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Autonomic responses to heartburn induced by esophageal acid infusion.
J Gastroenterol Hepatol. 2004 Aug; 19(8):922-6.JG

Abstract

BACKGROUND AND AIM

Studies have shown that altered visceral perception and lower pain thresholds in patients with symptomatic gastroesophageal reflux disease (GERD) and non-cardiac chest pain. Autonomic changes associated with the perception of heartburn in patients with GERD are poorly understood.

METHODS

A total of 12 GERD patients (six male, six female; mean age 37.2 +/- 2.7 years) and 12 controls (five male, seven female; mean age 32.8 +/- 2.2 years) were studied. The study protocol included a 20-min water infusion (6 mL/min), and 20-min acid infusion (0.1 N HCl, 6 mL/min). Spectral analysis of heart-rate variability (HRV) was used to assess autonomic functioning. The measured HRV indices included the power in the low-frequency (LF) band (0.04-0.15 Hz) reflecting sympathetic tone, and power in the high-frequency (HF) band (0.15-0.5 Hz) reflecting vagal tone, and the LF/HF ratio as an indicator of sympathovagal balance.

RESULTS

The GERD group experienced more heartburn than controls with acid infusion. Between-group comparisons showed no significant changes in LF band power in any period. The HF band power was significantly lower in GERD patients during all infusion periods. The LF/HF ratio was significantly larger in GERD patients.

CONCLUSIONS

The perception of heartburn induced by esophageal acid infusion is associated with a simultaneous increase in sympathetic modulation in patients with GERD. The autonomic responses with esophageal acid infusion are significantly different between healthy subjects and GERD patients.

Authors+Show Affiliations

Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, 707, Section 3 Chung-Yang Road, Hualien 970, Taiwan. clchen@tzuchi.org.twNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15242497

Citation

Chen, Chien-Lin, and William C. Orr. "Autonomic Responses to Heartburn Induced By Esophageal Acid Infusion." Journal of Gastroenterology and Hepatology, vol. 19, no. 8, 2004, pp. 922-6.
Chen CL, Orr WC. Autonomic responses to heartburn induced by esophageal acid infusion. J Gastroenterol Hepatol. 2004;19(8):922-6.
Chen, C. L., & Orr, W. C. (2004). Autonomic responses to heartburn induced by esophageal acid infusion. Journal of Gastroenterology and Hepatology, 19(8), 922-6.
Chen CL, Orr WC. Autonomic Responses to Heartburn Induced By Esophageal Acid Infusion. J Gastroenterol Hepatol. 2004;19(8):922-6. PubMed PMID: 15242497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic responses to heartburn induced by esophageal acid infusion. AU - Chen,Chien-Lin, AU - Orr,William C, PY - 2004/7/10/pubmed PY - 2005/3/16/medline PY - 2004/7/10/entrez SP - 922 EP - 6 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 19 IS - 8 N2 - BACKGROUND AND AIM: Studies have shown that altered visceral perception and lower pain thresholds in patients with symptomatic gastroesophageal reflux disease (GERD) and non-cardiac chest pain. Autonomic changes associated with the perception of heartburn in patients with GERD are poorly understood. METHODS: A total of 12 GERD patients (six male, six female; mean age 37.2 +/- 2.7 years) and 12 controls (five male, seven female; mean age 32.8 +/- 2.2 years) were studied. The study protocol included a 20-min water infusion (6 mL/min), and 20-min acid infusion (0.1 N HCl, 6 mL/min). Spectral analysis of heart-rate variability (HRV) was used to assess autonomic functioning. The measured HRV indices included the power in the low-frequency (LF) band (0.04-0.15 Hz) reflecting sympathetic tone, and power in the high-frequency (HF) band (0.15-0.5 Hz) reflecting vagal tone, and the LF/HF ratio as an indicator of sympathovagal balance. RESULTS: The GERD group experienced more heartburn than controls with acid infusion. Between-group comparisons showed no significant changes in LF band power in any period. The HF band power was significantly lower in GERD patients during all infusion periods. The LF/HF ratio was significantly larger in GERD patients. CONCLUSIONS: The perception of heartburn induced by esophageal acid infusion is associated with a simultaneous increase in sympathetic modulation in patients with GERD. The autonomic responses with esophageal acid infusion are significantly different between healthy subjects and GERD patients. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/15242497/Autonomic_responses_to_heartburn_induced_by_esophageal_acid_infusion_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2004&volume=19&issue=8&spage=922 DB - PRIME DP - Unbound Medicine ER -