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CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure.
Circulation. 2004 Sep 07; 110(10):1209-12.Circ

Abstract

BACKGROUND

Peripheral blood CD34(+) cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage. Despite the occurrence of endothelial dysfunction in heart failure (HF), no data are available on EPC mobilization in this setting. We investigated the pattern of CD34(+) cells and EPC mobilization during HF and their correlation with the severity and origin of the disease.

METHODS AND RESULTS

Peripheral blood CD34(+) cells (n=91) and EPCs (n=41), assessed both as CD34(+) cells coexpressing AC133 and vascular endothelial growth factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in HF patients (mean age 67+/-11 years) and 45 gender- and age-matched controls. Tumor necrosis factor-alpha (TNF-alpha) and its receptors (sTNFR-1 and sTNFR-2), VEGF, stromal derived factor-1 (SDF-1), granulocyte-colony stimulating factor (G-CSF), and B-type natriuretic peptide were also measured. CD34(+) cells, EPCs, TNF-alpha and receptors, VEGF, SDF-1, and B-type natriuretic peptide were increased in HF. CD34(+) cells and EPCs were inversely related to functional class and to TNF-alpha, being decreased in New York Heart Association class IV compared with class I and II and controls. No role was found for the origin of the disease.

CONCLUSIONS

CD34(+) cells and EPC mobilization occurs in HF and shows a biphasic response, with elevation and depression in the early and advanced phases, respectively. This could be related to the myelosuppressive role of TNF-alpha.

Authors+Show Affiliations

University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Gussago, Italy. vlgmrc@unife.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15249502

Citation

Valgimigli, Marco, et al. "CD34+ and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure." Circulation, vol. 110, no. 10, 2004, pp. 1209-12.
Valgimigli M, Rigolin GM, Fucili A, et al. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation. 2004;110(10):1209-12.
Valgimigli, M., Rigolin, G. M., Fucili, A., Porta, M. D., Soukhomovskaia, O., Malagutti, P., Bugli, A. M., Bragotti, L. Z., Francolini, G., Mauro, E., Castoldi, G., & Ferrari, R. (2004). CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation, 110(10), 1209-12.
Valgimigli M, et al. CD34+ and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure. Circulation. 2004 Sep 7;110(10):1209-12. PubMed PMID: 15249502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. AU - Valgimigli,Marco, AU - Rigolin,Gian Matteo, AU - Fucili,Alessandro, AU - Porta,Matteo Della, AU - Soukhomovskaia,Olga, AU - Malagutti,Patrizia, AU - Bugli,Anna Maria, AU - Bragotti,Letizia Zenone, AU - Francolini,Gloria, AU - Mauro,Endri, AU - Castoldi,Gianluigi, AU - Ferrari,Roberto, Y1 - 2004/07/12/ PY - 2004/7/14/pubmed PY - 2006/4/8/medline PY - 2004/7/14/entrez SP - 1209 EP - 12 JF - Circulation JO - Circulation VL - 110 IS - 10 N2 - BACKGROUND: Peripheral blood CD34(+) cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage. Despite the occurrence of endothelial dysfunction in heart failure (HF), no data are available on EPC mobilization in this setting. We investigated the pattern of CD34(+) cells and EPC mobilization during HF and their correlation with the severity and origin of the disease. METHODS AND RESULTS: Peripheral blood CD34(+) cells (n=91) and EPCs (n=41), assessed both as CD34(+) cells coexpressing AC133 and vascular endothelial growth factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in HF patients (mean age 67+/-11 years) and 45 gender- and age-matched controls. Tumor necrosis factor-alpha (TNF-alpha) and its receptors (sTNFR-1 and sTNFR-2), VEGF, stromal derived factor-1 (SDF-1), granulocyte-colony stimulating factor (G-CSF), and B-type natriuretic peptide were also measured. CD34(+) cells, EPCs, TNF-alpha and receptors, VEGF, SDF-1, and B-type natriuretic peptide were increased in HF. CD34(+) cells and EPCs were inversely related to functional class and to TNF-alpha, being decreased in New York Heart Association class IV compared with class I and II and controls. No role was found for the origin of the disease. CONCLUSIONS: CD34(+) cells and EPC mobilization occurs in HF and shows a biphasic response, with elevation and depression in the early and advanced phases, respectively. This could be related to the myelosuppressive role of TNF-alpha. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/15249502/CD34+_and_endothelial_progenitor_cells_in_patients_with_various_degrees_of_congestive_heart_failure_ L2 - https://www.ahajournals.org/doi/10.1161/01.CIR.0000136813.89036.21?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -