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Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats.
Indian J Exp Biol. 2003 Apr; 41(4):304-10.IJ

Abstract

Effect of methanolic extract of P. Pinnata roots (PPRM) was studied against various experimental gastric ulcer models and offensive and defensive gastric mucosal factors in rats. An initial dose-response study using 12.5-50 mg/kg P. Pinnata root extract, when given orally in two divided dose for 4 days + 5th full dose on the day of experiment 60 min before the experiment, indicated 25 mg/kg as an optimal regimen and was used for further study. PPRM showed significant protection against aspirin and 4 hr PL, but not against ethanol-induced gastric ulceration. It showed tendency to decrease acetic acid-induced ulcer after 10 days treatment. Ulcer protective effect of PPRM was due to augmentation of mucosal defensive factors like mucin secretion, life span of mucosal cells, mucosal cell glycoproteins, cell proliferation and prevention of lipid per oxidation rather than on the offensive acid-pepsin secretion.

Authors+Show Affiliations

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15255638

Citation

Prabha, T, et al. "Evaluation of Pongamia Pinnata Root Extract On Gastric Ulcers and Mucosal Offensive and Defensive Factors in Rats." Indian Journal of Experimental Biology, vol. 41, no. 4, 2003, pp. 304-10.
Prabha T, Dora Babu M, Priyambada S, et al. Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats. Indian J Exp Biol. 2003;41(4):304-10.
Prabha, T., Dora Babu, M., Priyambada, S., Agrawal, V. K., & Goel, R. K. (2003). Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats. Indian Journal of Experimental Biology, 41(4), 304-10.
Prabha T, et al. Evaluation of Pongamia Pinnata Root Extract On Gastric Ulcers and Mucosal Offensive and Defensive Factors in Rats. Indian J Exp Biol. 2003;41(4):304-10. PubMed PMID: 15255638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats. AU - Prabha,T, AU - Dora Babu,M, AU - Priyambada,S, AU - Agrawal,V K, AU - Goel,R K, PY - 2004/7/17/pubmed PY - 2004/8/6/medline PY - 2004/7/17/entrez SP - 304 EP - 10 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 41 IS - 4 N2 - Effect of methanolic extract of P. Pinnata roots (PPRM) was studied against various experimental gastric ulcer models and offensive and defensive gastric mucosal factors in rats. An initial dose-response study using 12.5-50 mg/kg P. Pinnata root extract, when given orally in two divided dose for 4 days + 5th full dose on the day of experiment 60 min before the experiment, indicated 25 mg/kg as an optimal regimen and was used for further study. PPRM showed significant protection against aspirin and 4 hr PL, but not against ethanol-induced gastric ulceration. It showed tendency to decrease acetic acid-induced ulcer after 10 days treatment. Ulcer protective effect of PPRM was due to augmentation of mucosal defensive factors like mucin secretion, life span of mucosal cells, mucosal cell glycoproteins, cell proliferation and prevention of lipid per oxidation rather than on the offensive acid-pepsin secretion. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/15255638/Evaluation_of_Pongamia_pinnata_root_extract_on_gastric_ulcers_and_mucosal_offensive_and_defensive_factors_in_rats_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -