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Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion.
J Infect Dis. 2004 Aug 01; 190(3):504-10.JI

Abstract

BACKGROUND

High human T lymphotropic virus (HTLV)-I provirus load (VL) has been associated with an increased risk of HTLV-associated myelopathy, but little is known about variation in HTLV-I or -II VLs by demographic characteristics and risk behaviors.

METHODS

We measured HTLV-I and HTLV-II VLs in a large cohort of 127 HTLV-I-seropositive and 328 HTLV-II-seropositive former blood donors, by use of real-time polymerase chain reaction using tax primers. Multivariable linear regression was used to control for confounding by relevant covariates.

RESULTS

The mean VLs were 3.28 log(10) copies/10(6) peripheral blood mononuclear cells (PBMCs) (range, 0.5-5.3 log(10) copies/10(6) PBMCs) for HTLV-I and 2.60 log(10) copies/10(6) PBMCs (range, 0.05-5.95 log(10) copies/10(6) PBMCs) for HTLV-II (P<.0001). HTLV-II VLs were higher in those subjects with subtype A infection (mean, 2.82 log(10) copies/10(6) PBMCs) than in those with subtype B infection (mean, 2.29 log(10) copies/10(6) PBMCs) (P=.005). Higher HTLV-I VL was associated with previous receipt of a blood transfusion (P=.04), and lower HTLV-II VL was associated with female sex (P=.007). These associations persisted in virus-specific multivariate linear regression models controlling for potential confounding variables.

CONCLUSIONS

VL was significantly higher in HTLV-I than in HTLV-II infection and was higher in HTLV-II subtype A than in HTLV-II subtype B infection. Chronic HTLV VLs may be related to the infectious dose acquired at the time of infection, with higher VLs following acquisition by blood transfusion and lower VLs following sexual acquisition.

Authors+Show Affiliations

Department of Laboratory Medicine, University of California, San Francisco 94118, USA. murphy@itsa.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15243924

Citation

Murphy, Edward L., et al. "Higher Human T Lymphotropic Virus (HTLV) Provirus Load Is Associated With HTLV-I Versus HTLV-II, With HTLV-II Subtype a Versus B, and With Male Sex and a History of Blood Transfusion." The Journal of Infectious Diseases, vol. 190, no. 3, 2004, pp. 504-10.
Murphy EL, Lee TH, Chafets D, et al. Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion. J Infect Dis. 2004;190(3):504-10.
Murphy, E. L., Lee, T. H., Chafets, D., Nass, C. C., Wang, B., Loughlin, K., & Smith, D. (2004). Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion. The Journal of Infectious Diseases, 190(3), 504-10.
Murphy EL, et al. Higher Human T Lymphotropic Virus (HTLV) Provirus Load Is Associated With HTLV-I Versus HTLV-II, With HTLV-II Subtype a Versus B, and With Male Sex and a History of Blood Transfusion. J Infect Dis. 2004 Aug 1;190(3):504-10. PubMed PMID: 15243924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion. AU - Murphy,Edward L, AU - Lee,Tzong-Hae, AU - Chafets,Daniel, AU - Nass,Catharie C, AU - Wang,Baoguang, AU - Loughlin,Katharine, AU - Smith,Donna, AU - ,, Y1 - 2004/07/06/ PY - 2003/12/24/received PY - 2004/02/18/accepted PY - 2004/7/10/pubmed PY - 2004/8/25/medline PY - 2004/7/10/entrez SP - 504 EP - 10 JF - The Journal of infectious diseases JO - J Infect Dis VL - 190 IS - 3 N2 - BACKGROUND: High human T lymphotropic virus (HTLV)-I provirus load (VL) has been associated with an increased risk of HTLV-associated myelopathy, but little is known about variation in HTLV-I or -II VLs by demographic characteristics and risk behaviors. METHODS: We measured HTLV-I and HTLV-II VLs in a large cohort of 127 HTLV-I-seropositive and 328 HTLV-II-seropositive former blood donors, by use of real-time polymerase chain reaction using tax primers. Multivariable linear regression was used to control for confounding by relevant covariates. RESULTS: The mean VLs were 3.28 log(10) copies/10(6) peripheral blood mononuclear cells (PBMCs) (range, 0.5-5.3 log(10) copies/10(6) PBMCs) for HTLV-I and 2.60 log(10) copies/10(6) PBMCs (range, 0.05-5.95 log(10) copies/10(6) PBMCs) for HTLV-II (P<.0001). HTLV-II VLs were higher in those subjects with subtype A infection (mean, 2.82 log(10) copies/10(6) PBMCs) than in those with subtype B infection (mean, 2.29 log(10) copies/10(6) PBMCs) (P=.005). Higher HTLV-I VL was associated with previous receipt of a blood transfusion (P=.04), and lower HTLV-II VL was associated with female sex (P=.007). These associations persisted in virus-specific multivariate linear regression models controlling for potential confounding variables. CONCLUSIONS: VL was significantly higher in HTLV-I than in HTLV-II infection and was higher in HTLV-II subtype A than in HTLV-II subtype B infection. Chronic HTLV VLs may be related to the infectious dose acquired at the time of infection, with higher VLs following acquisition by blood transfusion and lower VLs following sexual acquisition. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/15243924/Higher_human_T_lymphotropic_virus__HTLV__provirus_load_is_associated_with_HTLV_I_versus_HTLV_II_with_HTLV_II_subtype_A_versus_B_and_with_male_sex_and_a_history_of_blood_transfusion_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/422398 DB - PRIME DP - Unbound Medicine ER -