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Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse.
Neurosci Lett. 2004 Jul 29; 365(3):157-61.NL

Abstract

An unbiased conditioned place preference paradigm was used to evaluate the reward effect of selective endogenous mu-opioid ligands, endomorphin-1 and endomorphin-2, in male CD-1 mice. Pre- and post-conditioning free-movement were measured on day 1 and day 5, respectively. Conditioning sessions were conducted twice daily from day 2 through day 4 consisting of the alternate injection of conditioning drug or vehicle. Intracerebroventricular (i.c.v.) injection of endomorphin-1 (0.3-10 microg) induced place preference in a dose-dependent manner; whereas, endomorphin-2 (1-10 microg) dose-dependently induced place aversion. Both endomorphin-1-induced place preference and endomorphin-2-induced place aversion were blocked by pretreatment i.c.v. with mu-opioid receptor antagonist, beta-funaltrexamine. Selective delta-opioid receptor antagonist, naltrindole, co-administered i.c.v. with endomorphin-1 or endomorphin-2 did not affect reward effect. However, endomorphin-2-induced place aversion, but not endomorphin-1-induced place preference, was blocked by the i.c.v.-administered selective kappa-opioid receptor antagonist, WIN 44,441-3. It is concluded that endomorphin-1 produces conditioned place preference, which is mediated by the stimulation of mu-, but not delta- or kappa-opioid receptors, while endomorphin-2 produces conditioned place aversion, which is mediated by the stimulation of mu- and kappa-, but not delta-opioid receptors.

Authors+Show Affiliations

Department of Anesthesiology, Medical College of Wisconsin, Medical Education Building, M4308 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15246539

Citation

Wu, Hsiang-en, et al. "Opposite Conditioned Place Preference Responses to Endomorphin-1 and Endomorphin-2 in the Mouse." Neuroscience Letters, vol. 365, no. 3, 2004, pp. 157-61.
Wu HE, MacDougall RS, Clithero AD, et al. Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse. Neurosci Lett. 2004;365(3):157-61.
Wu, H. E., MacDougall, R. S., Clithero, A. D., Leitermann, R. J., Terashvili, M., & Tseng, L. F. (2004). Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse. Neuroscience Letters, 365(3), 157-61.
Wu HE, et al. Opposite Conditioned Place Preference Responses to Endomorphin-1 and Endomorphin-2 in the Mouse. Neurosci Lett. 2004 Jul 29;365(3):157-61. PubMed PMID: 15246539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse. AU - Wu,Hsiang-en, AU - MacDougall,Ryan S, AU - Clithero,Andrew D, AU - Leitermann,Randy J, AU - Terashvili,Maia, AU - Tseng,Leon F, PY - 2003/09/05/received PY - 2004/03/28/revised PY - 2004/03/31/accepted PY - 2004/7/13/pubmed PY - 2004/8/10/medline PY - 2004/7/13/entrez SP - 157 EP - 61 JF - Neuroscience letters JO - Neurosci Lett VL - 365 IS - 3 N2 - An unbiased conditioned place preference paradigm was used to evaluate the reward effect of selective endogenous mu-opioid ligands, endomorphin-1 and endomorphin-2, in male CD-1 mice. Pre- and post-conditioning free-movement were measured on day 1 and day 5, respectively. Conditioning sessions were conducted twice daily from day 2 through day 4 consisting of the alternate injection of conditioning drug or vehicle. Intracerebroventricular (i.c.v.) injection of endomorphin-1 (0.3-10 microg) induced place preference in a dose-dependent manner; whereas, endomorphin-2 (1-10 microg) dose-dependently induced place aversion. Both endomorphin-1-induced place preference and endomorphin-2-induced place aversion were blocked by pretreatment i.c.v. with mu-opioid receptor antagonist, beta-funaltrexamine. Selective delta-opioid receptor antagonist, naltrindole, co-administered i.c.v. with endomorphin-1 or endomorphin-2 did not affect reward effect. However, endomorphin-2-induced place aversion, but not endomorphin-1-induced place preference, was blocked by the i.c.v.-administered selective kappa-opioid receptor antagonist, WIN 44,441-3. It is concluded that endomorphin-1 produces conditioned place preference, which is mediated by the stimulation of mu-, but not delta- or kappa-opioid receptors, while endomorphin-2 produces conditioned place aversion, which is mediated by the stimulation of mu- and kappa-, but not delta-opioid receptors. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15246539/Opposite_conditioned_place_preference_responses_to_endomorphin_1_and_endomorphin_2_in_the_mouse_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394004005397 DB - PRIME DP - Unbound Medicine ER -