Tags

Type your tag names separated by a space and hit enter

Microbial transformations of alpha-santonin.
Z Naturforsch C J Biosci. 2004 Mar-Apr; 59(3-4):209-14.ZN

Abstract

Fungal biotransformations of alpha-santonin (1) were conducted with Mucor plumbeus (ATCC 4740), Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245), Curvularia lunata (ATCC 12017) and Rhizopus stolonifer (ATCC 10404). Rhizopus stolonifer (ATCC 10404) metabolized compound 1 to afford 3,4-epoxy-alpha-santonin (2) and 4,5-dihydro-alpha-santonin (3) while Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245) and Mucor plumbeus (ATCC 4740) were capable of metabolizing compound 1 to give a reported metabolite, 1,2-dihydro-alpha-santonin (4). The structures of these transformed metabolites were established with the aid of extensive spectroscopic studies. These fungi regiospecifically reduced the carbon-carbon double bond in ring A of alpha-santonin.

Authors+Show Affiliations

Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9. a.ata@uwinnipeg.caNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15241928

Citation

Ata, Athar, and Jason A. Nachtigall. "Microbial Transformations of Alpha-santonin." Zeitschrift Fur Naturforschung. C, Journal of Biosciences, vol. 59, no. 3-4, 2004, pp. 209-14.
Ata A, Nachtigall JA. Microbial transformations of alpha-santonin. Z Naturforsch, C, J Biosci. 2004;59(3-4):209-14.
Ata, A., & Nachtigall, J. A. (2004). Microbial transformations of alpha-santonin. Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 59(3-4), 209-14.
Ata A, Nachtigall JA. Microbial Transformations of Alpha-santonin. Z Naturforsch, C, J Biosci. 2004 Mar-Apr;59(3-4):209-14. PubMed PMID: 15241928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial transformations of alpha-santonin. AU - Ata,Athar, AU - Nachtigall,Jason A, PY - 2004/7/10/pubmed PY - 2004/9/17/medline PY - 2004/7/10/entrez SP - 209 EP - 14 JF - Zeitschrift fur Naturforschung. C, Journal of biosciences JO - Z. Naturforsch., C, J. Biosci. VL - 59 IS - 3-4 N2 - Fungal biotransformations of alpha-santonin (1) were conducted with Mucor plumbeus (ATCC 4740), Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245), Curvularia lunata (ATCC 12017) and Rhizopus stolonifer (ATCC 10404). Rhizopus stolonifer (ATCC 10404) metabolized compound 1 to afford 3,4-epoxy-alpha-santonin (2) and 4,5-dihydro-alpha-santonin (3) while Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245) and Mucor plumbeus (ATCC 4740) were capable of metabolizing compound 1 to give a reported metabolite, 1,2-dihydro-alpha-santonin (4). The structures of these transformed metabolites were established with the aid of extensive spectroscopic studies. These fungi regiospecifically reduced the carbon-carbon double bond in ring A of alpha-santonin. SN - 0939-5075 UR - https://www.unboundmedicine.com/medline/citation/15241928/Microbial_transformations_of_alpha_santonin_ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.