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Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women.
Cancer Epidemiol Biomarkers Prev. 2004 Jul; 13(7):1156-62.CE

Abstract

Circulating hormones are associated with mammographic density, an intermediate marker of breast cancer risk. Differences in circulating hormones, including estrone and testosterone, have been observed in premenopausal women based on their capacity to metabolize daidzein, an isoflavone found predominantly in soybeans. Equol and O-desmethylangolensin (O-DMA) are products of intestinal bacterial metabolism of daidzein. There is interindividual variability in the capacity to produce daidzein metabolites; individuals can be equol producers or non-producers and O-DMA producers or non-producers. We tested the hypothesis that daidzein-metabolizing phenotypes are associated with mammographic density. Participants were recruited from among 92 sedentary, postmenopausal women, ages 50 to 75 years, who participated in a 1-year physical activity intervention. Pre-intervention mammographic density was determined using a computer-assisted, gray-scale thresholding technique. Fifty-five of these women consumed supplemental soy protein (>10 mg daidzein/d) for 3 days and collected a first-void urine sample on the fourth day to determine daidzein-metabolizing phenotypes. Equol and O-DMA concentrations were measured using gas chromatography-mass spectrometry. Associations between daidzein-metabolizing phenotypes and percent mammographic density were adjusted for age, maximum adult weight, gravidity, family history of breast cancer, and serum follicle-stimulating hormone and free testosterone concentrations. Mammographic density was 39% lower in equol producers compared with non-producers (P = 0.04). O-DMA producers had mammographic density 69% greater than non-producers (P = 0.05). These results suggest that particular intestinal bacterial profiles are associated with postmenopausal mammographic density, and these associations are not entirely explained by differences in reproductive or anthropometric characteristics or circulating hormones.

Authors+Show Affiliations

Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, USA. jlampe@fhcrc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15247126

Citation

Frankenfeld, Cara L., et al. "Mammographic Density in Relation to Daidzein-metabolizing Phenotypes in Overweight, Postmenopausal Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 7, 2004, pp. 1156-62.
Frankenfeld CL, McTiernan A, Aiello EJ, et al. Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2004;13(7):1156-62.
Frankenfeld, C. L., McTiernan, A., Aiello, E. J., Thomas, W. K., LaCroix, K., Schramm, J., Schwartz, S. M., Holt, V. L., & Lampe, J. W. (2004). Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(7), 1156-62.
Frankenfeld CL, et al. Mammographic Density in Relation to Daidzein-metabolizing Phenotypes in Overweight, Postmenopausal Women. Cancer Epidemiol Biomarkers Prev. 2004;13(7):1156-62. PubMed PMID: 15247126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women. AU - Frankenfeld,Cara L, AU - McTiernan,Anne, AU - Aiello,Erin J, AU - Thomas,Wendy K, AU - LaCroix,Kristin, AU - Schramm,Judy, AU - Schwartz,Stephen M, AU - Holt,Victoria L, AU - Lampe,Johanna W, PY - 2004/7/13/pubmed PY - 2004/12/16/medline PY - 2004/7/13/entrez SP - 1156 EP - 62 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 13 IS - 7 N2 - Circulating hormones are associated with mammographic density, an intermediate marker of breast cancer risk. Differences in circulating hormones, including estrone and testosterone, have been observed in premenopausal women based on their capacity to metabolize daidzein, an isoflavone found predominantly in soybeans. Equol and O-desmethylangolensin (O-DMA) are products of intestinal bacterial metabolism of daidzein. There is interindividual variability in the capacity to produce daidzein metabolites; individuals can be equol producers or non-producers and O-DMA producers or non-producers. We tested the hypothesis that daidzein-metabolizing phenotypes are associated with mammographic density. Participants were recruited from among 92 sedentary, postmenopausal women, ages 50 to 75 years, who participated in a 1-year physical activity intervention. Pre-intervention mammographic density was determined using a computer-assisted, gray-scale thresholding technique. Fifty-five of these women consumed supplemental soy protein (>10 mg daidzein/d) for 3 days and collected a first-void urine sample on the fourth day to determine daidzein-metabolizing phenotypes. Equol and O-DMA concentrations were measured using gas chromatography-mass spectrometry. Associations between daidzein-metabolizing phenotypes and percent mammographic density were adjusted for age, maximum adult weight, gravidity, family history of breast cancer, and serum follicle-stimulating hormone and free testosterone concentrations. Mammographic density was 39% lower in equol producers compared with non-producers (P = 0.04). O-DMA producers had mammographic density 69% greater than non-producers (P = 0.05). These results suggest that particular intestinal bacterial profiles are associated with postmenopausal mammographic density, and these associations are not entirely explained by differences in reproductive or anthropometric characteristics or circulating hormones. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15247126/Mammographic_density_in_relation_to_daidzein_metabolizing_phenotypes_in_overweight_postmenopausal_women_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15247126 DB - PRIME DP - Unbound Medicine ER -