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[Change of prostaglandin E2 and interleukin-12, interleukin-13 in the bronchoalveolar lavage fluid and the serum of the patients with idiopathic pulmonary fibrosis].
Zhonghua Jie He He Hu Xi Za Zhi. 2004 Jun; 27(6):378-80.ZJ

Abstract

OBJECTIVE

To detect the levels of prostaglandin E2 (PGE2) and interleukin-12 (IL-12), IL-13 in the bronchoalveolar lavage fluid (BALF) and the serum of patients with idiopathic pulmonary fibrosis (IPF) and to investigate the significance of their change in the pathogenesis of IPF.

METHODS

Radioimmunoassay (RIA) and enzyme-linked immunoadsorbent assay (ELISA) were used to detect the levels of PGE2 and IL-12, IL-13 in the BALF and the serum of patients with IPF.

RESULTS

In the BALF of patients with IPF, the levels of PGE2 (591 +/- 88) ng/L and IL-13 (38 +/- 5) ng/L were higher than that of the control group (P < 0.01), and the level of IL-12 (1.34 +/- 0.25) ng/L was lower than that of control group. In the patients with IPF, the change of IL-13 in the serum was consistent with the change in the BALF. But the levels of PGE2 (235 +/- 13) ng/L and IL-12 (2.35 +/- 0.14) ng/L in the serum showed no significant difference between the patients with IPF and the control group.

CONCLUSIONS

In the patients with IPF the increase of PGE2 may be correlated with the increase of IL-13 and the decrease of IL-12. It suggests that disequilibrium of Th1/Th2 plays an important role in the development of IPF. The increase of PGE2 in IPF is a local event rather than a systemic effect.

Authors+Show Affiliations

Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15256084

Citation

Li, Jin-Zhao, et al. "[Change of Prostaglandin E2 and Interleukin-12, Interleukin-13 in the Bronchoalveolar Lavage Fluid and the Serum of the Patients With Idiopathic Pulmonary Fibrosis]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 27, no. 6, 2004, pp. 378-80.
Li JZ, Li ZH, Kang J, et al. [Change of prostaglandin E2 and interleukin-12, interleukin-13 in the bronchoalveolar lavage fluid and the serum of the patients with idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2004;27(6):378-80.
Li, J. Z., Li, Z. H., Kang, J., Hou, X. M., & Yu, R. J. (2004). [Change of prostaglandin E2 and interleukin-12, interleukin-13 in the bronchoalveolar lavage fluid and the serum of the patients with idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 27(6), 378-80.
Li JZ, et al. [Change of Prostaglandin E2 and Interleukin-12, Interleukin-13 in the Bronchoalveolar Lavage Fluid and the Serum of the Patients With Idiopathic Pulmonary Fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2004;27(6):378-80. PubMed PMID: 15256084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Change of prostaglandin E2 and interleukin-12, interleukin-13 in the bronchoalveolar lavage fluid and the serum of the patients with idiopathic pulmonary fibrosis]. AU - Li,Jin-Zhao, AU - Li,Zhen-Hua, AU - Kang,Jian, AU - Hou,Xian-Ming, AU - Yu,Run-Jiang, PY - 2004/7/17/pubmed PY - 2006/6/16/medline PY - 2004/7/17/entrez SP - 378 EP - 80 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 27 IS - 6 N2 - OBJECTIVE: To detect the levels of prostaglandin E2 (PGE2) and interleukin-12 (IL-12), IL-13 in the bronchoalveolar lavage fluid (BALF) and the serum of patients with idiopathic pulmonary fibrosis (IPF) and to investigate the significance of their change in the pathogenesis of IPF. METHODS: Radioimmunoassay (RIA) and enzyme-linked immunoadsorbent assay (ELISA) were used to detect the levels of PGE2 and IL-12, IL-13 in the BALF and the serum of patients with IPF. RESULTS: In the BALF of patients with IPF, the levels of PGE2 (591 +/- 88) ng/L and IL-13 (38 +/- 5) ng/L were higher than that of the control group (P < 0.01), and the level of IL-12 (1.34 +/- 0.25) ng/L was lower than that of control group. In the patients with IPF, the change of IL-13 in the serum was consistent with the change in the BALF. But the levels of PGE2 (235 +/- 13) ng/L and IL-12 (2.35 +/- 0.14) ng/L in the serum showed no significant difference between the patients with IPF and the control group. CONCLUSIONS: In the patients with IPF the increase of PGE2 may be correlated with the increase of IL-13 and the decrease of IL-12. It suggests that disequilibrium of Th1/Th2 plays an important role in the development of IPF. The increase of PGE2 in IPF is a local event rather than a systemic effect. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/15256084/[Change_of_prostaglandin_E2_and_interleukin_12_interleukin_13_in_the_bronchoalveolar_lavage_fluid_and_the_serum_of_the_patients_with_idiopathic_pulmonary_fibrosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1001-0939&amp;year=2004&amp;vol=27&amp;issue=6&amp;fpage=378 DB - PRIME DP - Unbound Medicine ER -