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Prevention and treatment of oropharyngeal mucositis following cancer therapy: are there new approaches?
Cancer Nurs 2004 May-Jun; 27(3):183-205CN

Abstract

Oropharyngeal mucositis is an acute and distressing toxic effect of chemotherapy and head and neck irradiation. This oral sequela significantly impairs the daily functioning and quality of life of patients. The biological basis of mucositis is quite complex, involving sequential interaction of chemotherapeutic drugs or irradiation on mitosis of proliferating epithelium, a number of cytokines, and elements of oral microbial environment. Various interventions based on biological attenuation have been tested for mucositis. Such interventions have been reviewed elsewhere; however, most reviews focus on biomedical outcomes. Little attention has been paid to mucositis outcomes with oral morbidity or psychosocial aspects. The purpose of this article is to review the current research studies on the prevention and treatment of oropharyngeal mucositis following chemotherapy, radiotherapy, and bone marrow transplantation with an emphasis on biomedical, oral symptomatic, and functional impairment outcomes. In addition, further avenues of mucositis management, including psychotherapeutic intervention and integrated and stage-based treatment approaches are discussed.

Authors+Show Affiliations

Faculty of Medicine, Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. kariskwong@cuhk.edu.hk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15238805

Citation

Kwong, Karis K F.. "Prevention and Treatment of Oropharyngeal Mucositis Following Cancer Therapy: Are There New Approaches?" Cancer Nursing, vol. 27, no. 3, 2004, pp. 183-205.
Kwong KK. Prevention and treatment of oropharyngeal mucositis following cancer therapy: are there new approaches? Cancer Nurs. 2004;27(3):183-205.
Kwong, K. K. (2004). Prevention and treatment of oropharyngeal mucositis following cancer therapy: are there new approaches? Cancer Nursing, 27(3), pp. 183-205.
Kwong KK. Prevention and Treatment of Oropharyngeal Mucositis Following Cancer Therapy: Are There New Approaches. Cancer Nurs. 2004;27(3):183-205. PubMed PMID: 15238805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention and treatment of oropharyngeal mucositis following cancer therapy: are there new approaches? A1 - Kwong,Karis K F, PY - 2004/7/9/pubmed PY - 2004/11/4/medline PY - 2004/7/9/entrez SP - 183 EP - 205 JF - Cancer nursing JO - Cancer Nurs VL - 27 IS - 3 N2 - Oropharyngeal mucositis is an acute and distressing toxic effect of chemotherapy and head and neck irradiation. This oral sequela significantly impairs the daily functioning and quality of life of patients. The biological basis of mucositis is quite complex, involving sequential interaction of chemotherapeutic drugs or irradiation on mitosis of proliferating epithelium, a number of cytokines, and elements of oral microbial environment. Various interventions based on biological attenuation have been tested for mucositis. Such interventions have been reviewed elsewhere; however, most reviews focus on biomedical outcomes. Little attention has been paid to mucositis outcomes with oral morbidity or psychosocial aspects. The purpose of this article is to review the current research studies on the prevention and treatment of oropharyngeal mucositis following chemotherapy, radiotherapy, and bone marrow transplantation with an emphasis on biomedical, oral symptomatic, and functional impairment outcomes. In addition, further avenues of mucositis management, including psychotherapeutic intervention and integrated and stage-based treatment approaches are discussed. SN - 0162-220X UR - https://www.unboundmedicine.com/medline/citation/15238805/Prevention_and_treatment_of_oropharyngeal_mucositis_following_cancer_therapy:_are_there_new_approaches L2 - http://Insights.ovid.com/pubmed?pmid=15238805 DB - PRIME DP - Unbound Medicine ER -