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Perceived mental health at the start of dialysis as a predictor of morbidity and mortality in patients with end-stage renal disease (CALVIDIA Study).
Nephrol Dial Transplant. 2004 Sep; 19(9):2347-53.ND

Abstract

BACKGROUND

Health-related quality of life may affect morbidity and survival in end-stage renal disease, but it is not clear whether coexisting comorbidity and other known prognostic variables could account for such an association.

METHODS

To study the relationship between health-related quality of life and morbidity and survival, we carried out an inception cohort study in patients starting chronic dialysis, mostly diabetics, with a follow-up of 1-3 years in 34 Spanish hospitals. Health-related quality of life was measured by the SF-36 Health Survey and Karnofsky scale. Charlson age-comorbidity index and other prognostic clinical variables were measured concurrently. The primary outcome variable was time until death and the secondary outcome was hospitalization days.

RESULTS

Of 318 patients enrolled (208 diabetics), with a median follow-up of 771 days, 80 died. In the unadjusted analysis, all-cause mortality was associated with lower SF-36 physical and mental component scores and Karnofsky scale. In the adjusted analysis, SF-36 mental component score predicted all-cause mortality (hazard ratio for a 10 point decrease: 1.28; 95% confidence interval: 1.05-1.56). The SF-36 mental component score also predicted more hospitalization days (adjusted risk ratio of each additional hospital day associated with every 10 point decrease: 1.25; 95% confidence interval: 1.08-1.45). Among diabetics, both the SF-36 physical and mental components predicted mortality and hospitalization days.

CONCLUSIONS

In end-stage renal disease, perceived mental health is an independent predictor of mortality and morbidity, mainly among diabetics patients.

Authors+Show Affiliations

López Revuelta K
Unidad de Epidemiología Clínica, Hospital Universitario Clínica Puerta de Hierro, San Martín de Porres 4, 28035 Madrid, Spain. klopez@fhalcorcon.es
García López FJ
No affiliation info available
de Alvaro Moreno F
No affiliation info available
Alonso J
No affiliation info available

MeSH

Cohort StudiesComorbidityDiabetes MellitusDialysisFemaleHealth Status IndicatorsHumansKidney Failure, ChronicMaleMental DisordersMental HealthMiddle AgedPredictive Value of TestsQuality of LifeSpainSurvival Analysis

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15252167

Citation

López Revuelta, Katia, et al. "Perceived Mental Health at the Start of Dialysis as a Predictor of Morbidity and Mortality in Patients With End-stage Renal Disease (CALVIDIA Study)." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 19, no. 9, 2004, pp. 2347-53.
López Revuelta K, García López FJ, de Alvaro Moreno F, et al. Perceived mental health at the start of dialysis as a predictor of morbidity and mortality in patients with end-stage renal disease (CALVIDIA Study). Nephrol Dial Transplant. 2004;19(9):2347-53.
López Revuelta, K., García López, F. J., de Alvaro Moreno, F., & Alonso, J. (2004). Perceived mental health at the start of dialysis as a predictor of morbidity and mortality in patients with end-stage renal disease (CALVIDIA Study). Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 19(9), 2347-53.
López Revuelta K, et al. Perceived Mental Health at the Start of Dialysis as a Predictor of Morbidity and Mortality in Patients With End-stage Renal Disease (CALVIDIA Study). Nephrol Dial Transplant. 2004;19(9):2347-53. PubMed PMID: 15252167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perceived mental health at the start of dialysis as a predictor of morbidity and mortality in patients with end-stage renal disease (CALVIDIA Study). AU - López Revuelta,Katia, AU - García López,Fernando J, AU - de Alvaro Moreno,Fernando, AU - Alonso,Jordi, Y1 - 2004/07/13/ PY - 2004/7/15/pubmed PY - 2004/12/31/medline PY - 2004/7/15/entrez SP - 2347 EP - 53 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 19 IS - 9 N2 - BACKGROUND: Health-related quality of life may affect morbidity and survival in end-stage renal disease, but it is not clear whether coexisting comorbidity and other known prognostic variables could account for such an association. METHODS: To study the relationship between health-related quality of life and morbidity and survival, we carried out an inception cohort study in patients starting chronic dialysis, mostly diabetics, with a follow-up of 1-3 years in 34 Spanish hospitals. Health-related quality of life was measured by the SF-36 Health Survey and Karnofsky scale. Charlson age-comorbidity index and other prognostic clinical variables were measured concurrently. The primary outcome variable was time until death and the secondary outcome was hospitalization days. RESULTS: Of 318 patients enrolled (208 diabetics), with a median follow-up of 771 days, 80 died. In the unadjusted analysis, all-cause mortality was associated with lower SF-36 physical and mental component scores and Karnofsky scale. In the adjusted analysis, SF-36 mental component score predicted all-cause mortality (hazard ratio for a 10 point decrease: 1.28; 95% confidence interval: 1.05-1.56). The SF-36 mental component score also predicted more hospitalization days (adjusted risk ratio of each additional hospital day associated with every 10 point decrease: 1.25; 95% confidence interval: 1.08-1.45). Among diabetics, both the SF-36 physical and mental components predicted mortality and hospitalization days. CONCLUSIONS: In end-stage renal disease, perceived mental health is an independent predictor of mortality and morbidity, mainly among diabetics patients. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/15252167/Perceived_mental_health_at_the_start_of_dialysis_as_a_predictor_of_morbidity_and_mortality_in_patients_with_end_stage_renal_disease__CALVIDIA_Study__ DB - PRIME DP - Unbound Medicine ER -