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A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial.
Am J Cardiol 2004; 94(2):222-7AJ

Abstract

This study presents an extensive analysis of the effects on blood pressure (BP) of changes in sodium intake over a wide array of subgroups, including joint subgroups defined by age and hypertension status, race or ethnicity and hypertension status, and gender and race or ethnicity. Participants were given 3 levels of sodium (50, 100, and 150 mmol/2,100 kcal) for 30 days while consuming the Dietary Approaches to Stop Hypertension (DASH) diet (rich in fruits, vegetables, and low-fat dairy) or a more typical American diet. Within each diet and subgroup, there was a general pattern such that the lower the sodium level, the greater the mean reduction in BP. Sodium reduction from 100 to 50 mmol/2,100 kcal generally had twice the effect on BP as reduction from 150 to 100 mmol/2,100 kcal. Age had a strong and graded influence on the effect of sodium within the typical and DASH diets, respectively: -4.8 and -1.0 mm Hg systolic for 23 to 41 years, -5.9 and -1.8 mm Hg for 42 to 47 years, -7.5 and -4.3 mm Hg for 48 to 54 years, and -8.1 and -6.0 mm Hg for 55 to 76 years. The influence of age on the effect of sodium reduction was particularly strong in nonhypertensive patients: -3.7 mm Hg systolic for <45 years and -7.0 mm Hg for >45 years with the typical diet and -0.7 and -2.8 mm Hg with the DASH diet. Reduced sodium intake and the DASH diet should be advocated for the prevention and treatment of high BP, particularly because the benefits to BP strengthen as subjects enter middle age, when the rate of cardiovascular disease increases sharply.

Authors+Show Affiliations

Pennington Biomedical Research Center, Baton Rouge, Lousiana, USA. brayga@pbrc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15246908

Citation

Bray, George A., et al. "A Further Subgroup Analysis of the Effects of the DASH Diet and Three Dietary Sodium Levels On Blood Pressure: Results of the DASH-Sodium Trial." The American Journal of Cardiology, vol. 94, no. 2, 2004, pp. 222-7.
Bray GA, Vollmer WM, Sacks FM, et al. A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial. Am J Cardiol. 2004;94(2):222-7.
Bray, G. A., Vollmer, W. M., Sacks, F. M., Obarzanek, E., Svetkey, L. P., & Appel, L. J. (2004). A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial. The American Journal of Cardiology, 94(2), pp. 222-7.
Bray GA, et al. A Further Subgroup Analysis of the Effects of the DASH Diet and Three Dietary Sodium Levels On Blood Pressure: Results of the DASH-Sodium Trial. Am J Cardiol. 2004 Jul 15;94(2):222-7. PubMed PMID: 15246908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial. AU - Bray,George A, AU - Vollmer,William M, AU - Sacks,Frank M, AU - Obarzanek,Eva, AU - Svetkey,Laura P, AU - Appel,Lawrence J, AU - ,, PY - 2004/01/19/received PY - 2004/03/25/revised PY - 2004/03/25/accepted PY - 2004/7/13/pubmed PY - 2004/8/11/medline PY - 2004/7/13/entrez SP - 222 EP - 7 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 94 IS - 2 N2 - This study presents an extensive analysis of the effects on blood pressure (BP) of changes in sodium intake over a wide array of subgroups, including joint subgroups defined by age and hypertension status, race or ethnicity and hypertension status, and gender and race or ethnicity. Participants were given 3 levels of sodium (50, 100, and 150 mmol/2,100 kcal) for 30 days while consuming the Dietary Approaches to Stop Hypertension (DASH) diet (rich in fruits, vegetables, and low-fat dairy) or a more typical American diet. Within each diet and subgroup, there was a general pattern such that the lower the sodium level, the greater the mean reduction in BP. Sodium reduction from 100 to 50 mmol/2,100 kcal generally had twice the effect on BP as reduction from 150 to 100 mmol/2,100 kcal. Age had a strong and graded influence on the effect of sodium within the typical and DASH diets, respectively: -4.8 and -1.0 mm Hg systolic for 23 to 41 years, -5.9 and -1.8 mm Hg for 42 to 47 years, -7.5 and -4.3 mm Hg for 48 to 54 years, and -8.1 and -6.0 mm Hg for 55 to 76 years. The influence of age on the effect of sodium reduction was particularly strong in nonhypertensive patients: -3.7 mm Hg systolic for <45 years and -7.0 mm Hg for >45 years with the typical diet and -0.7 and -2.8 mm Hg with the DASH diet. Reduced sodium intake and the DASH diet should be advocated for the prevention and treatment of high BP, particularly because the benefits to BP strengthen as subjects enter middle age, when the rate of cardiovascular disease increases sharply. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/15246908/A_further_subgroup_analysis_of_the_effects_of_the_DASH_diet_and_three_dietary_sodium_levels_on_blood_pressure:_results_of_the_DASH_Sodium_Trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002914904005181 DB - PRIME DP - Unbound Medicine ER -