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Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study.
Stroke 2004; 35(9):2150-4S

Abstract

BACKGROUND AND PURPOSE

Carotid intima-media thickness (IMT) progression rates are increasingly used as an intermediate outcome for vascular risk. The carotid bifurcation (BIF) and internal carotid artery (ICA) are predilection sites for atherosclerosis. IMT measures from these sites may be a better estimate of atherosclerosis than common carotid artery (CCA) IMT. The study aim was to evaluate site-specific IMT progression rates and their relationships to vascular risk factors compared with baseline IMT measurements.

METHODS

In a community population (n=3383), ICA-IMT, BIF-IMT, CCA-IMT, and vascular risk factors were evaluated at baseline and at 3-year follow-up.

RESULTS

Mean (SD) IMT progression was significantly greater at the ICA (0.032 [0.109] mm/year) compared with the BIF (0.023 [0.108] mm/year) and the CCA (0.001 [0.040] mm/year) (P<0.001). Only ICA-IMT progression significantly correlated with baseline vascular risk factors (age, male gender, hypertension, diabetes, and smoking). Change in risk factor profile over follow-up, estimated using the Framingham risk score, was a predictor of IMT progression only. For all arterial sites, correlations were stronger, by a factor of 2 to 3, for associations with baseline IMT compared with IMT progression.

CONCLUSIONS

Progression rates at the ICA rather than the CCA yield greater absolute changes in IMT and better correlations with vascular risk factors. Vascular risk factors correlate more strongly with baseline IMT than with IMT progression. Prospective data on IMT progression and incident vascular events are required to establish the true value of progression data as a surrogate measure of vascular risk.

Authors+Show Affiliations

Department of Clinical Neurosciences, St. George's Hospital Medical School, Cranmer Terrace, Tooting, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15243147

Citation

Mackinnon, Andrew D., et al. "Rates and Determinants of Site-specific Progression of Carotid Artery Intima-media Thickness: the Carotid Atherosclerosis Progression Study." Stroke, vol. 35, no. 9, 2004, pp. 2150-4.
Mackinnon AD, Jerrard-Dunne P, Sitzer M, et al. Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study. Stroke. 2004;35(9):2150-4.
Mackinnon, A. D., Jerrard-Dunne, P., Sitzer, M., Buehler, A., von Kegler, S., & Markus, H. S. (2004). Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study. Stroke, 35(9), pp. 2150-4.
Mackinnon AD, et al. Rates and Determinants of Site-specific Progression of Carotid Artery Intima-media Thickness: the Carotid Atherosclerosis Progression Study. Stroke. 2004;35(9):2150-4. PubMed PMID: 15243147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study. AU - Mackinnon,Andrew D, AU - Jerrard-Dunne,Paula, AU - Sitzer,Matthias, AU - Buehler,Alexandra, AU - von Kegler,Stefan, AU - Markus,Hugh S, Y1 - 2004/07/08/ PY - 2004/7/10/pubmed PY - 2005/4/6/medline PY - 2004/7/10/entrez SP - 2150 EP - 4 JF - Stroke JO - Stroke VL - 35 IS - 9 N2 - BACKGROUND AND PURPOSE: Carotid intima-media thickness (IMT) progression rates are increasingly used as an intermediate outcome for vascular risk. The carotid bifurcation (BIF) and internal carotid artery (ICA) are predilection sites for atherosclerosis. IMT measures from these sites may be a better estimate of atherosclerosis than common carotid artery (CCA) IMT. The study aim was to evaluate site-specific IMT progression rates and their relationships to vascular risk factors compared with baseline IMT measurements. METHODS: In a community population (n=3383), ICA-IMT, BIF-IMT, CCA-IMT, and vascular risk factors were evaluated at baseline and at 3-year follow-up. RESULTS: Mean (SD) IMT progression was significantly greater at the ICA (0.032 [0.109] mm/year) compared with the BIF (0.023 [0.108] mm/year) and the CCA (0.001 [0.040] mm/year) (P<0.001). Only ICA-IMT progression significantly correlated with baseline vascular risk factors (age, male gender, hypertension, diabetes, and smoking). Change in risk factor profile over follow-up, estimated using the Framingham risk score, was a predictor of IMT progression only. For all arterial sites, correlations were stronger, by a factor of 2 to 3, for associations with baseline IMT compared with IMT progression. CONCLUSIONS: Progression rates at the ICA rather than the CCA yield greater absolute changes in IMT and better correlations with vascular risk factors. Vascular risk factors correlate more strongly with baseline IMT than with IMT progression. Prospective data on IMT progression and incident vascular events are required to establish the true value of progression data as a surrogate measure of vascular risk. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/15243147/Rates_and_determinants_of_site_specific_progression_of_carotid_artery_intima_media_thickness:_the_carotid_atherosclerosis_progression_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000136720.21095.f3?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -