amazon Using Skin Tests." The American Journal of Tropical Medicine and Hygiene, vol. 71, no. 1, 2004, pp. 82-6.
Kalmar EM, Alencar FE, Alves FP, et al. Paracoccidioidomycosis: an epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests. Am J Trop Med Hyg. 2004;71(1):82-6.
Kalmar, E. M., Alencar, F. E., Alves, F. P., Pang, L. W., Del Negro, G. M., Camargo, Z. P., & Shikanai-Yasuda, M. A. (2004). Paracoccidioidomycosis: an epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests. The American Journal of Tropical Medicine and Hygiene, 71(1), 82-6.
Kalmar EM, et al. Paracoccidioidomycosis: an Epidemiologic Survey in a Pediatric Population From the Brazilian Amazon Using Skin Tests. Am J Trop Med Hyg. 2004;71(1):82-6. PubMed PMID: 15238694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paracoccidioidomycosis: an epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests. AU - Kalmar,E M N, AU - Alencar,F E C, AU - Alves,F P, AU - Pang,L W, AU - Del Negro,G M B, AU - Camargo,Z P, AU - Shikanai-Yasuda,M A, PY - 2004/7/9/pubmed PY - 2005/5/3/medline PY - 2004/7/9/entrez SP - 82 EP - 6 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 71 IS - 1 N2 - Since Paracoccidioides brasiliensis and Histoplasma capsulatum are known to be present in similar environments, there have been many epidemiologic investigations regarding the prevalences of these two organisms. However, cross-reactivity can occur in paracoccidioidin and histoplasmin skin tests, and this usually results in the overestimation of the prevalence of P. brasiliensis. The prevalence of infection with P. brasiliensis was evaluated in a cross-sectional study of 298 asymptomatic school children in the Brazilian Amazon region (Mato Grosso State). In this investigation, the reactivity of children to two different P. brasiliensis antigen preparations, paracoccidioidin and a purified 43-kD glycoprotein (gp43), was compared with or without the co-administration of histoplasmin. In the group of individuals receiving paracoccidioidin who had a positive histoplasmin skin test result, the prevalence of exposure to P. brasiliensis was 44% (16 of 36). This reactivity to P. brasiliensis was significantly higher than that observed in other groups, which ranged from 4% to 6% (P < 5 x 10(-4) for each). Overall prevalence was 4.6% (95% confidence interval = 2.5-7.7%). These data suggest that gp43 provides a better estimate of exposure to P. brasiliensis when the co-administration of histoplasmin is desired. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/15238694/Paracoccidioidomycosis:_an_epidemiologic_survey_in_a_pediatric_population_from_the_Brazilian_Amazon_using_skin_tests_ L2 - https://www.diseaseinfosearch.org/result/5576 DB - PRIME DP - Unbound Medicine ER -