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Rheological profile in severe and morbid obesity. Preliminary results.
Clin Hemorheol Microcirc. 2004; 30(3-4):415-8.CH

Abstract

The association of hemorheological alterations with morbid obesity remains a question of debate. In order to ascertain whether morbid obese subjects show certain hemorheological alterations which might be involved in the higher thrombotic risk which characterizes these subjects, we determine glucose, plasma lipids, apolipoproteins, fibrinogen, hematocrit, blood viscosity (Brookfield DVIII viscosimeter), both at native and corrected hematocrit of 45%, plasma viscosity (Fresenius capillary viscosimeter), erythrocyte aggregation (Myrenne aggregometer), both at stasis and at 3 s(-1) at 45% hematocrit and erythrocyte indexes in 41 morbid obese subjects (32 female, 9 male aged 33+/-10 years), and in a well matched non-obese control group (40 female, 15 male, aged 32+/-10 years). Mean BMI in the morbid obese group was 44.9+/-6.7 kg/m2 vs 23.5+/-4.8 kg/m2 in the control group (p<0.001). Morbid obese subjects when compared with the control group showed a statistically higher glucose level (p<0.001), LDL-cholesterol (p=0.019), triglycerides (p<0.001), apoB (p=0.019), apoB/A1 (p<0.001), fibrinogen (p<0.001), erythrocyte aggregation (p<0.001), and a statistically lower HDL-cholesterol (p<0.001). No differences between both groups were observed regarding total-cholesterol, plasma viscosity, blood viscosity and hematocrit (p=0.109; p=0.690; p=0.510; p=0.950), respectively. After the adjustment for BMI, differences in glucose, LDL-cholesterol, triglycerides, apoB, apoB/A1, and erythrocyte aggregation did not reach the statistical significance, and differences in fibrinogen were borderline significant (p=0.051), showing a direct effect of BMI on the detected differences between obese and non-obese. Our results suggest that in morbid obese subjects the increased fibrinogen levels and the altered lipid profile associated with their higher BMI, could in addition to its known mechanisms on haemostasis, favour both venous and arterial thrombotic events by enhancing erythrocyte aggregation.

Authors+Show Affiliations

Endocrinology Service, Dr. Peset Hospital, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15258376

Citation

Solá, Eva, et al. "Rheological Profile in Severe and Morbid Obesity. Preliminary Results." Clinical Hemorheology and Microcirculation, vol. 30, no. 3-4, 2004, pp. 415-8.
Solá E, Vayá A, Contreras T, et al. Rheological profile in severe and morbid obesity. Preliminary results. Clin Hemorheol Microcirc. 2004;30(3-4):415-8.
Solá, E., Vayá, A., Contreras, T., Falcó, C., Corella, D., Hernández, A., & Aznar, J. (2004). Rheological profile in severe and morbid obesity. Preliminary results. Clinical Hemorheology and Microcirculation, 30(3-4), 415-8.
Solá E, et al. Rheological Profile in Severe and Morbid Obesity. Preliminary Results. Clin Hemorheol Microcirc. 2004;30(3-4):415-8. PubMed PMID: 15258376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rheological profile in severe and morbid obesity. Preliminary results. AU - Solá,Eva, AU - Vayá,Amparo, AU - Contreras,Teresa, AU - Falcó,Cristina, AU - Corella,Dolores, AU - Hernández,Antonio, AU - Aznar,Justo, PY - 2004/7/20/pubmed PY - 2004/10/7/medline PY - 2004/7/20/entrez SP - 415 EP - 8 JF - Clinical hemorheology and microcirculation JO - Clin Hemorheol Microcirc VL - 30 IS - 3-4 N2 - The association of hemorheological alterations with morbid obesity remains a question of debate. In order to ascertain whether morbid obese subjects show certain hemorheological alterations which might be involved in the higher thrombotic risk which characterizes these subjects, we determine glucose, plasma lipids, apolipoproteins, fibrinogen, hematocrit, blood viscosity (Brookfield DVIII viscosimeter), both at native and corrected hematocrit of 45%, plasma viscosity (Fresenius capillary viscosimeter), erythrocyte aggregation (Myrenne aggregometer), both at stasis and at 3 s(-1) at 45% hematocrit and erythrocyte indexes in 41 morbid obese subjects (32 female, 9 male aged 33+/-10 years), and in a well matched non-obese control group (40 female, 15 male, aged 32+/-10 years). Mean BMI in the morbid obese group was 44.9+/-6.7 kg/m2 vs 23.5+/-4.8 kg/m2 in the control group (p<0.001). Morbid obese subjects when compared with the control group showed a statistically higher glucose level (p<0.001), LDL-cholesterol (p=0.019), triglycerides (p<0.001), apoB (p=0.019), apoB/A1 (p<0.001), fibrinogen (p<0.001), erythrocyte aggregation (p<0.001), and a statistically lower HDL-cholesterol (p<0.001). No differences between both groups were observed regarding total-cholesterol, plasma viscosity, blood viscosity and hematocrit (p=0.109; p=0.690; p=0.510; p=0.950), respectively. After the adjustment for BMI, differences in glucose, LDL-cholesterol, triglycerides, apoB, apoB/A1, and erythrocyte aggregation did not reach the statistical significance, and differences in fibrinogen were borderline significant (p=0.051), showing a direct effect of BMI on the detected differences between obese and non-obese. Our results suggest that in morbid obese subjects the increased fibrinogen levels and the altered lipid profile associated with their higher BMI, could in addition to its known mechanisms on haemostasis, favour both venous and arterial thrombotic events by enhancing erythrocyte aggregation. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/15258376/Rheological_profile_in_severe_and_morbid_obesity__Preliminary_results_ L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -