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Normal protein diet for episodic hepatic encephalopathy: results of a randomized study.
J Hepatol 2004; 41(1):38-43JH

Abstract

BACKGROUND/AIMS

Protein-restricted diets are usually prescribed for cirrhotic patients with hepatic encephalopathy. However, protein restriction may worsen the nutritional status without resulting in an improvement of hepatic encephalopathy. We designed a study to assess the effects of the amount of protein in the diet on the evolution of episodic hepatic encephalopathy.

METHODS

Cirrhotics admitted to the hospital because of an episode of encephalopathy (n=30) were randomized to receive a low-protein diet with progressive increments or a normal protein diet for 14 days, in addition to standard measures to treat hepatic encephalopathy. Protein synthesis and breakdown were studied at day 2 and day 14 with the glycine-N(15) infusion method.

RESULTS

The outcome of hepatic encephalopathy was not significantly different between both groups of treatment. Protein synthesis was similar for low and normal protein diet, but those of the low-protein diet group showed higher protein breakdown.

CONCLUSIONS

Diets with a normal content of protein, which are metabolically more adequate, can be administered safely to cirrhotic patients with episodic hepatic encephalopathy. Restriction of the content of protein of the diet does not appear to have any beneficial effect for cirrhotic patients during an episode of encephalopathy.

Authors+Show Affiliations

Servei de Medicina Interna-Hepatologia, Hospital Universitari Vall d'Hebron, Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain. jcordoba@vhebron.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15246205

Citation

Córdoba, Juan, et al. "Normal Protein Diet for Episodic Hepatic Encephalopathy: Results of a Randomized Study." Journal of Hepatology, vol. 41, no. 1, 2004, pp. 38-43.
Córdoba J, López-Hellín J, Planas M, et al. Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. J Hepatol. 2004;41(1):38-43.
Córdoba, J., López-Hellín, J., Planas, M., Sabín, P., Sanpedro, F., Castro, F., ... Guardia, J. (2004). Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. Journal of Hepatology, 41(1), pp. 38-43.
Córdoba J, et al. Normal Protein Diet for Episodic Hepatic Encephalopathy: Results of a Randomized Study. J Hepatol. 2004;41(1):38-43. PubMed PMID: 15246205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. AU - Córdoba,Juan, AU - López-Hellín,Juan, AU - Planas,Mercé, AU - Sabín,Pilar, AU - Sanpedro,Francesc, AU - Castro,Francisco, AU - Esteban,Rafael, AU - Guardia,Jaume, PY - 2003/10/29/received PY - 2004/02/17/revised PY - 2004/03/05/accepted PY - 2004/7/13/pubmed PY - 2005/2/3/medline PY - 2004/7/13/entrez SP - 38 EP - 43 JF - Journal of hepatology JO - J. Hepatol. VL - 41 IS - 1 N2 - BACKGROUND/AIMS: Protein-restricted diets are usually prescribed for cirrhotic patients with hepatic encephalopathy. However, protein restriction may worsen the nutritional status without resulting in an improvement of hepatic encephalopathy. We designed a study to assess the effects of the amount of protein in the diet on the evolution of episodic hepatic encephalopathy. METHODS: Cirrhotics admitted to the hospital because of an episode of encephalopathy (n=30) were randomized to receive a low-protein diet with progressive increments or a normal protein diet for 14 days, in addition to standard measures to treat hepatic encephalopathy. Protein synthesis and breakdown were studied at day 2 and day 14 with the glycine-N(15) infusion method. RESULTS: The outcome of hepatic encephalopathy was not significantly different between both groups of treatment. Protein synthesis was similar for low and normal protein diet, but those of the low-protein diet group showed higher protein breakdown. CONCLUSIONS: Diets with a normal content of protein, which are metabolically more adequate, can be administered safely to cirrhotic patients with episodic hepatic encephalopathy. Restriction of the content of protein of the diet does not appear to have any beneficial effect for cirrhotic patients during an episode of encephalopathy. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/15246205/Normal_protein_diet_for_episodic_hepatic_encephalopathy:_results_of_a_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168827804001606 DB - PRIME DP - Unbound Medicine ER -