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Reproductive factors and risk of breast carcinoma in a study of white and African-American women.
Cancer 2004; 101(2):353-62C

Abstract

BACKGROUND

Few studies have investigated the association between reproductive factors and the risk of breast carcinoma among African-American women. The authors assessed whether the number of full-term pregnancies, age at first full-term pregnancy, and total duration of breastfeeding were associated with similar relative risk estimates in white and African-American women in a large multicenter, population-based case-control study of breast carcinoma.

METHODS

Case patients were 4567 women (2950 white women and 1617 African-American women) ages 35-64 years with newly diagnosed invasive breast carcinoma between 1994 and 1998. Control patients were 4668 women (3012 white women and 1656 African-American women) who were identified by random-digit dialing and were frequency matched to case patients according to study center, race, and age. Adjusted odds ratios and 95% confidence intervals were estimated using unconditional logistic regression.

RESULTS

For white women, the reduction in risk of breast carcinoma per full-term pregnancy was 13% among younger women (ages 35-49 years) and 10% among older women (ages 50-64 years). The corresponding risk reductions for African-American women were 10% and 6%, respectively. Risk decreased significantly with increasing number of full-term pregnancies for both races and both age categories. Duration of lactation was inversely associated with breast carcinoma risk among younger parous white (trend P = 0.0001) and African-American (trend P = 0.01) women. African-American women tended to have more children compared with white women, but parity rates were lower in younger women than in older women in both racial groups. However, breastfeeding was substantially more common in young white women than in young African-American women.

CONCLUSIONS

Overall, parity and lactation had similar effects on breast carcinoma risk in white and African-American women. If younger African-American women now are giving birth to fewer children than in the past, without a substantial increase in breastfeeding, breast carcinoma rates may continue to increase at a more rapid rate among these women compared with white women.

Authors+Show Affiliations

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. gursin@usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15241834

Citation

Ursin, Giske, et al. "Reproductive Factors and Risk of Breast Carcinoma in a Study of White and African-American Women." Cancer, vol. 101, no. 2, 2004, pp. 353-62.
Ursin G, Bernstein L, Wang Y, et al. Reproductive factors and risk of breast carcinoma in a study of white and African-American women. Cancer. 2004;101(2):353-62.
Ursin, G., Bernstein, L., Wang, Y., Lord, S. J., Deapen, D., Liff, J. M., ... Spirtas, R. (2004). Reproductive factors and risk of breast carcinoma in a study of white and African-American women. Cancer, 101(2), pp. 353-62.
Ursin G, et al. Reproductive Factors and Risk of Breast Carcinoma in a Study of White and African-American Women. Cancer. 2004 Jul 15;101(2):353-62. PubMed PMID: 15241834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproductive factors and risk of breast carcinoma in a study of white and African-American women. AU - Ursin,Giske, AU - Bernstein,Leslie, AU - Wang,Yaping, AU - Lord,Sarah J, AU - Deapen,Dennis, AU - Liff,Jonathan M, AU - Norman,Sandra A, AU - Weiss,Linda K, AU - Daling,Janet R, AU - Marchbanks,Polly A, AU - Malone,Kathleen E, AU - Folger,Suzanne G, AU - McDonald,Jill A, AU - Burkman,Ronald T, AU - Simon,Michael S, AU - Strom,Brian L, AU - Spirtas,Robert, PY - 2004/7/9/pubmed PY - 2004/7/28/medline PY - 2004/7/9/entrez SP - 353 EP - 62 JF - Cancer JO - Cancer VL - 101 IS - 2 N2 - BACKGROUND: Few studies have investigated the association between reproductive factors and the risk of breast carcinoma among African-American women. The authors assessed whether the number of full-term pregnancies, age at first full-term pregnancy, and total duration of breastfeeding were associated with similar relative risk estimates in white and African-American women in a large multicenter, population-based case-control study of breast carcinoma. METHODS: Case patients were 4567 women (2950 white women and 1617 African-American women) ages 35-64 years with newly diagnosed invasive breast carcinoma between 1994 and 1998. Control patients were 4668 women (3012 white women and 1656 African-American women) who were identified by random-digit dialing and were frequency matched to case patients according to study center, race, and age. Adjusted odds ratios and 95% confidence intervals were estimated using unconditional logistic regression. RESULTS: For white women, the reduction in risk of breast carcinoma per full-term pregnancy was 13% among younger women (ages 35-49 years) and 10% among older women (ages 50-64 years). The corresponding risk reductions for African-American women were 10% and 6%, respectively. Risk decreased significantly with increasing number of full-term pregnancies for both races and both age categories. Duration of lactation was inversely associated with breast carcinoma risk among younger parous white (trend P = 0.0001) and African-American (trend P = 0.01) women. African-American women tended to have more children compared with white women, but parity rates were lower in younger women than in older women in both racial groups. However, breastfeeding was substantially more common in young white women than in young African-American women. CONCLUSIONS: Overall, parity and lactation had similar effects on breast carcinoma risk in white and African-American women. If younger African-American women now are giving birth to fewer children than in the past, without a substantial increase in breastfeeding, breast carcinoma rates may continue to increase at a more rapid rate among these women compared with white women. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15241834/Reproductive_factors_and_risk_of_breast_carcinoma_in_a_study_of_white_and_African_American_women_ L2 - https://doi.org/10.1002/cncr.20373 DB - PRIME DP - Unbound Medicine ER -