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[Effects of hormonal replacement therapy on breast density in postmenopausal women].

Abstract

AIM

Recent studies have indicated that conventional hormonal replacement therapy (HRT) is associated with an increase in breast density. The aim of this non randomised prospective study was to evaluate the effects of HRT and Tibolone on breast density in postmenopausal women.

METHODS

The study population included 41 healthy women, who were on different HRT regimens and completed their 5-year mammographic follow-up. Before starting HRT, a baseline mammography was performed and repeated at 12-month interval during the follow-up. The patients, 41 healthy postmenopausal women, received 2 different treatments: continuous transdermal estrogen 50 microg/day plus sequential MPA 10 mg/day for 12 days at cycle (21 patients), Tibolone 2.5 mg/day (20 patients).

RESULTS

An increase in breast density was present in 25% of women receiving estrogen plus MPA. There was no mammographic breast density increase in Tibolone group; 9.5% of women receiving Tibolone showed reduced breast density. The modifications of breast density were reported during the 1st year of therapy.

CONCLUSION

These findings show that different HRT regimens have different effects on breast density. Tibolone does not significantly affect breast density, so it may be a preferable therapy for a larger group of postmenopausal women, including those with a familiar history of breast cancer and those with breast density.

Authors

, , , , , ,

Source

Minerva ginecologica 56:2 2004 Apr pg 125-30

MeSH

Breast
Estradiol
Estrogen Receptor Modulators
Estrogen Replacement Therapy
Female
Humans
Mammography
Medroxyprogesterone Acetate
Middle Aged
Norpregnenes
Postmenopause
Prospective Studies
Time Factors

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

15258540

Citation

TY - JOUR T1 - [Effects of hormonal replacement therapy on breast density in postmenopausal women]. AU - Bisanti,T, AU - Cavalieri,A P, AU - Capri,O, AU - Galoppi,P, AU - De Felice,C, AU - Porfiri,L M, AU - Perrone,G, PY - 2004/7/20/pubmed PY - 2004/9/28/medline PY - 2004/7/20/entrez SP - 125 EP - 30 JF - Minerva ginecologica JO - Minerva Ginecol VL - 56 IS - 2 N2 - AIM: Recent studies have indicated that conventional hormonal replacement therapy (HRT) is associated with an increase in breast density. The aim of this non randomised prospective study was to evaluate the effects of HRT and Tibolone on breast density in postmenopausal women. METHODS: The study population included 41 healthy women, who were on different HRT regimens and completed their 5-year mammographic follow-up. Before starting HRT, a baseline mammography was performed and repeated at 12-month interval during the follow-up. The patients, 41 healthy postmenopausal women, received 2 different treatments: continuous transdermal estrogen 50 microg/day plus sequential MPA 10 mg/day for 12 days at cycle (21 patients), Tibolone 2.5 mg/day (20 patients). RESULTS: An increase in breast density was present in 25% of women receiving estrogen plus MPA. There was no mammographic breast density increase in Tibolone group; 9.5% of women receiving Tibolone showed reduced breast density. The modifications of breast density were reported during the 1st year of therapy. CONCLUSION: These findings show that different HRT regimens have different effects on breast density. Tibolone does not significantly affect breast density, so it may be a preferable therapy for a larger group of postmenopausal women, including those with a familiar history of breast cancer and those with breast density. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/15258540/[Effects_of_hormonal_replacement_therapy_on_breast_density_in_postmenopausal_women]_ L2 - http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+50-28-2 ER -