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Drug desensitization.
Immunol Allergy Clin North Am 2004; 24(3):425-43, viIA

Abstract

Although most patients who report a history of drug allergy are not truly allergic, this article focuses on those individuals with confirmed drug hypersensitivity. Desensitization is an immunologic method that allows allergic patients to receive the sensitizing drug safely. Classically, the procedure is applied in IgE-mediated reactions, but its use has been extended to other drug reactions. The most common clinical scenarios wherein desensitization may be needed are reviewed. The discussion includes rapid desensitization of patients with IgE-mediated allergies to penicillin and other classes of antibiotics, and sulfonamide desensitization of HIV-positive patients.

Authors+Show Affiliations

Division of Allergy & Immunology, The Corvallis Clinic, 3680 NW Samaritan Drive, Corvallis, OR 97330, USA. roland.solensky@corvallis-clinic.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15242719

Citation

Solensky, Roland. "Drug Desensitization." Immunology and Allergy Clinics of North America, vol. 24, no. 3, 2004, pp. 425-43, vi.
Solensky R. Drug desensitization. Immunol Allergy Clin North Am. 2004;24(3):425-43, vi.
Solensky, R. (2004). Drug desensitization. Immunology and Allergy Clinics of North America, 24(3), pp. 425-43, vi.
Solensky R. Drug Desensitization. Immunol Allergy Clin North Am. 2004;24(3):425-43, vi. PubMed PMID: 15242719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug desensitization. A1 - Solensky,Roland, PY - 2004/7/10/pubmed PY - 2004/9/15/medline PY - 2004/7/10/entrez SP - 425-43, vi JF - Immunology and allergy clinics of North America JO - Immunol Allergy Clin North Am VL - 24 IS - 3 N2 - Although most patients who report a history of drug allergy are not truly allergic, this article focuses on those individuals with confirmed drug hypersensitivity. Desensitization is an immunologic method that allows allergic patients to receive the sensitizing drug safely. Classically, the procedure is applied in IgE-mediated reactions, but its use has been extended to other drug reactions. The most common clinical scenarios wherein desensitization may be needed are reviewed. The discussion includes rapid desensitization of patients with IgE-mediated allergies to penicillin and other classes of antibiotics, and sulfonamide desensitization of HIV-positive patients. SN - 0889-8561 UR - https://www.unboundmedicine.com/medline/citation/15242719/Drug_desensitization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889856104000347 DB - PRIME DP - Unbound Medicine ER -