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[Ziprasidone-augmentation of clozapine].
Psychiatr Prax. 2004 Jul; 31(5):259-61.PP

Abstract

OBJECTIVES

In cases of treatment-resistant schizophrenic psychoses combined application of atypical antipsychotic drugs is an often-used strategy.

METHOD

We report the case of a 35-year old man with paranoid schizophrenia, whose symptoms turned out to be resistant to the application of olanzapine, risperidone and quetiapine. After switch to clozapine paranoid delusions remitted, but schizophrenic negative symptoms persisted and side effects limited the patient's compliance. Augmentation with ziprasidone allowed a reduction of the clozapine dose and ameliorated the affective deficits.

RESULTS

Positive and negative symptoms were well controlled. In spite of a transient hyperprolactinaemia and sexual dysfunction the patient was highly content.

DISCUSSION

The combined application of ziprasidone and clozapine follows a neurobiological rationale, seems able to reduce side effects, and should be further evaluated with respect to risk and benefit in prospective studies.

Authors+Show Affiliations

Zink M
Zentralinstitut für Seelische Gesundheit, Klinik für Psychiatrie und Psychotherapie, Mannheim. zink@kv.zi-mannheim.de
Mase E
No affiliation info available
Dressing H
No affiliation info available

MeSH

AdultAntipsychotic AgentsClozapineDose-Response Relationship, DrugDrug InteractionsDrug ResistanceDrug Therapy, CombinationFollicle Stimulating HormoneHumansHyperprolactinemiaMalePiperazinesProlactinPsychiatric Status Rating ScalesSchizophrenia, ParanoidThiazoles

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

15243877

Citation

Zink, Mathias, et al. "[Ziprasidone-augmentation of Clozapine]." Psychiatrische Praxis, vol. 31, no. 5, 2004, pp. 259-61.
Zink M, Mase E, Dressing H. [Ziprasidone-augmentation of clozapine]. Psychiatr Prax. 2004;31(5):259-61.
Zink, M., Mase, E., & Dressing, H. (2004). [Ziprasidone-augmentation of clozapine]. Psychiatrische Praxis, 31(5), 259-61.
Zink M, Mase E, Dressing H. [Ziprasidone-augmentation of Clozapine]. Psychiatr Prax. 2004;31(5):259-61. PubMed PMID: 15243877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Ziprasidone-augmentation of clozapine]. AU - Zink,Mathias, AU - Mase,Evelyn, AU - Dressing,Harald, PY - 2004/7/10/pubmed PY - 2004/10/1/medline PY - 2004/7/10/entrez SP - 259 EP - 61 JF - Psychiatrische Praxis JO - Psychiatr Prax VL - 31 IS - 5 N2 - OBJECTIVES: In cases of treatment-resistant schizophrenic psychoses combined application of atypical antipsychotic drugs is an often-used strategy. METHOD: We report the case of a 35-year old man with paranoid schizophrenia, whose symptoms turned out to be resistant to the application of olanzapine, risperidone and quetiapine. After switch to clozapine paranoid delusions remitted, but schizophrenic negative symptoms persisted and side effects limited the patient's compliance. Augmentation with ziprasidone allowed a reduction of the clozapine dose and ameliorated the affective deficits. RESULTS: Positive and negative symptoms were well controlled. In spite of a transient hyperprolactinaemia and sexual dysfunction the patient was highly content. DISCUSSION: The combined application of ziprasidone and clozapine follows a neurobiological rationale, seems able to reduce side effects, and should be further evaluated with respect to risk and benefit in prospective studies. SN - 0303-4259 UR - https://www.unboundmedicine.com/medline/citation/15243877/[Ziprasidone_augmentation_of_clozapine]_ DB - PRIME DP - Unbound Medicine ER -