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Adolescence and the trajectory of alcohol use: basic to clinical studies.
Ann N Y Acad Sci. 2004 Jun; 1021:234-44.AN

Abstract

Emerging findings from developmentally focused research indicates subtle but important neurocognitive disadvantages among adolescents with alcohol-use disorders (AUD) as compared to teens without AUD. Even after 3 weeks of abstinence AUD youth display a 10% decrement in delayed memory functions. Neuropsychological testing of youth followed at 4 and 8 years demonstrates that heavy drinking during adolescence is associated with diminished retrieval of verbal and nonverbal material, and poorer performance on tests requiring attention skills. Alcohol withdrawal over the teen years appears to uniquely contribute to deterioration in functioning in visuospatial tasks. Brain imaging studies suggest reduced hippocampal volumes, white matter microstructure irregularities, brain response abnormalities while performing challenging cognitive tasks, and enhanced brain response when viewing alcohol cues (i.e., alcohol advertisements) among adolescents with AUD. Family characteristics such as history of alcoholism and socioeconomic status as well as personal features, including adolescent psychopathology, gender, and age of onset must be carefully considered when investigating the influence of teenage drinking on neurocognition. Further research is needed to understand how age at onset of drinking and duration of abstinence at the time of assessment affect cognitive findings. Longitudinal studies are needed to clarify neuromaturational changes associated with early alcohol exposure and patterns of resiliency. Although the magnitude of alcohol-related effects observed in adolescents' neurocognition is relatively modest, the implications are major given the prevalence of alcohol involvement, and the important educational, occupational, and social transitions that occur during adolescence.

Authors+Show Affiliations

University of California San Diego, Department of Psychology, 9500 Gilman Drive, San Diego, CA 92093, USA. sanbrown@ucsd.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15251893

Citation

Brown, Sandra A., and Susan F. Tapert. "Adolescence and the Trajectory of Alcohol Use: Basic to Clinical Studies." Annals of the New York Academy of Sciences, vol. 1021, 2004, pp. 234-44.
Brown SA, Tapert SF. Adolescence and the trajectory of alcohol use: basic to clinical studies. Ann N Y Acad Sci. 2004;1021:234-44.
Brown, S. A., & Tapert, S. F. (2004). Adolescence and the trajectory of alcohol use: basic to clinical studies. Annals of the New York Academy of Sciences, 1021, 234-44.
Brown SA, Tapert SF. Adolescence and the Trajectory of Alcohol Use: Basic to Clinical Studies. Ann N Y Acad Sci. 2004;1021:234-44. PubMed PMID: 15251893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adolescence and the trajectory of alcohol use: basic to clinical studies. AU - Brown,Sandra A, AU - Tapert,Susan F, PY - 2004/7/15/pubmed PY - 2004/8/24/medline PY - 2004/7/15/entrez SP - 234 EP - 44 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1021 N2 - Emerging findings from developmentally focused research indicates subtle but important neurocognitive disadvantages among adolescents with alcohol-use disorders (AUD) as compared to teens without AUD. Even after 3 weeks of abstinence AUD youth display a 10% decrement in delayed memory functions. Neuropsychological testing of youth followed at 4 and 8 years demonstrates that heavy drinking during adolescence is associated with diminished retrieval of verbal and nonverbal material, and poorer performance on tests requiring attention skills. Alcohol withdrawal over the teen years appears to uniquely contribute to deterioration in functioning in visuospatial tasks. Brain imaging studies suggest reduced hippocampal volumes, white matter microstructure irregularities, brain response abnormalities while performing challenging cognitive tasks, and enhanced brain response when viewing alcohol cues (i.e., alcohol advertisements) among adolescents with AUD. Family characteristics such as history of alcoholism and socioeconomic status as well as personal features, including adolescent psychopathology, gender, and age of onset must be carefully considered when investigating the influence of teenage drinking on neurocognition. Further research is needed to understand how age at onset of drinking and duration of abstinence at the time of assessment affect cognitive findings. Longitudinal studies are needed to clarify neuromaturational changes associated with early alcohol exposure and patterns of resiliency. Although the magnitude of alcohol-related effects observed in adolescents' neurocognition is relatively modest, the implications are major given the prevalence of alcohol involvement, and the important educational, occupational, and social transitions that occur during adolescence. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/15251893/Adolescence_and_the_trajectory_of_alcohol_use:_basic_to_clinical_studies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2004&volume=1021&spage=234 DB - PRIME DP - Unbound Medicine ER -