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Obesity, adipocytokines, and insulin resistance in breast cancer.
Obes Rev 2004; 5(3):153-65OR

Abstract

The adipocytokines are biologically active polypeptides that are produced either exclusively or substantially by the adipocytes, and act by endocrine, paracrine, and autocrine mechanisms. Most have been associated with obesity, hyperinsulinaemia, type 2 diabetes, and chronic vascular disease; in addition, six adipocytokines--vascular endothelial growth factor, hepatocyte growth factor, leptin, tumour necrosis factor-alpha, heparin-binding epidermal growth factor-like growth factor, and interleukin-6--promote angiogenesis while one, adiponectin, is inhibitory. Obesity and insulin resistance have both been identified as risk factors for breast cancer and are associated with late-stage disease and poor prognosis. Angiogenesis is essential for breast cancer development and progression, and so it is plausible that obesity-related increases in adipocytokine production and a reduction in adiponectin may adversely affect breast cancer outcome by their angiogenesis-related activities. There is also experimental evidence that some adipocytokines can act directly on breast cancer cells to stimulate their proliferation and invasive capacity. Thus, adipocytokines may provide a biological mechanism by which obesity and insulin resistance are causally associated with breast cancer risk and poor prognosis. Both experimental and clinical studies are needed to develop this concept, and particularly in oestrogen-independent breast cancers where preventive and therapeutic options are limited.

Authors+Show Affiliations

Institute for Cancer Prevention, One Dana Road, Valhalla, NY 10595, USA. davidrosemd@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15245384

Citation

Rose, D P., et al. "Obesity, Adipocytokines, and Insulin Resistance in Breast Cancer." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 5, no. 3, 2004, pp. 153-65.
Rose DP, Komninou D, Stephenson GD. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev. 2004;5(3):153-65.
Rose, D. P., Komninou, D., & Stephenson, G. D. (2004). Obesity, adipocytokines, and insulin resistance in breast cancer. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 5(3), pp. 153-65.
Rose DP, Komninou D, Stephenson GD. Obesity, Adipocytokines, and Insulin Resistance in Breast Cancer. Obes Rev. 2004;5(3):153-65. PubMed PMID: 15245384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, adipocytokines, and insulin resistance in breast cancer. AU - Rose,D P, AU - Komninou,D, AU - Stephenson,G D, PY - 2004/7/13/pubmed PY - 2004/10/27/medline PY - 2004/7/13/entrez SP - 153 EP - 65 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 5 IS - 3 N2 - The adipocytokines are biologically active polypeptides that are produced either exclusively or substantially by the adipocytes, and act by endocrine, paracrine, and autocrine mechanisms. Most have been associated with obesity, hyperinsulinaemia, type 2 diabetes, and chronic vascular disease; in addition, six adipocytokines--vascular endothelial growth factor, hepatocyte growth factor, leptin, tumour necrosis factor-alpha, heparin-binding epidermal growth factor-like growth factor, and interleukin-6--promote angiogenesis while one, adiponectin, is inhibitory. Obesity and insulin resistance have both been identified as risk factors for breast cancer and are associated with late-stage disease and poor prognosis. Angiogenesis is essential for breast cancer development and progression, and so it is plausible that obesity-related increases in adipocytokine production and a reduction in adiponectin may adversely affect breast cancer outcome by their angiogenesis-related activities. There is also experimental evidence that some adipocytokines can act directly on breast cancer cells to stimulate their proliferation and invasive capacity. Thus, adipocytokines may provide a biological mechanism by which obesity and insulin resistance are causally associated with breast cancer risk and poor prognosis. Both experimental and clinical studies are needed to develop this concept, and particularly in oestrogen-independent breast cancers where preventive and therapeutic options are limited. SN - 1467-7881 UR - https://www.unboundmedicine.com/medline/citation/15245384/Obesity_adipocytokines_and_insulin_resistance_in_breast_cancer_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1467-7881&date=2004&volume=5&issue=3&spage=153 DB - PRIME DP - Unbound Medicine ER -