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Mortality in Parkinson's disease and its association with dementia and depression.
Acta Neurol Scand. 2004 Aug; 110(2):118-23.AN

Abstract

OBJECTIVE

To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD.

MATERIAL AND METHODS

Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up.

RESULTS

The hazard ratio (HR) for mortality in PD patients compared with controls was 1.64 (95% CI: 1.21-2.23). Multivariate analysis showed age, dementia and depression were independent predictors of mortality but age at onset of PD and severity of neurological symptoms were not. The HR for age was 1.09 (95% CI: 1.05-1.13), for dementia 1.94 (95% CI: 1.26-2.99), and for depression 2.66 (95% CI: 1.59-4.44).

CONCLUSION

Mortality in PD is increased compared with controls. Psychological variables are important predictors of mortality in PD.

Authors+Show Affiliations

Academic Unit of Psychiatry and Behavioural Sciences, University of Leeds, Leeds, UK. tom.hughes@leedsmh.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15242420

Citation

Hughes, T A., et al. "Mortality in Parkinson's Disease and Its Association With Dementia and Depression." Acta Neurologica Scandinavica, vol. 110, no. 2, 2004, pp. 118-23.
Hughes TA, Ross HF, Mindham RH, et al. Mortality in Parkinson's disease and its association with dementia and depression. Acta Neurol Scand. 2004;110(2):118-23.
Hughes, T. A., Ross, H. F., Mindham, R. H., & Spokes, E. G. (2004). Mortality in Parkinson's disease and its association with dementia and depression. Acta Neurologica Scandinavica, 110(2), 118-23.
Hughes TA, et al. Mortality in Parkinson's Disease and Its Association With Dementia and Depression. Acta Neurol Scand. 2004;110(2):118-23. PubMed PMID: 15242420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mortality in Parkinson's disease and its association with dementia and depression. AU - Hughes,T A, AU - Ross,H F, AU - Mindham,R H S, AU - Spokes,E G S, PY - 2004/7/10/pubmed PY - 2004/10/20/medline PY - 2004/7/10/entrez SP - 118 EP - 23 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 110 IS - 2 N2 - OBJECTIVE: To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD. MATERIAL AND METHODS: Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up. RESULTS: The hazard ratio (HR) for mortality in PD patients compared with controls was 1.64 (95% CI: 1.21-2.23). Multivariate analysis showed age, dementia and depression were independent predictors of mortality but age at onset of PD and severity of neurological symptoms were not. The HR for age was 1.09 (95% CI: 1.05-1.13), for dementia 1.94 (95% CI: 1.26-2.99), and for depression 2.66 (95% CI: 1.59-4.44). CONCLUSION: Mortality in PD is increased compared with controls. Psychological variables are important predictors of mortality in PD. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/15242420/Mortality_in_Parkinson's_disease_and_its_association_with_dementia_and_depression_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=2004&volume=110&issue=2&spage=118 DB - PRIME DP - Unbound Medicine ER -