Tags

Type your tag names separated by a space and hit enter

Severe acute respiratory syndrome (SARS): epidemiology and clinical features.
Postgrad Med J. 2004 Jul; 80(945):373-81.PM

Abstract

Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%-80% in the first week of the illness.

Authors+Show Affiliations

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. dschui@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15254300

Citation

Hui, D S C., et al. "Severe Acute Respiratory Syndrome (SARS): Epidemiology and Clinical Features." Postgraduate Medical Journal, vol. 80, no. 945, 2004, pp. 373-81.
Hui DS, Chan MC, Wu AK, et al. Severe acute respiratory syndrome (SARS): epidemiology and clinical features. Postgrad Med J. 2004;80(945):373-81.
Hui, D. S., Chan, M. C., Wu, A. K., & Ng, P. C. (2004). Severe acute respiratory syndrome (SARS): epidemiology and clinical features. Postgraduate Medical Journal, 80(945), 373-81.
Hui DS, et al. Severe Acute Respiratory Syndrome (SARS): Epidemiology and Clinical Features. Postgrad Med J. 2004;80(945):373-81. PubMed PMID: 15254300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe acute respiratory syndrome (SARS): epidemiology and clinical features. AU - Hui,D S C, AU - Chan,M C H, AU - Wu,A K, AU - Ng,P C, PY - 2004/7/16/pubmed PY - 2004/10/16/medline PY - 2004/7/16/entrez SP - 373 EP - 81 JF - Postgraduate medical journal JO - Postgrad Med J VL - 80 IS - 945 N2 - Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%-80% in the first week of the illness. SN - 0032-5473 UR - https://www.unboundmedicine.com/medline/citation/15254300/Severe_acute_respiratory_syndrome__SARS_:_epidemiology_and_clinical_features_ L2 - https://pmj.bmj.com/lookup/pmidlookup?view=long&pmid=15254300 DB - PRIME DP - Unbound Medicine ER -