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Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.
Pharmazie. 2004 Jun; 59(6):446-52.P

Abstract

A new HPLC-method for the separation of medium polar and nonpolar compounds in preparations of Valeriana officinalis was established for stability control. Powdered valerian root and a commercial ethanolic valerian extract were investigated for apparent differences in stability behaviour. Storage conditions were chosen according to the ICH-guidelines. Changes in composition of valerenic acids and lignans were observed depending on storage conditions and packaging materials. Hydroxyvalerenic acid, pinoresinol and hydroxypinoresinol were identified as degradation products in Valerian root, especially during accelerated testing. Ethanolic extracts appeared not to be as sensitive for chemical degradation under climatic influences compared to the crude plant material, and showed no increase in the amounts of lignan-aglyka. In comparison, extracts showed high sensitivity on changes of physical properties like loss on drying and viscosity.

Authors+Show Affiliations

Department of Pharmaceutical Biology, Institute of Pharmacy, University of Regensburg, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15248459

Citation

Goppel, M, and G Franz. "Stability Control of Valerian Ground Material and Extracts: a New HPLC-method for the Routine Quantification of Valerenic Acids and Lignans." Die Pharmazie, vol. 59, no. 6, 2004, pp. 446-52.
Goppel M, Franz G. Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. Pharmazie. 2004;59(6):446-52.
Goppel, M., & Franz, G. (2004). Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. Die Pharmazie, 59(6), 446-52.
Goppel M, Franz G. Stability Control of Valerian Ground Material and Extracts: a New HPLC-method for the Routine Quantification of Valerenic Acids and Lignans. Pharmazie. 2004;59(6):446-52. PubMed PMID: 15248459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. AU - Goppel,M, AU - Franz,G, PY - 2004/7/14/pubmed PY - 2004/8/7/medline PY - 2004/7/14/entrez SP - 446 EP - 52 JF - Die Pharmazie JO - Pharmazie VL - 59 IS - 6 N2 - A new HPLC-method for the separation of medium polar and nonpolar compounds in preparations of Valeriana officinalis was established for stability control. Powdered valerian root and a commercial ethanolic valerian extract were investigated for apparent differences in stability behaviour. Storage conditions were chosen according to the ICH-guidelines. Changes in composition of valerenic acids and lignans were observed depending on storage conditions and packaging materials. Hydroxyvalerenic acid, pinoresinol and hydroxypinoresinol were identified as degradation products in Valerian root, especially during accelerated testing. Ethanolic extracts appeared not to be as sensitive for chemical degradation under climatic influences compared to the crude plant material, and showed no increase in the amounts of lignan-aglyka. In comparison, extracts showed high sensitivity on changes of physical properties like loss on drying and viscosity. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15248459/Stability_control_of_valerian_ground_material_and_extracts:_a_new_HPLC_method_for_the_routine_quantification_of_valerenic_acids_and_lignans_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -