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Different clinical and coronary angiographic findings according to ratios of total cholesterol to high-density lipoprotein cholesterol during the acute phase of myocardial infarction.
J Cardiol. 2004 Jun; 43(6):251-8.JC

Abstract

OBJECTIVES

Several pathological studies have shown that a higher ratio of the serum total cholesterol concentration to the high-density lipoprotein cholesterol concentration (TC/HDL-C ratio) is associated with plaque rupture in patients with acute coronary syndromes. We examined the relationship between the serum total cholesterol concentration and the TC/HDL-C ratio, and clinical and angiographic findings in patients with first acute myocardial infarction.

METHODS

Two hundred eighty patients were classified into quartiles according to the TC/HDL-C ratio measured within 24 hr from symptom onset: 70 patients in the first quartile (group L: mean TC/HDL-C ratio, 3.0), 140 in the second and third quartiles (group M: mean TC/HDL-C ratio, 4.6), and 70 in the fourth quartile (group H: mean TC/HDL-C ratio, 7.5).

RESULTS

There were no differences among the three groups with regard to sex, diabetes mellitus or hypertension. Patients in group L were older (66 +/- 9 vs 60 +/- 11, 56 +/- 10 years, p < 0.01) and had a higher incidence of stable angina before acute myocardial infarction (26% vs 14%, 10%, p < 0.05) than in patients groups M and H. Although coronary angiograms revealed no difference in the number of diseased vessels among the three groups, extent index indicating the proportion of each coronary segment that appears angiographically abnormal was lowest in group L (0.7 +/- 0.5), followed by group M (1.3 +/- 0.6), and high- est in group H (1.7 +/- 0.6, p < 0.01). The number of segments with calcification and the incidence of calcification in the culprit lesion were higher in group L than in groups M and H.

CONCLUSIONS

Our findings suggest that the clinical presentations and angiographic appearances differ according to the TC/HDL-C ratio in the acute phase of acute myocardial infarction.

Authors+Show Affiliations

Division of Cardiology, Yokohama City University Medical Center, Urafune-cho 4-57, Minami-ku, Yokohama 232-0024.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15242074

Citation

Kosuge, Masami, et al. "Different Clinical and Coronary Angiographic Findings According to Ratios of Total Cholesterol to High-density Lipoprotein Cholesterol During the Acute Phase of Myocardial Infarction." Journal of Cardiology, vol. 43, no. 6, 2004, pp. 251-8.
Kosuge M, Kimura K, Ishikawa T, et al. Different clinical and coronary angiographic findings according to ratios of total cholesterol to high-density lipoprotein cholesterol during the acute phase of myocardial infarction. J Cardiol. 2004;43(6):251-8.
Kosuge, M., Kimura, K., Ishikawa, T., Shimizu, T., Sugano, T., Sumita, S., Hibi, K., Takamura, T., Toda, N., Kanna, M., Tsukahara, K., Okuda, J., Tahara, Y., Nozawa, N., Furukawa, E., & Umemura, S. (2004). Different clinical and coronary angiographic findings according to ratios of total cholesterol to high-density lipoprotein cholesterol during the acute phase of myocardial infarction. Journal of Cardiology, 43(6), 251-8.
Kosuge M, et al. Different Clinical and Coronary Angiographic Findings According to Ratios of Total Cholesterol to High-density Lipoprotein Cholesterol During the Acute Phase of Myocardial Infarction. J Cardiol. 2004;43(6):251-8. PubMed PMID: 15242074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different clinical and coronary angiographic findings according to ratios of total cholesterol to high-density lipoprotein cholesterol during the acute phase of myocardial infarction. AU - Kosuge,Masami, AU - Kimura,Kazuo, AU - Ishikawa,Toshiyuki, AU - Shimizu,Tomoaki, AU - Sugano,Teruyasu, AU - Sumita,Shinichi, AU - Hibi,Kiyoshi, AU - Takamura,Takeshi, AU - Toda,Noritaka, AU - Kanna,Masahiko, AU - Tsukahara,Kengo, AU - Okuda,Jun, AU - Tahara,Yoshio, AU - Nozawa,Naoki, AU - Furukawa,Eri, AU - Umemura,Satoshi, PY - 2004/7/10/pubmed PY - 2004/8/28/medline PY - 2004/7/10/entrez SP - 251 EP - 8 JF - Journal of cardiology JO - J Cardiol VL - 43 IS - 6 N2 - OBJECTIVES: Several pathological studies have shown that a higher ratio of the serum total cholesterol concentration to the high-density lipoprotein cholesterol concentration (TC/HDL-C ratio) is associated with plaque rupture in patients with acute coronary syndromes. We examined the relationship between the serum total cholesterol concentration and the TC/HDL-C ratio, and clinical and angiographic findings in patients with first acute myocardial infarction. METHODS: Two hundred eighty patients were classified into quartiles according to the TC/HDL-C ratio measured within 24 hr from symptom onset: 70 patients in the first quartile (group L: mean TC/HDL-C ratio, 3.0), 140 in the second and third quartiles (group M: mean TC/HDL-C ratio, 4.6), and 70 in the fourth quartile (group H: mean TC/HDL-C ratio, 7.5). RESULTS: There were no differences among the three groups with regard to sex, diabetes mellitus or hypertension. Patients in group L were older (66 +/- 9 vs 60 +/- 11, 56 +/- 10 years, p < 0.01) and had a higher incidence of stable angina before acute myocardial infarction (26% vs 14%, 10%, p < 0.05) than in patients groups M and H. Although coronary angiograms revealed no difference in the number of diseased vessels among the three groups, extent index indicating the proportion of each coronary segment that appears angiographically abnormal was lowest in group L (0.7 +/- 0.5), followed by group M (1.3 +/- 0.6), and high- est in group H (1.7 +/- 0.6, p < 0.01). The number of segments with calcification and the incidence of calcification in the culprit lesion were higher in group L than in groups M and H. CONCLUSIONS: Our findings suggest that the clinical presentations and angiographic appearances differ according to the TC/HDL-C ratio in the acute phase of acute myocardial infarction. SN - 0914-5087 UR - https://www.unboundmedicine.com/medline/citation/15242074/Different_clinical_and_coronary_angiographic_findings_according_to_ratios_of_total_cholesterol_to_high_density_lipoprotein_cholesterol_during_the_acute_phase_of_myocardial_infarction_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -