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Mycobacterium leprae-induced demyelination: a model for early nerve degeneration.
Curr Opin Immunol. 2004 Aug; 16(4):511-8.CO

Abstract

The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

Authors+Show Affiliations

The Rockefeller University, Bronk building, Room 501, 1230 York Avenue, New York, New York 10021, USA. rambuka@imap.rockefeller.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15245748

Citation

Rambukkana, Anura. "Mycobacterium Leprae-induced Demyelination: a Model for Early Nerve Degeneration." Current Opinion in Immunology, vol. 16, no. 4, 2004, pp. 511-8.
Rambukkana A. Mycobacterium leprae-induced demyelination: a model for early nerve degeneration. Curr Opin Immunol. 2004;16(4):511-8.
Rambukkana, A. (2004). Mycobacterium leprae-induced demyelination: a model for early nerve degeneration. Current Opinion in Immunology, 16(4), 511-8.
Rambukkana A. Mycobacterium Leprae-induced Demyelination: a Model for Early Nerve Degeneration. Curr Opin Immunol. 2004;16(4):511-8. PubMed PMID: 15245748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycobacterium leprae-induced demyelination: a model for early nerve degeneration. A1 - Rambukkana,Anura, PY - 2004/7/13/pubmed PY - 2005/3/23/medline PY - 2004/7/13/entrez SP - 511 EP - 8 JF - Current opinion in immunology JO - Curr Opin Immunol VL - 16 IS - 4 N2 - The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration. SN - 0952-7915 UR - https://www.unboundmedicine.com/medline/citation/15245748/Mycobacterium_leprae_induced_demyelination:_a_model_for_early_nerve_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952791504000901 DB - PRIME DP - Unbound Medicine ER -