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Sporadic cases of acute autochthonous hepatitis E in Spain.
J Hepatol. 2004 Jul; 41(1):126-31.JH

Abstract

BACKGROUND/AIMS

In industrialized countries hepatitis E virus (HEV) infection is rare and its diagnosis is difficult because the utility of available tests is not well established.

METHODS

We studied the presence of acute HEV infection markers in a cluster of 11 cases of acute hepatitis with IgG anti-HEV antibodies.

RESULTS

Three cases were confirmed as acute hepatitis E and 8 as presumptive hepatitis E, two as a past HEV infection and one could not be determined. Three different HEV strains were identified in serum from 3 patients. Two strains belonged to genotype 3, the predominant genotype found in local urban sewage and the other strain belonged to genotype 1 and was considered an imported strain.

CONCLUSIONS

Our findings demonstrate the presence of some autochthonous, sporadic acute hepatitis E cases as well as an imported case in our area and the transitory nature of virological and serological markers for HEV.

Authors+Show Affiliations

Liver Unit, Hospital General Universitario Valle Hebron, Paseo Valle de Hebron 119, 08035 Barcelona, Spain. mbuti@vhebron.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15246218

Citation

Buti, Maria, et al. "Sporadic Cases of Acute Autochthonous Hepatitis E in Spain." Journal of Hepatology, vol. 41, no. 1, 2004, pp. 126-31.
Buti M, Clemente-Casares P, Jardi R, et al. Sporadic cases of acute autochthonous hepatitis E in Spain. J Hepatol. 2004;41(1):126-31.
Buti, M., Clemente-Casares, P., Jardi, R., Formiga-Cruz, M., Schaper, M., Valdes, A., Rodriguez-Frias, F., Esteban, R., & Girones, R. (2004). Sporadic cases of acute autochthonous hepatitis E in Spain. Journal of Hepatology, 41(1), 126-31.
Buti M, et al. Sporadic Cases of Acute Autochthonous Hepatitis E in Spain. J Hepatol. 2004;41(1):126-31. PubMed PMID: 15246218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sporadic cases of acute autochthonous hepatitis E in Spain. AU - Buti,Maria, AU - Clemente-Casares,Pilar, AU - Jardi,Rosend, AU - Formiga-Cruz,Meritxell, AU - Schaper,Melanie, AU - Valdes,Auristela, AU - Rodriguez-Frias,Francisco, AU - Esteban,Rafael, AU - Girones,Rosina, PY - 2004/02/11/received PY - 2004/03/14/revised PY - 2004/03/25/accepted PY - 2004/7/13/pubmed PY - 2005/2/3/medline PY - 2004/7/13/entrez SP - 126 EP - 31 JF - Journal of hepatology JO - J Hepatol VL - 41 IS - 1 N2 - BACKGROUND/AIMS: In industrialized countries hepatitis E virus (HEV) infection is rare and its diagnosis is difficult because the utility of available tests is not well established. METHODS: We studied the presence of acute HEV infection markers in a cluster of 11 cases of acute hepatitis with IgG anti-HEV antibodies. RESULTS: Three cases were confirmed as acute hepatitis E and 8 as presumptive hepatitis E, two as a past HEV infection and one could not be determined. Three different HEV strains were identified in serum from 3 patients. Two strains belonged to genotype 3, the predominant genotype found in local urban sewage and the other strain belonged to genotype 1 and was considered an imported strain. CONCLUSIONS: Our findings demonstrate the presence of some autochthonous, sporadic acute hepatitis E cases as well as an imported case in our area and the transitory nature of virological and serological markers for HEV. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/15246218/Sporadic_cases_of_acute_autochthonous_hepatitis_E_in_Spain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168827804001308 DB - PRIME DP - Unbound Medicine ER -