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Effects of 6-month multivitamin supplementation on serum concentrations of alpha-tocopherol, beta-carotene, and vitamin C in healthy elderly women.
Int J Vitam Nutr Res. 2004 Mar; 74(2):161-8.IJ

Abstract

OBJECTIVE

The aim of this study was to evaluate the effect of supplementation with nutritional doses of antioxidant nutrients on the serum concentrations of ascorbic acid, alpha-tocopherol, and beta-carotene in healthy elderly women.

METHODS

The study was performed as a randomized placebo-controlled, double-blind trial. Two hundred forty-one free-living, healthy women aged 60 years and older were recruited by newspaper advertisement in Hanover, Germany and its environs. As 21 women dropped out, data of 220 women (aged 60-91 years median 63 years) were included in this evaluation. Subjects were randomly assigned to receive either a multivitamin/mineral or placebo capsule with identical appearance for six months containing 36 mg 36mg vitamin E, 150 mg vitamin C, and 9 mg beta-carotene. Serum concentrations of vitamin C, alpha-tocopherol, and beta-carotene were measured initially and after six months of supplementation. Data were analyzed with the SPSS 10.0 program.

RESULTS

Median serum concentrations of alpha-carotene and vitamin E increased significantly in the supplemented group (p=0.000), whereas no significant modifications were observed in the placebo group. Median vitamin C concentration of the supplemented group did not differ from baseline after intervention, but that of the placebo group was significantly decreased after six months (p=0.000). In comparison to estimated desirable serum concentrations of > 30 micromol/L vitamin E, 50 micromol/L vitamin C, and > 0.4 micromol/l beta-carotene at baseline, lower concentrations were found in 21.1%, 6.9%, and 1.0% of all subjects, respectively. After supplementation none of the members of the supplemented group had tocopherol concentrations below 30 micromol/L and only one woman of the supplemented group had a serum beta-carotene concentration below 0.4 micromol/L. The change in serum concentrations of vitamin C and E in the supplemented group depended on the status at baseline.

CONCLUSION

A six-month supplementation with physiological doses of antioxidant vitamins improves the blood concentration of these nutrients even in relatively well-nourished elderly women or, as seen for vitamin C, prevents reduction of serum concentrations. Prevalence of suboptimal serum concentrations can be reduced.

Authors+Show Affiliations

Institute of Food Science, Department of Applied Chemistry, University of Hanover. maike.wolters@lw.uni-hannover.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15255454

Citation

Wolters, Maike, et al. "Effects of 6-month Multivitamin Supplementation On Serum Concentrations of Alpha-tocopherol, Beta-carotene, and Vitamin C in Healthy Elderly Women." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 74, no. 2, 2004, pp. 161-8.
Wolters M, Hermann S, Hahn A. Effects of 6-month multivitamin supplementation on serum concentrations of alpha-tocopherol, beta-carotene, and vitamin C in healthy elderly women. Int J Vitam Nutr Res. 2004;74(2):161-8.
Wolters, M., Hermann, S., & Hahn, A. (2004). Effects of 6-month multivitamin supplementation on serum concentrations of alpha-tocopherol, beta-carotene, and vitamin C in healthy elderly women. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 74(2), 161-8.
Wolters M, Hermann S, Hahn A. Effects of 6-month Multivitamin Supplementation On Serum Concentrations of Alpha-tocopherol, Beta-carotene, and Vitamin C in Healthy Elderly Women. Int J Vitam Nutr Res. 2004;74(2):161-8. PubMed PMID: 15255454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 6-month multivitamin supplementation on serum concentrations of alpha-tocopherol, beta-carotene, and vitamin C in healthy elderly women. AU - Wolters,Maike, AU - Hermann,Silke, AU - Hahn,Andreas, PY - 2004/7/17/pubmed PY - 2004/7/30/medline PY - 2004/7/17/entrez SP - 161 EP - 8 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 74 IS - 2 N2 - OBJECTIVE: The aim of this study was to evaluate the effect of supplementation with nutritional doses of antioxidant nutrients on the serum concentrations of ascorbic acid, alpha-tocopherol, and beta-carotene in healthy elderly women. METHODS: The study was performed as a randomized placebo-controlled, double-blind trial. Two hundred forty-one free-living, healthy women aged 60 years and older were recruited by newspaper advertisement in Hanover, Germany and its environs. As 21 women dropped out, data of 220 women (aged 60-91 years median 63 years) were included in this evaluation. Subjects were randomly assigned to receive either a multivitamin/mineral or placebo capsule with identical appearance for six months containing 36 mg 36mg vitamin E, 150 mg vitamin C, and 9 mg beta-carotene. Serum concentrations of vitamin C, alpha-tocopherol, and beta-carotene were measured initially and after six months of supplementation. Data were analyzed with the SPSS 10.0 program. RESULTS: Median serum concentrations of alpha-carotene and vitamin E increased significantly in the supplemented group (p=0.000), whereas no significant modifications were observed in the placebo group. Median vitamin C concentration of the supplemented group did not differ from baseline after intervention, but that of the placebo group was significantly decreased after six months (p=0.000). In comparison to estimated desirable serum concentrations of > 30 micromol/L vitamin E, 50 micromol/L vitamin C, and > 0.4 micromol/l beta-carotene at baseline, lower concentrations were found in 21.1%, 6.9%, and 1.0% of all subjects, respectively. After supplementation none of the members of the supplemented group had tocopherol concentrations below 30 micromol/L and only one woman of the supplemented group had a serum beta-carotene concentration below 0.4 micromol/L. The change in serum concentrations of vitamin C and E in the supplemented group depended on the status at baseline. CONCLUSION: A six-month supplementation with physiological doses of antioxidant vitamins improves the blood concentration of these nutrients even in relatively well-nourished elderly women or, as seen for vitamin C, prevents reduction of serum concentrations. Prevalence of suboptimal serum concentrations can be reduced. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/15255454/Effects_of_6_month_multivitamin_supplementation_on_serum_concentrations_of_alpha_tocopherol_beta_carotene_and_vitamin_C_in_healthy_elderly_women_ L2 - https://econtent.hogrefe.com/doi/10.1024/0300-9831.74.2.161?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -