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Effects of strength, endurance and combined training on myosin heavy chain content and fibre-type distribution in humans.
Eur J Appl Physiol. 2004 Aug; 92(4-5):376-84.EJ

Abstract

This study investigated the effect of strength training, endurance training, and combined strength plus endurance training on fibre-type transitions, fibre cross-sectional area (CSA) and MHC isoform content of the vastus lateralis muscle. Forty volunteers (24 males and 16 females) were randomly assigned to one of four groups: control (C), endurance training (E), strength training (S), or concurrent strength and endurance training (SE). The S and E groups each trained three times a week for 12 weeks; the SE group performed the same S and E training on alternate days. The development of knee extensor muscle strength was S>SE>E (P<0.05) and has been reported elsewhere. The reduction in knee extensor strength development in SE as compared to S corresponded to a 6% increase in MHCIIa content (P<0.05) in SE at the expense of the faster MHCIId(x) isoform (P<0.05), as determined by electrophoretic analyses; reductions in MHCIId/x content after S or E training were attenuated by comparison. Both S and SE induced three- to fourfold reductions (P<0.05) in the proportion of type IIA/IID(X) hybrid fibres. S also induced fourfold increases in the proportion of type I/IIA hybrid fibres within both genders, and in a population of fibres expressing a type I/IID(X) hybrid phenotype within the male subjects. Type I/IIA hybrid fibres were not detected after SE. Both S and SE training paradigms induced similar increases (16-19%, P<0.05) in the CSA of type IIA fibres. In contrast, the increase in CSA of type I fibres was 2.9-fold greater (P<0.05) in S as compared to SE after 12 weeks. We conclude that the interference of knee extensor strength development in SE versus S was related to greater fast-to-slow fibre-type transitions and attenuated hypertrophy of type I fibres. Data are given as mean (SEM) unless otherwise stated.

Authors+Show Affiliations

Exercise Biochemistry Laboratory, Faculty of Physical Education and Recreation, University of Alberta, T6G 2H9, Edmonton, AB, Canada. tputman@ualberta.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15241691

Citation

Putman, Charles T., et al. "Effects of Strength, Endurance and Combined Training On Myosin Heavy Chain Content and Fibre-type Distribution in Humans." European Journal of Applied Physiology, vol. 92, no. 4-5, 2004, pp. 376-84.
Putman CT, Xu X, Gillies E, et al. Effects of strength, endurance and combined training on myosin heavy chain content and fibre-type distribution in humans. Eur J Appl Physiol. 2004;92(4-5):376-84.
Putman, C. T., Xu, X., Gillies, E., MacLean, I. M., & Bell, G. J. (2004). Effects of strength, endurance and combined training on myosin heavy chain content and fibre-type distribution in humans. European Journal of Applied Physiology, 92(4-5), 376-84.
Putman CT, et al. Effects of Strength, Endurance and Combined Training On Myosin Heavy Chain Content and Fibre-type Distribution in Humans. Eur J Appl Physiol. 2004;92(4-5):376-84. PubMed PMID: 15241691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of strength, endurance and combined training on myosin heavy chain content and fibre-type distribution in humans. AU - Putman,Charles T, AU - Xu,Xinhao, AU - Gillies,Ellen, AU - MacLean,Ian M, AU - Bell,Gordon J, Y1 - 2004/07/06/ PY - 2004/03/05/accepted PY - 2004/7/9/pubmed PY - 2004/12/16/medline PY - 2004/7/9/entrez SP - 376 EP - 84 JF - European journal of applied physiology JO - Eur J Appl Physiol VL - 92 IS - 4-5 N2 - This study investigated the effect of strength training, endurance training, and combined strength plus endurance training on fibre-type transitions, fibre cross-sectional area (CSA) and MHC isoform content of the vastus lateralis muscle. Forty volunteers (24 males and 16 females) were randomly assigned to one of four groups: control (C), endurance training (E), strength training (S), or concurrent strength and endurance training (SE). The S and E groups each trained three times a week for 12 weeks; the SE group performed the same S and E training on alternate days. The development of knee extensor muscle strength was S>SE>E (P<0.05) and has been reported elsewhere. The reduction in knee extensor strength development in SE as compared to S corresponded to a 6% increase in MHCIIa content (P<0.05) in SE at the expense of the faster MHCIId(x) isoform (P<0.05), as determined by electrophoretic analyses; reductions in MHCIId/x content after S or E training were attenuated by comparison. Both S and SE induced three- to fourfold reductions (P<0.05) in the proportion of type IIA/IID(X) hybrid fibres. S also induced fourfold increases in the proportion of type I/IIA hybrid fibres within both genders, and in a population of fibres expressing a type I/IID(X) hybrid phenotype within the male subjects. Type I/IIA hybrid fibres were not detected after SE. Both S and SE training paradigms induced similar increases (16-19%, P<0.05) in the CSA of type IIA fibres. In contrast, the increase in CSA of type I fibres was 2.9-fold greater (P<0.05) in S as compared to SE after 12 weeks. We conclude that the interference of knee extensor strength development in SE versus S was related to greater fast-to-slow fibre-type transitions and attenuated hypertrophy of type I fibres. Data are given as mean (SEM) unless otherwise stated. SN - 1439-6319 UR - https://www.unboundmedicine.com/medline/citation/15241691/Effects_of_strength_endurance_and_combined_training_on_myosin_heavy_chain_content_and_fibre_type_distribution_in_humans_ L2 - https://dx.doi.org/10.1007/s00421-004-1104-7 DB - PRIME DP - Unbound Medicine ER -