Tags

Type your tag names separated by a space and hit enter

Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary Events.
Arch Intern Med. 2004 Jul 12; 164(13):1457-63.AI

Abstract

BACKGROUND

There are limited data describing the presenting characteristics, management, and outcomes of diabetic and nondiabetic patients with an acute coronary syndrome (ACS).

OBJECTIVE

To examine differences in these factors, patients with ST-segment elevation acute myocardial infarction, non-ST-segment elevation acute myocardial infarction, and unstable angina were enrolled in a large multinational coronary disease registry.

METHODS

The Global Registry of Acute Coronary Events is a prospective observational study of patients hospitalized with an ACS at 94 hospitals in 14 countries. The study sample consisted of 5403 patients with ST-segment elevation acute myocardial infarction, 4725 with non-ST-segment elevation acute myocardial infarction, and 5988 with unstable angina.

RESULTS

Approximately 1 in 4 patients presented to participating hospitals with a history of diabetes. Patients with diabetes were older, more often women, with a greater prevalence of comorbidities, and they were less likely to be treated with effective cardiac therapies than nondiabetic patients. Patients with diabetes who developed an ACS were at increased risk for each hospital outcome examined including heart failure, renal failure, cardiogenic shock, and death. These differences remained after adjustment for potentially confounding prognostic factors.

CONCLUSIONS

A considerable proportion of patients with an ACS has diabetes and is at increased risk for adverse outcomes compared with patients without diabetes. There are certain proven therapeutic strategies that remain underused in the diabetic population. A more widespread awareness of this increased risk and a more diligent use of proven cardiac treatment approaches are indicated for patients with diabetes who develop an ACS.

Authors+Show Affiliations

Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester 01655, USA. franklik@ummhc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15249356

Citation

Franklin, Kristen, et al. "Implications of Diabetes in Patients With Acute Coronary Syndromes. the Global Registry of Acute Coronary Events." Archives of Internal Medicine, vol. 164, no. 13, 2004, pp. 1457-63.
Franklin K, Goldberg RJ, Spencer F, et al. Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary Events. Arch Intern Med. 2004;164(13):1457-63.
Franklin, K., Goldberg, R. J., Spencer, F., Klein, W., Budaj, A., Brieger, D., Marre, M., Steg, P. G., Gowda, N., & Gore, J. M. (2004). Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary Events. Archives of Internal Medicine, 164(13), 1457-63.
Franklin K, et al. Implications of Diabetes in Patients With Acute Coronary Syndromes. the Global Registry of Acute Coronary Events. Arch Intern Med. 2004 Jul 12;164(13):1457-63. PubMed PMID: 15249356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary Events. AU - Franklin,Kristen, AU - Goldberg,Robert J, AU - Spencer,Frederick, AU - Klein,Werner, AU - Budaj,Andrzej, AU - Brieger,David, AU - Marre,Michel, AU - Steg,Philippe Gabriel, AU - Gowda,Neelam, AU - Gore,Joel M, AU - ,, PY - 2004/7/14/pubmed PY - 2004/9/24/medline PY - 2004/7/14/entrez SP - 1457 EP - 63 JF - Archives of internal medicine JO - Arch Intern Med VL - 164 IS - 13 N2 - BACKGROUND: There are limited data describing the presenting characteristics, management, and outcomes of diabetic and nondiabetic patients with an acute coronary syndrome (ACS). OBJECTIVE: To examine differences in these factors, patients with ST-segment elevation acute myocardial infarction, non-ST-segment elevation acute myocardial infarction, and unstable angina were enrolled in a large multinational coronary disease registry. METHODS: The Global Registry of Acute Coronary Events is a prospective observational study of patients hospitalized with an ACS at 94 hospitals in 14 countries. The study sample consisted of 5403 patients with ST-segment elevation acute myocardial infarction, 4725 with non-ST-segment elevation acute myocardial infarction, and 5988 with unstable angina. RESULTS: Approximately 1 in 4 patients presented to participating hospitals with a history of diabetes. Patients with diabetes were older, more often women, with a greater prevalence of comorbidities, and they were less likely to be treated with effective cardiac therapies than nondiabetic patients. Patients with diabetes who developed an ACS were at increased risk for each hospital outcome examined including heart failure, renal failure, cardiogenic shock, and death. These differences remained after adjustment for potentially confounding prognostic factors. CONCLUSIONS: A considerable proportion of patients with an ACS has diabetes and is at increased risk for adverse outcomes compared with patients without diabetes. There are certain proven therapeutic strategies that remain underused in the diabetic population. A more widespread awareness of this increased risk and a more diligent use of proven cardiac treatment approaches are indicated for patients with diabetes who develop an ACS. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15249356/Implications_of_diabetes_in_patients_with_acute_coronary_syndromes__The_Global_Registry_of_Acute_Coronary_Events_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.164.13.1457 DB - PRIME DP - Unbound Medicine ER -