Tags

Type your tag names separated by a space and hit enter

Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes.
Pancreatology. 2004; 4(5):461-7.P

Abstract

AIMS

In chronic calcific pancreatitis of the tropics, etiology and relationship to developing diabetes mellitus are unknown. Some consider these cases a straightforward secondary type of diabetes, while others suggest selective beta-cell impairment. Testing pancreatic function, we investigated whether selective beta-cell impairment triggers diabetes associated with tropical pancreatitis.

METHODS

At a Bangladeshi research institute, 8 chronic tropical pancreatitis and no diabetes mellitus subjects, 14 fibrocalculous pancreatic diabetics and 27 matched healthy controls underwent arginine (endocrine pancreatic function) and secretin (exocrine pancreatic function assessment) stimulation tests.

RESULTS

All patients with clinically-diagnosed, chronic pancreatitis demonstrated pronounced exocrine pancreatic dysfunction with beta-cell functioning differing significantly between the two groups. Compared to controls, patients having tropical pancreatitis and no diabetes showed normal plasma C-peptide values at baseline and after arginine stimulation, while fibrocalculous pancreatic diabetics demonstrated a typical diabetic pattern for plasma C-peptide levels. In contrast, pancreatic alpha-cell functioning (glucagon response to arginine) was preserved in both pancreatitis groups.

CONCLUSION

A preserved pancreatic alpha-cell function in diabetics with advanced chronic pancreatitis of the tropics supports the concept of two different pathogenic mechanisms, one eliciting chronic pancreatitis and the other selective pancreatic beta-cell impairment and subsequent diabetes mellitus.

Authors+Show Affiliations

University Hospital, Department of Medicine, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15258409

Citation

Rossi, L, et al. "Diabetes Mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes." Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], vol. 4, no. 5, 2004, pp. 461-7.
Rossi L, Parvin S, Hassan Z, et al. Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. Pancreatology. 2004;4(5):461-7.
Rossi, L., Parvin, S., Hassan, Z., Hildebrand, P., Keller, U., Ali, L., Beglinger, C., Azad Khan, A. K., Whitcomb, D. C., & Gyr, N. (2004). Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], 4(5), 461-7.
Rossi L, et al. Diabetes Mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. Pancreatology. 2004;4(5):461-7. PubMed PMID: 15258409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. AU - Rossi,L, AU - Parvin,S, AU - Hassan,Z, AU - Hildebrand,P, AU - Keller,U, AU - Ali,L, AU - Beglinger,C, AU - Azad Khan,A K, AU - Whitcomb,David C, AU - Gyr,N, Y1 - 2004/07/15/ PY - 2003/06/18/received PY - 2004/01/28/accepted PY - 2004/7/20/pubmed PY - 2005/2/3/medline PY - 2004/7/20/entrez SP - 461 EP - 7 JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JO - Pancreatology VL - 4 IS - 5 N2 - AIMS: In chronic calcific pancreatitis of the tropics, etiology and relationship to developing diabetes mellitus are unknown. Some consider these cases a straightforward secondary type of diabetes, while others suggest selective beta-cell impairment. Testing pancreatic function, we investigated whether selective beta-cell impairment triggers diabetes associated with tropical pancreatitis. METHODS: At a Bangladeshi research institute, 8 chronic tropical pancreatitis and no diabetes mellitus subjects, 14 fibrocalculous pancreatic diabetics and 27 matched healthy controls underwent arginine (endocrine pancreatic function) and secretin (exocrine pancreatic function assessment) stimulation tests. RESULTS: All patients with clinically-diagnosed, chronic pancreatitis demonstrated pronounced exocrine pancreatic dysfunction with beta-cell functioning differing significantly between the two groups. Compared to controls, patients having tropical pancreatitis and no diabetes showed normal plasma C-peptide values at baseline and after arginine stimulation, while fibrocalculous pancreatic diabetics demonstrated a typical diabetic pattern for plasma C-peptide levels. In contrast, pancreatic alpha-cell functioning (glucagon response to arginine) was preserved in both pancreatitis groups. CONCLUSION: A preserved pancreatic alpha-cell function in diabetics with advanced chronic pancreatitis of the tropics supports the concept of two different pathogenic mechanisms, one eliciting chronic pancreatitis and the other selective pancreatic beta-cell impairment and subsequent diabetes mellitus. SN - 1424-3903 UR - https://www.unboundmedicine.com/medline/citation/15258409/Diabetes_mellitus_in_Tropical_Chronic_Pancreatitis_Is_Not_Just_a_Secondary_Type_of_Diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1424-3903(04)80058-9 DB - PRIME DP - Unbound Medicine ER -