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Alcoholism and cancer risk: a population-based cohort study.

Abstract

The incidence of cancer was studied in a population-based cohort of 9,353 individuals (8,340 men and 1,013 women) with a discharge diagnosis of alcoholism in 1965-83, followed up for 19 years (mean 7.7). After exclusion of cancers in the first year of follow-up, 491 cancers were observed cf 343.2 expected through 1984 (standardized incidence ratio [SIR] = 1.4, 95 percent confidence interval [CI] = 1.3-1.6). A similar excess risk of cancer was seen among men (SIR = 1.4, CI = 1.3-1.6) and among women (SIR = 1.5, CI = 1.1-2.0). We observed the established associations with cancers of the oral cavity and pharynx (SIR = 4.1, CI = 2.9-5.7), esophagus (SIR = 6.8, CI = 4.5-9.9), larynx (SIR = 3.3, CI = 1.7-6.0), and lung (SIR = 2.1, CI = 1.7-2.6), although confounding by smoking likely increased these risk estimates. While there was evidence of increased risk for pancreatic cancer (SIR = 1.5, CI = 0.9-2.3), alcoholism did not elevate the incidence of cancer of the stomach (SIR = 0.9, CI = 6-1.4), large bowel (SIR = 1.1, CI = 0.8-1.5), prostate (SIR = 1.0, CI = 0.8-1.3), urinary bladder (SIR = 1.0, CI = 0.6-1.5), or of malignant melanoma (SIR = 0.9, CI = 0.3-1.9). Among women, the number of breast cancers observed was close to expected (SIR = 1.2, CI = 0.6-2.2), although a significant excess number of cervical cancers occurred (SIR = 4.2, CI = 1.5-9.1).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Links

Authors+Show Affiliations

,

Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.

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Source

Cancer causes & control : CCC 3:5 1992 Sep pg 419-25

MeSH

Aged
Alcoholism
Cohort Studies
Esophageal Neoplasms
Female
Humans
Incidence
Laryngeal Neoplasms
Liver Neoplasms
Lung Neoplasms
Male
Middle Aged
Mouth Neoplasms
Neoplasms
Risk Factors
Sweden

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1525322

Citation

Adami, H O., et al. "Alcoholism and Cancer Risk: a Population-based Cohort Study." Cancer Causes & Control : CCC, vol. 3, no. 5, 1992, pp. 419-25.
Adami HO, McLaughlin JK, Hsing AW, et al. Alcoholism and cancer risk: a population-based cohort study. Cancer Causes Control. 1992;3(5):419-25.
Adami, H. O., McLaughlin, J. K., Hsing, A. W., Wolk, A., Ekbom, A., Holmberg, L., & Persson, I. (1992). Alcoholism and cancer risk: a population-based cohort study. Cancer Causes & Control : CCC, 3(5), pp. 419-25.
Adami HO, et al. Alcoholism and Cancer Risk: a Population-based Cohort Study. Cancer Causes Control. 1992;3(5):419-25. PubMed PMID: 1525322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcoholism and cancer risk: a population-based cohort study. AU - Adami,H O, AU - McLaughlin,J K, AU - Hsing,A W, AU - Wolk,A, AU - Ekbom,A, AU - Holmberg,L, AU - Persson,I, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 419 EP - 25 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 3 IS - 5 N2 - The incidence of cancer was studied in a population-based cohort of 9,353 individuals (8,340 men and 1,013 women) with a discharge diagnosis of alcoholism in 1965-83, followed up for 19 years (mean 7.7). After exclusion of cancers in the first year of follow-up, 491 cancers were observed cf 343.2 expected through 1984 (standardized incidence ratio [SIR] = 1.4, 95 percent confidence interval [CI] = 1.3-1.6). A similar excess risk of cancer was seen among men (SIR = 1.4, CI = 1.3-1.6) and among women (SIR = 1.5, CI = 1.1-2.0). We observed the established associations with cancers of the oral cavity and pharynx (SIR = 4.1, CI = 2.9-5.7), esophagus (SIR = 6.8, CI = 4.5-9.9), larynx (SIR = 3.3, CI = 1.7-6.0), and lung (SIR = 2.1, CI = 1.7-2.6), although confounding by smoking likely increased these risk estimates. While there was evidence of increased risk for pancreatic cancer (SIR = 1.5, CI = 0.9-2.3), alcoholism did not elevate the incidence of cancer of the stomach (SIR = 0.9, CI = 6-1.4), large bowel (SIR = 1.1, CI = 0.8-1.5), prostate (SIR = 1.0, CI = 0.8-1.3), urinary bladder (SIR = 1.0, CI = 0.6-1.5), or of malignant melanoma (SIR = 0.9, CI = 0.3-1.9). Among women, the number of breast cancers observed was close to expected (SIR = 1.2, CI = 0.6-2.2), although a significant excess number of cervical cancers occurred (SIR = 4.2, CI = 1.5-9.1).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/1525322/Alcoholism_and_cancer_risk:_a_population_based_cohort_study_ L2 - https://medlineplus.gov/alcoholismandalcoholabuse.html DB - PRIME DP - Unbound Medicine ER -