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Sulfonamide hypersensitivity.
Immunol Allergy Clin North Am 2004; 24(3):477-90, viiIA

Abstract

Sulfonamide antibiotics can result in a wide variety of hypersensitivity reactions. No validated diagnostic tests are available for sulfonamide reactions; therefore, clinicians must rely on the combination of a careful patient history, review of medical records, and a sound knowledge base regarding the common clinical manifestations of sulfonamide hypersensitivity reactions. Although HIV-infected individuals have a high risk for hypersensitivity reactions to sulfamethoxazole, readministering the drug can usually be performed safely by using a desensitization protocol. Sulfonamide-containing medications that are not antibiotics also have the capacity for causing hypersensitivity reactions. Whether the sulfa moiety confers a risk of cross-reaction is controversial. The preponderance of available evidence suggests that sulfonamide antibiotics probably do not cross-react with sulfonamide nonantibiotics.

Authors+Show Affiliations

Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15242722

Citation

Slatore, Christopher G., and Stephen A. Tilles. "Sulfonamide Hypersensitivity." Immunology and Allergy Clinics of North America, vol. 24, no. 3, 2004, pp. 477-90, vii.
Slatore CG, Tilles SA. Sulfonamide hypersensitivity. Immunol Allergy Clin North Am. 2004;24(3):477-90, vii.
Slatore, C. G., & Tilles, S. A. (2004). Sulfonamide hypersensitivity. Immunology and Allergy Clinics of North America, 24(3), pp. 477-90, vii.
Slatore CG, Tilles SA. Sulfonamide Hypersensitivity. Immunol Allergy Clin North Am. 2004;24(3):477-90, vii. PubMed PMID: 15242722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfonamide hypersensitivity. AU - Slatore,Christopher G, AU - Tilles,Stephen A, PY - 2004/7/10/pubmed PY - 2004/9/15/medline PY - 2004/7/10/entrez SP - 477-90, vii JF - Immunology and allergy clinics of North America JO - Immunol Allergy Clin North Am VL - 24 IS - 3 N2 - Sulfonamide antibiotics can result in a wide variety of hypersensitivity reactions. No validated diagnostic tests are available for sulfonamide reactions; therefore, clinicians must rely on the combination of a careful patient history, review of medical records, and a sound knowledge base regarding the common clinical manifestations of sulfonamide hypersensitivity reactions. Although HIV-infected individuals have a high risk for hypersensitivity reactions to sulfamethoxazole, readministering the drug can usually be performed safely by using a desensitization protocol. Sulfonamide-containing medications that are not antibiotics also have the capacity for causing hypersensitivity reactions. Whether the sulfa moiety confers a risk of cross-reaction is controversial. The preponderance of available evidence suggests that sulfonamide antibiotics probably do not cross-react with sulfonamide nonantibiotics. SN - 0889-8561 UR - https://www.unboundmedicine.com/medline/citation/15242722/Sulfonamide_hypersensitivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889856104000542 DB - PRIME DP - Unbound Medicine ER -