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A prospective study of diet and benign breast disease.

Abstract

Much attention has been paid to the relation between diet and breast cancer risk. Because benign breast disease (BBD), particularly atypical hyperplasia (AH), is a marker of increased breast cancer risk, studies of diet and BBD may provide evidence about the effect of diet at an early stage in the process of breast carcinogenesis. We evaluated the relationship between fat, fiber, antioxidant and caffeine intake and incidence of non-proliferative BBD, proliferative BBD without atypia and AH in the Nurses' Health Study II. We calculated rate ratios (RR) and 95% confidence intervals (95% CI) for each quartile of energy-adjusted intake using the lowest quartile as reference. There was no increase in risk of BBD with increasing fat intake, rather increasing vegetable fat was associated with a significant reduction in the rate of proliferative BBD without atypia. There was no significant association between any type of BBD and micronutrient intake. High caffeine consumption was positively associated (RR = 2.46, 95% CI 1.11-5.49 for the highest quartile), and use of multivitamin supplements inversely associated (RR = 0.57, 95% CI 0.33-0.98) with risk of AH although these analyses were based on small numbers. These data do not support the hypothesis that higher fat consumption increases risk of BBD, with or without atypia, and also provide little evidence for a major role of antioxidants in the development of breast disease. They do, however, raise the possibility that high caffeine intake may increase, and use of vitamin supplements may decrease risk of developing AH.

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  • Authors+Show Affiliations

    ,

    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia.

    , , , , , ,

    Source

    MeSH

    Adult
    Antioxidants
    Breast Diseases
    Breast Neoplasms
    Diet Surveys
    Dietary Fats
    Dietary Fiber
    Dietary Supplements
    Female
    Humans
    Hyperplasia
    Middle Aged
    Nurses
    Prospective Studies
    Risk Factors
    United States
    Vitamins
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15247120

    Citation

    Webb, Penelope M., et al. "A Prospective Study of Diet and Benign Breast Disease." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 7, 2004, pp. 1106-13.
    Webb PM, Byrne C, Schnitt SJ, et al. A prospective study of diet and benign breast disease. Cancer Epidemiol Biomarkers Prev. 2004;13(7):1106-13.
    Webb, P. M., Byrne, C., Schnitt, S. J., Connolly, J. L., Jacobs, T. W., Baer, H. J., ... Colditz, G. A. (2004). A prospective study of diet and benign breast disease. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(7), pp. 1106-13.
    Webb PM, et al. A Prospective Study of Diet and Benign Breast Disease. Cancer Epidemiol Biomarkers Prev. 2004;13(7):1106-13. PubMed PMID: 15247120.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of diet and benign breast disease. AU - Webb,Penelope M, AU - Byrne,Celia, AU - Schnitt,Stuart J, AU - Connolly,James L, AU - Jacobs,Timothy W, AU - Baer,Heather J, AU - Willett,Walter C, AU - Colditz,Graham A, PY - 2004/7/13/pubmed PY - 2004/12/16/medline PY - 2004/7/13/entrez SP - 1106 EP - 13 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 7 N2 - Much attention has been paid to the relation between diet and breast cancer risk. Because benign breast disease (BBD), particularly atypical hyperplasia (AH), is a marker of increased breast cancer risk, studies of diet and BBD may provide evidence about the effect of diet at an early stage in the process of breast carcinogenesis. We evaluated the relationship between fat, fiber, antioxidant and caffeine intake and incidence of non-proliferative BBD, proliferative BBD without atypia and AH in the Nurses' Health Study II. We calculated rate ratios (RR) and 95% confidence intervals (95% CI) for each quartile of energy-adjusted intake using the lowest quartile as reference. There was no increase in risk of BBD with increasing fat intake, rather increasing vegetable fat was associated with a significant reduction in the rate of proliferative BBD without atypia. There was no significant association between any type of BBD and micronutrient intake. High caffeine consumption was positively associated (RR = 2.46, 95% CI 1.11-5.49 for the highest quartile), and use of multivitamin supplements inversely associated (RR = 0.57, 95% CI 0.33-0.98) with risk of AH although these analyses were based on small numbers. These data do not support the hypothesis that higher fat consumption increases risk of BBD, with or without atypia, and also provide little evidence for a major role of antioxidants in the development of breast disease. They do, however, raise the possibility that high caffeine intake may increase, and use of vitamin supplements may decrease risk of developing AH. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15247120/A_prospective_study_of_diet_and_benign_breast_disease_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15247120 DB - PRIME DP - Unbound Medicine ER -