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Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells.
FEBS Lett 2004; 570(1-3):189-94FL

Abstract

In this study, we examined the role of aldose reductase (AR) in regulating the cytotoxic effects of TNF-alpha on human umbilical vein endothelial cells. Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR abrogated AP-1 DNA binding activity and prevented the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNF-alpha. Exposure to TNF-alpha also induced apoptotic cell death, which was attenuated by AR inhibition or antisense ablation. These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.

Authors+Show Affiliations

Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15251463

Citation

Ramana, Kota V., et al. "Aldose Reductase Regulates TNF-alpha-induced Cell Signaling and Apoptosis in Vascular Endothelial Cells." FEBS Letters, vol. 570, no. 1-3, 2004, pp. 189-94.
Ramana KV, Bhatnagar A, Srivastava SK. Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett. 2004;570(1-3):189-94.
Ramana, K. V., Bhatnagar, A., & Srivastava, S. K. (2004). Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Letters, 570(1-3), pp. 189-94.
Ramana KV, Bhatnagar A, Srivastava SK. Aldose Reductase Regulates TNF-alpha-induced Cell Signaling and Apoptosis in Vascular Endothelial Cells. FEBS Lett. 2004 Jul 16;570(1-3):189-94. PubMed PMID: 15251463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. AU - Ramana,Kota V, AU - Bhatnagar,Aruni, AU - Srivastava,Satish K, PY - 2004/04/07/received PY - 2004/06/02/revised PY - 2004/06/23/accepted PY - 2004/7/15/pubmed PY - 2004/9/4/medline PY - 2004/7/15/entrez SP - 189 EP - 94 JF - FEBS letters JO - FEBS Lett. VL - 570 IS - 1-3 N2 - In this study, we examined the role of aldose reductase (AR) in regulating the cytotoxic effects of TNF-alpha on human umbilical vein endothelial cells. Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR abrogated AP-1 DNA binding activity and prevented the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNF-alpha. Exposure to TNF-alpha also induced apoptotic cell death, which was attenuated by AR inhibition or antisense ablation. These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/15251463/Aldose_reductase_regulates_TNF_alpha_induced_cell_signaling_and_apoptosis_in_vascular_endothelial_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014579304007975 DB - PRIME DP - Unbound Medicine ER -