Tags

Type your tag names separated by a space and hit enter

Helicobacter pylori-CagA seropositivity and nitrite and ascorbic acid food intake as predictors for gastric cancer.
Eur J Cancer 2004; 40(11):1752-9EJ

Abstract

A hospital-based case-control study was carried out between 1994 and 1996 to evaluate the risk of gastric cancer (GC) according to Helicobacter pylori-CagA (+) seropositivity, nitrite and ascorbic acid intake. Three geographical areas of Mexico were selected on the basis of their contrasting dietary patterns and H. pylori seroprevalence. Nitrite and ascorbic acid consumption were estimated by interview among 211 cases and 454 matched controls. Serum antibodies against IgG H. pylori and CagA were detected by immunosorbent assays. The adjusted risk for GC was significantly higher among CagA+ subjects compared with those that were CagA negative (Odds Ratio (OR)=2.04 95% Confidence Interval (CI) 1.37-3.02 P for trend P < 0.001), this effect remained significant among diffuse GC cases (OR 2.05 95% CI 1.25-3-36). No significant effects due to nitrite and ascorbic consumption or interactions of these nutrients with CagA seropositivity were detected. Seropositivity to H. pylori CagA+ strains may be an independent factor for diffuse GC in Mexico.

Authors+Show Affiliations

Center for Public Health Research, National Institute of Public Health. University Avenue No. 655, Col. Santa María Ahuacatitlán, 62508 Cuernavaca, Morelos, Mexico. lizbeth@correo.insp.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15251166

Citation

López-Carrillo, Lizbeth, et al. "Helicobacter pylori-CagA Seropositivity and Nitrite and Ascorbic Acid Food Intake as Predictors for Gastric Cancer." European Journal of Cancer (Oxford, England : 1990), vol. 40, no. 11, 2004, pp. 1752-9.
López-Carrillo L, Torres-López J, Galván-Portillo M, et al. Helicobacter pylori-CagA seropositivity and nitrite and ascorbic acid food intake as predictors for gastric cancer. Eur J Cancer. 2004;40(11):1752-9.
López-Carrillo, L., Torres-López, J., Galván-Portillo, M., Muñoz, L., & López-Cervantes, M. (2004). Helicobacter pylori-CagA seropositivity and nitrite and ascorbic acid food intake as predictors for gastric cancer. European Journal of Cancer (Oxford, England : 1990), 40(11), pp. 1752-9.
López-Carrillo L, et al. Helicobacter pylori-CagA Seropositivity and Nitrite and Ascorbic Acid Food Intake as Predictors for Gastric Cancer. Eur J Cancer. 2004;40(11):1752-9. PubMed PMID: 15251166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori-CagA seropositivity and nitrite and ascorbic acid food intake as predictors for gastric cancer. AU - López-Carrillo,Lizbeth, AU - Torres-López,Javier, AU - Galván-Portillo,Marcia, AU - Muñoz,Leopoldo, AU - López-Cervantes,Malaquías, PY - 2003/11/04/received PY - 2004/04/23/revised PY - 2004/04/27/accepted PY - 2004/7/15/pubmed PY - 2004/9/17/medline PY - 2004/7/15/entrez SP - 1752 EP - 9 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 40 IS - 11 N2 - A hospital-based case-control study was carried out between 1994 and 1996 to evaluate the risk of gastric cancer (GC) according to Helicobacter pylori-CagA (+) seropositivity, nitrite and ascorbic acid intake. Three geographical areas of Mexico were selected on the basis of their contrasting dietary patterns and H. pylori seroprevalence. Nitrite and ascorbic acid consumption were estimated by interview among 211 cases and 454 matched controls. Serum antibodies against IgG H. pylori and CagA were detected by immunosorbent assays. The adjusted risk for GC was significantly higher among CagA+ subjects compared with those that were CagA negative (Odds Ratio (OR)=2.04 95% Confidence Interval (CI) 1.37-3.02 P for trend P < 0.001), this effect remained significant among diffuse GC cases (OR 2.05 95% CI 1.25-3-36). No significant effects due to nitrite and ascorbic consumption or interactions of these nutrients with CagA seropositivity were detected. Seropositivity to H. pylori CagA+ strains may be an independent factor for diffuse GC in Mexico. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/15251166/Helicobacter_pylori_CagA_seropositivity_and_nitrite_and_ascorbic_acid_food_intake_as_predictors_for_gastric_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959804904003740 DB - PRIME DP - Unbound Medicine ER -