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Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
Cell Tissue Res. 2004 Oct; 318(1):225-41.CT

Abstract

The etiologic basis of Parkinson's disease (PD), the second most common age-related neurodegenerative disorder, is unknown. Recent epidemiological and experimental studies indicate that exposure to environmental agents, including a number of agricultural chemicals, may contribute to the pathogenesis of this disorder. Animal models are important tools in experimental medical science for studying the pathogenesis and therapeutic intervention strategies of human diseases. Since many human disorders do not arise spontaneously in animals, characteristic functional changes have to be mimicked by neurotoxic agents. Recently, agricultural chemicals, when administrated systemically, have been shown to reproduce specific features of PD in rodents, thus opening new routes for the development of animal models for this disorder. In addition to a brief historical overview of the toxin-induced PD models, this study provides a detailed description of exiting models in which Parkinsonism is initiated via the exposure of animals to such agricultural chemicals as rotenone, paraquat, and maneb. Suggested neurotoxicity mechanisms of these chemicals are considered, and the major lessons learned from the analysis of pesticide-induced PD models are discussed.

Authors+Show Affiliations

Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia. uversky@hydrogen.ucsc.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15258850

Citation

Uversky, Vladimir N.. "Neurotoxicant-induced Animal Models of Parkinson's Disease: Understanding the Role of Rotenone, Maneb and Paraquat in Neurodegeneration." Cell and Tissue Research, vol. 318, no. 1, 2004, pp. 225-41.
Uversky VN. Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res. 2004;318(1):225-41.
Uversky, V. N. (2004). Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell and Tissue Research, 318(1), 225-41.
Uversky VN. Neurotoxicant-induced Animal Models of Parkinson's Disease: Understanding the Role of Rotenone, Maneb and Paraquat in Neurodegeneration. Cell Tissue Res. 2004;318(1):225-41. PubMed PMID: 15258850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. A1 - Uversky,Vladimir N, Y1 - 2004/07/16/ PY - 2004/04/13/received PY - 2004/05/28/accepted PY - 2004/7/20/pubmed PY - 2005/3/5/medline PY - 2004/7/20/entrez SP - 225 EP - 41 JF - Cell and tissue research JO - Cell Tissue Res VL - 318 IS - 1 N2 - The etiologic basis of Parkinson's disease (PD), the second most common age-related neurodegenerative disorder, is unknown. Recent epidemiological and experimental studies indicate that exposure to environmental agents, including a number of agricultural chemicals, may contribute to the pathogenesis of this disorder. Animal models are important tools in experimental medical science for studying the pathogenesis and therapeutic intervention strategies of human diseases. Since many human disorders do not arise spontaneously in animals, characteristic functional changes have to be mimicked by neurotoxic agents. Recently, agricultural chemicals, when administrated systemically, have been shown to reproduce specific features of PD in rodents, thus opening new routes for the development of animal models for this disorder. In addition to a brief historical overview of the toxin-induced PD models, this study provides a detailed description of exiting models in which Parkinsonism is initiated via the exposure of animals to such agricultural chemicals as rotenone, paraquat, and maneb. Suggested neurotoxicity mechanisms of these chemicals are considered, and the major lessons learned from the analysis of pesticide-induced PD models are discussed. SN - 0302-766X UR - https://www.unboundmedicine.com/medline/citation/15258850/Neurotoxicant_induced_animal_models_of_Parkinson's_disease:_understanding_the_role_of_rotenone_maneb_and_paraquat_in_neurodegeneration_ L2 - https://dx.doi.org/10.1007/s00441-004-0937-z DB - PRIME DP - Unbound Medicine ER -