Tags

Type your tag names separated by a space and hit enter

Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC).
Int J Cancer 2004; 111(5):762-71IJ

Abstract

The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal and 103,344 postmenopausal women from 9 European countries, taking part in the EPIC study. RRs from Cox regression models were calculated, using measured height, weight, BMI and waist and hip circumferences; categorized by cohort-wide quintiles; and expressed as continuous variables, adjusted for study center, age and other risk factors. During 4.7 years of follow-up, 1,879 incident invasive breast cancers were identified. In postmenopausal women, current HRT modified the body size-breast cancer association. Among nonusers, weight, BMI and hip circumference were positively associated with breast cancer risk (all ptrend < or = 0.002); obese women (BMI > 30) had a 31% excess risk compared to women with BMI < 25. Among HRT users, body measures were inversely but nonsignificantly associated with breast cancer. Excess breast cancer risk with HRT was particularly evident among lean women. Pooled RRs per height increment of 5 cm were 1.05 (95% CI 1.00-1.16) in premenopausal and 1.10 (95% CI 1.05-1.16) in postmenopausal women. Among premenopausal women, hip circumference was the only other measure significantly related to breast cancer (ptrend = 0.03), after accounting for BMI. In postmenopausal women not taking exogenous hormones, general obesity is a significant predictor of breast cancer, while abdominal fat assessed as waist-hip ratio or waist circumference was not related to excess risk when adjusted for BMI. Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer.

Authors+Show Affiliations

Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany. lahmann@mail.dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15252848

Citation

Lahmann, Petra H., et al. "Body Size and Breast Cancer Risk: Findings From the European Prospective Investigation Into Cancer and Nutrition (EPIC)." International Journal of Cancer, vol. 111, no. 5, 2004, pp. 762-71.
Lahmann PH, Hoffmann K, Allen N, et al. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer. 2004;111(5):762-71.
Lahmann, P. H., Hoffmann, K., Allen, N., van Gils, C. H., Khaw, K. T., Tehard, B., ... Riboli, E. (2004). Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). International Journal of Cancer, 111(5), pp. 762-71.
Lahmann PH, et al. Body Size and Breast Cancer Risk: Findings From the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2004 Sep 20;111(5):762-71. PubMed PMID: 15252848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). AU - Lahmann,Petra H, AU - Hoffmann,Kurt, AU - Allen,Naomi, AU - van Gils,Carla H, AU - Khaw,Kay-Tee, AU - Tehard,Bertrand, AU - Berrino,Franco, AU - Tjønneland,Anne, AU - Bigaard,Janne, AU - Olsen,Anja, AU - Overvad,Kim, AU - Clavel-Chapelon,Françoise, AU - Nagel,Gabriele, AU - Boeing,Heiner, AU - Trichopoulos,Dimitrios, AU - Economou,George, AU - Bellos,George, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Sacerdote,Carlotta, AU - Krogh,Vittorio, AU - Peeters,Petra H M, AU - Bueno-de-Mesquita,H Bas, AU - Lund,Eiliv, AU - Ardanaz,Eva, AU - Amiano,Pilar, AU - Pera,Guillem, AU - Quirós,José R, AU - Martínez,Carmen, AU - Tormo,María J, AU - Wirfält,Elisabet, AU - Berglund,Göran, AU - Hallmans,Göran, AU - Key,Timothy J, AU - Reeves,Gillian, AU - Bingham,Sheila, AU - Norat,Teresa, AU - Biessy,Carine, AU - Kaaks,Rudolf, AU - Riboli,Elio, PY - 2004/7/15/pubmed PY - 2004/9/1/medline PY - 2004/7/15/entrez SP - 762 EP - 71 JF - International journal of cancer JO - Int. J. Cancer VL - 111 IS - 5 N2 - The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal and 103,344 postmenopausal women from 9 European countries, taking part in the EPIC study. RRs from Cox regression models were calculated, using measured height, weight, BMI and waist and hip circumferences; categorized by cohort-wide quintiles; and expressed as continuous variables, adjusted for study center, age and other risk factors. During 4.7 years of follow-up, 1,879 incident invasive breast cancers were identified. In postmenopausal women, current HRT modified the body size-breast cancer association. Among nonusers, weight, BMI and hip circumference were positively associated with breast cancer risk (all ptrend < or = 0.002); obese women (BMI > 30) had a 31% excess risk compared to women with BMI < 25. Among HRT users, body measures were inversely but nonsignificantly associated with breast cancer. Excess breast cancer risk with HRT was particularly evident among lean women. Pooled RRs per height increment of 5 cm were 1.05 (95% CI 1.00-1.16) in premenopausal and 1.10 (95% CI 1.05-1.16) in postmenopausal women. Among premenopausal women, hip circumference was the only other measure significantly related to breast cancer (ptrend = 0.03), after accounting for BMI. In postmenopausal women not taking exogenous hormones, general obesity is a significant predictor of breast cancer, while abdominal fat assessed as waist-hip ratio or waist circumference was not related to excess risk when adjusted for BMI. Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15252848/Body_size_and_breast_cancer_risk:_findings_from_the_European_Prospective_Investigation_into_Cancer_And_Nutrition__EPIC__ L2 - https://doi.org/10.1002/ijc.20315 DB - PRIME DP - Unbound Medicine ER -