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Acute caffeine effects on urine composition and calcium kidney stone risk in calcium stone formers.
J Urol. 2004 Aug; 172(2):555-8.JU

Abstract

PURPOSE

Caffeine increases urinary calcium (ca) excretion in nonstone formers. We designed a study to determine the effect of caffeine consumption on urinary composition in stone formers.

MATERIALS AND METHODS

A total of 39 normocalcemic patients with calcium stones consumed caffeine (6 mg/kg lean body mass) after 14 hours of fasting. Urinary composition was compared 2 hours before and 2 hours after caffeine consumption. Control subjects included 9 nonstone formers studied contemporaneously with patients plus data from 39 nonstone formers from previous studies matched to each patient by level of fasting calcium/creatinine (Cr), gender and age.

RESULTS

Caffeine increased urinary Ca/Cr, magnesium/Cr, citrate/Cr and sodium/Cr but not oxalate/Cr in stone formers and controls. The Tiselius stone risk index for calcium oxalate precipitation increased from 2.4 to 3.1 in stone formers and from 1.7 to 2.5 in nonstone formers. Of the 39 stone formers 32 had an increased Tiselius risk index after caffeine. Post-caffeine increases in Ca/Cr and Na/Cr were highly correlated.

CONCLUSIONS

Caffeine consumption may modestly increase risk of calcium oxalate stone formation.

Authors+Show Affiliations

Massey LK
Department of Food Science and Human Nutrition, Washington State University, Spokane, 99120-1495, USA. massey@wsu.edu
Sutton RA
No affiliation info available

MeSH

Acute DiseaseAdultCaffeineCalciumCalcium OxalateChemical PrecipitationCreatinineFemaleHumansKidney CalculiMaleMiddle AgedSpectrophotometry, AtomicUrine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15247728

Citation

Massey, Linda K., and Roger A L. Sutton. "Acute Caffeine Effects On Urine Composition and Calcium Kidney Stone Risk in Calcium Stone Formers." The Journal of Urology, vol. 172, no. 2, 2004, pp. 555-8.
Massey LK, Sutton RA. Acute caffeine effects on urine composition and calcium kidney stone risk in calcium stone formers. J Urol. 2004;172(2):555-8.
Massey, L. K., & Sutton, R. A. (2004). Acute caffeine effects on urine composition and calcium kidney stone risk in calcium stone formers. The Journal of Urology, 172(2), 555-8.
Massey LK, Sutton RA. Acute Caffeine Effects On Urine Composition and Calcium Kidney Stone Risk in Calcium Stone Formers. J Urol. 2004;172(2):555-8. PubMed PMID: 15247728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute caffeine effects on urine composition and calcium kidney stone risk in calcium stone formers. AU - Massey,Linda K, AU - Sutton,Roger A L, PY - 2004/7/13/pubmed PY - 2004/8/10/medline PY - 2004/7/13/entrez SP - 555 EP - 8 JF - The Journal of urology JO - J Urol VL - 172 IS - 2 N2 - PURPOSE: Caffeine increases urinary calcium (ca) excretion in nonstone formers. We designed a study to determine the effect of caffeine consumption on urinary composition in stone formers. MATERIALS AND METHODS: A total of 39 normocalcemic patients with calcium stones consumed caffeine (6 mg/kg lean body mass) after 14 hours of fasting. Urinary composition was compared 2 hours before and 2 hours after caffeine consumption. Control subjects included 9 nonstone formers studied contemporaneously with patients plus data from 39 nonstone formers from previous studies matched to each patient by level of fasting calcium/creatinine (Cr), gender and age. RESULTS: Caffeine increased urinary Ca/Cr, magnesium/Cr, citrate/Cr and sodium/Cr but not oxalate/Cr in stone formers and controls. The Tiselius stone risk index for calcium oxalate precipitation increased from 2.4 to 3.1 in stone formers and from 1.7 to 2.5 in nonstone formers. Of the 39 stone formers 32 had an increased Tiselius risk index after caffeine. Post-caffeine increases in Ca/Cr and Na/Cr were highly correlated. CONCLUSIONS: Caffeine consumption may modestly increase risk of calcium oxalate stone formation. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/15247728/Acute_caffeine_effects_on_urine_composition_and_calcium_kidney_stone_risk_in_calcium_stone_formers_ DB - PRIME DP - Unbound Medicine ER -