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Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology.
Trends Cell Biol. 2004 Jul; 14(7):395-9.TC

Abstract

The remarkable accomplishments in developmental neurobiology within the past 60 years have depended on two things: (i) a succession of original histochemical and immunohistochemical methodologies for identifying pathways in the nervous system with increasing precision and sensitivity, and (ii) the discovery of growth factors for neurons. Growth factors are naturally occurring, essential biological mediators that promote cell growth, differentiation, survival and function in specific nerve cell populations. The discovery of nerve growth factor (NGF) by Rita Levi-Montalcini in the 1950s represents an important milestone in the processes that led to modern cell biology. NGF was the first growth factor identified, for its action on the morphological differentiation of neural-crest-derived nerve cells. Later, its effect on neuronal cells of the peripheral and central nervous systems, and on several non-neuronal cells was also determined. Thus, Levi-Montalcini's work on NGF represents, as acknowledged by the Nobel Prize Assembly in its press release of 13 October 1986, "a fascinating example of how a skilled observer can create a concept out of apparent chaos".

Authors+Show Affiliations

Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 15, 00137 Rome, Italy. aloe@in.rm.cnr.it

Pub Type(s)

Biography
Historical Article
Journal Article
Portrait

Language

eng

PubMed ID

15246433

Citation

Aloe, Luigi. "Rita Levi-Montalcini: the Discovery of Nerve Growth Factor and Modern Neurobiology." Trends in Cell Biology, vol. 14, no. 7, 2004, pp. 395-9.
Aloe L. Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology. Trends Cell Biol. 2004;14(7):395-9.
Aloe, L. (2004). Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology. Trends in Cell Biology, 14(7), 395-9.
Aloe L. Rita Levi-Montalcini: the Discovery of Nerve Growth Factor and Modern Neurobiology. Trends Cell Biol. 2004;14(7):395-9. PubMed PMID: 15246433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology. A1 - Aloe,Luigi, PY - 2004/7/13/pubmed PY - 2005/2/4/medline PY - 2004/7/13/entrez SP - 395 EP - 9 JF - Trends in cell biology JO - Trends Cell Biol VL - 14 IS - 7 N2 - The remarkable accomplishments in developmental neurobiology within the past 60 years have depended on two things: (i) a succession of original histochemical and immunohistochemical methodologies for identifying pathways in the nervous system with increasing precision and sensitivity, and (ii) the discovery of growth factors for neurons. Growth factors are naturally occurring, essential biological mediators that promote cell growth, differentiation, survival and function in specific nerve cell populations. The discovery of nerve growth factor (NGF) by Rita Levi-Montalcini in the 1950s represents an important milestone in the processes that led to modern cell biology. NGF was the first growth factor identified, for its action on the morphological differentiation of neural-crest-derived nerve cells. Later, its effect on neuronal cells of the peripheral and central nervous systems, and on several non-neuronal cells was also determined. Thus, Levi-Montalcini's work on NGF represents, as acknowledged by the Nobel Prize Assembly in its press release of 13 October 1986, "a fascinating example of how a skilled observer can create a concept out of apparent chaos". SN - 0962-8924 UR - https://www.unboundmedicine.com/medline/citation/15246433/Rita_Levi_Montalcini:_the_discovery_of_nerve_growth_factor_and_modern_neurobiology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0962892404001436 DB - PRIME DP - Unbound Medicine ER -