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Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.

Abstract

OBJECTIVE

To determine whether the administration of D-chiro-inositol, a putative insulin-sensitizing drug, would affect the concentration of circulating insulin, the levels of serum androgens, and the frequency of ovulation in lean women with the polycystic ovary syndrome.

METHODS

In 20 lean women (body mass index, 20.0 to 24.4 kg/m 2) who had the polycystic ovary syndrome, treatment was initiated with either 600 mg of D-chiro-inositol or placebo orally once daily for 6 to 8 weeks. We performed oral glucose tolerance tests and measured serum sex steroids before and after therapy. To monitor for ovulation, we determined serum progesterone concentrations weekly.

RESULTS

In the 10 women given D-chiro-inositol, the mean (+/- standard error) area under the plasma insulin curve after oral administration of glucose decreased significantly from 8,343 +/- 1,149 mU/mL per min to 5,335 +/- 1,792 mU/mL per min in comparison with no significant change in the placebo group (P = 0.03 for difference between groups). Concomitantly, the serum free testosterone concentration decreased by 73% from 0.83 +/- 0.11 ng/dL to 0.22 +/- 0.03 ng/dL, a significant change in comparison with essentially no change in the placebo group (P = 0.01). Six of the 10 women (60%) in the D-chiro-inositol group ovulated in comparison with 2 of the 10 women (20%) in the placebo group (P = 0.17). Systolic (P = 0.002) and diastolic (P = 0.001) blood pressures, as well as plasma triglyceride concentrations (P = 0.001), decreased significantly in the D-chiro-inositol group in comparison with the placebo group, in which these variables either increased (blood pressure) or decreased minimally (triglycerides).

CONCLUSION

We conclude that, in lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities (increased blood pressure and hypertriglyceridemia) of syndrome X.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Medical College of Virginia, Virginia, Commonwealth University, Richmond, Virginia, USA.

    , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Blood Glucose
    Blood Pressure
    Body Mass Index
    Double-Blind Method
    Female
    Glucose Tolerance Test
    Humans
    Inositol Phosphates
    Insulin
    Insulin Antagonists
    Placebos
    Polycystic Ovary Syndrome
    Polysaccharides
    Testosterone
    Triglycerides

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15251831

    Citation

    Iuorno, Maria J., et al. "Effects of D-chiro-inositol in Lean Women With the Polycystic Ovary Syndrome." Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 8, no. 6, 2002, pp. 417-23.
    Iuorno MJ, Jakubowicz DJ, Baillargeon JP, et al. Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocr Pract. 2002;8(6):417-23.
    Iuorno, M. J., Jakubowicz, D. J., Baillargeon, J. P., Dillon, P., Gunn, R. D., Allan, G., & Nestler, J. E. (2002). Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 8(6), pp. 417-23.
    Iuorno MJ, et al. Effects of D-chiro-inositol in Lean Women With the Polycystic Ovary Syndrome. Endocr Pract. 2002;8(6):417-23. PubMed PMID: 15251831.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. AU - Iuorno,Maria J, AU - Jakubowicz,Daniela J, AU - Baillargeon,Jean-Patrice, AU - Dillon,Pamela, AU - Gunn,Ronald D, AU - Allan,Geoffrey, AU - Nestler,John E, PY - 2004/7/15/pubmed PY - 2004/8/6/medline PY - 2004/7/15/entrez SP - 417 EP - 23 JF - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JO - Endocr Pract VL - 8 IS - 6 N2 - OBJECTIVE: To determine whether the administration of D-chiro-inositol, a putative insulin-sensitizing drug, would affect the concentration of circulating insulin, the levels of serum androgens, and the frequency of ovulation in lean women with the polycystic ovary syndrome. METHODS: In 20 lean women (body mass index, 20.0 to 24.4 kg/m 2) who had the polycystic ovary syndrome, treatment was initiated with either 600 mg of D-chiro-inositol or placebo orally once daily for 6 to 8 weeks. We performed oral glucose tolerance tests and measured serum sex steroids before and after therapy. To monitor for ovulation, we determined serum progesterone concentrations weekly. RESULTS: In the 10 women given D-chiro-inositol, the mean (+/- standard error) area under the plasma insulin curve after oral administration of glucose decreased significantly from 8,343 +/- 1,149 mU/mL per min to 5,335 +/- 1,792 mU/mL per min in comparison with no significant change in the placebo group (P = 0.03 for difference between groups). Concomitantly, the serum free testosterone concentration decreased by 73% from 0.83 +/- 0.11 ng/dL to 0.22 +/- 0.03 ng/dL, a significant change in comparison with essentially no change in the placebo group (P = 0.01). Six of the 10 women (60%) in the D-chiro-inositol group ovulated in comparison with 2 of the 10 women (20%) in the placebo group (P = 0.17). Systolic (P = 0.002) and diastolic (P = 0.001) blood pressures, as well as plasma triglyceride concentrations (P = 0.001), decreased significantly in the D-chiro-inositol group in comparison with the placebo group, in which these variables either increased (blood pressure) or decreased minimally (triglycerides). CONCLUSION: We conclude that, in lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities (increased blood pressure and hypertriglyceridemia) of syndrome X. SN - 1530-891X UR - https://www.unboundmedicine.com/medline/citation/15251831/Effects_of_d_chiro_inositol_in_lean_women_with_the_polycystic_ovary_syndrome_ L2 - http://journals.aace.com/doi/10.4158/EP.8.6.417?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -