Tags

Type your tag names separated by a space and hit enter

Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide.
World J Gastroenterol. 2004 Aug 01; 10(15):2241-4.WJ

Abstract

AIM

To determine whether Saiko-keishi-to (TJ-10), a Japanese herbal medicine, could protect liver injury induced by gut ischemia/reperfusion (I/R), and to investigate the role of NO.

METHODS

Male Wistar rats were exposed to 30-min gut ischemia followed by 60 min of reperfusion. Intravital microscopy was used to monitor leukocyte recruitment. Plasma tumor necrosis factor (TNF) levels and alanine aminotransferase (ALT) activities were measured. TJ-10 1 g/(kg.d) was intragastrically administered to rats for 7 d. A NO synthase inhibitor was administered.

RESULTS

In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF levels and ALT activities were mitigated by pretreatment with TJ-10. Pretreatment with the NO synthase inhibitor diminished the protective effects of TJ-10 on leukostasis in the liver, and the increase of plasma TNF levels and ALT activities. Pretreatment with TJ-10 increased plasma nitrite/nitrate levels.

CONCLUSION

TJ-10 attenuates the gut I/R-induced hepatic microvascular dysfunction and sequential hepatocellular injury via enhancement of NO production.

Authors+Show Affiliations

Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. yhorie@sc.itc.keio.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15259073

Citation

Horie, Yoshinori, et al. "Japanese Herbal Medicine, Saiko-keishi-to, Prevents Gut Ischemia/reperfusion-induced Liver Injury in Rats Via Nitric Oxide." World Journal of Gastroenterology, vol. 10, no. 15, 2004, pp. 2241-4.
Horie Y, Kajihara M, Mori S, et al. Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide. World J Gastroenterol. 2004;10(15):2241-4.
Horie, Y., Kajihara, M., Mori, S., Yamagishi, Y., Kimura, H., Tamai, H., Kato, S., & Ishii, H. (2004). Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide. World Journal of Gastroenterology, 10(15), 2241-4.
Horie Y, et al. Japanese Herbal Medicine, Saiko-keishi-to, Prevents Gut Ischemia/reperfusion-induced Liver Injury in Rats Via Nitric Oxide. World J Gastroenterol. 2004 Aug 1;10(15):2241-4. PubMed PMID: 15259073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide. AU - Horie,Yoshinori, AU - Kajihara,Mikio, AU - Mori,Shuka, AU - Yamagishi,Yoshiyuki, AU - Kimura,Hiroyuki, AU - Tamai,Hironao, AU - Kato,Shinzo, AU - Ishii,Hiromasa, PY - 2004/7/20/pubmed PY - 2004/9/24/medline PY - 2004/7/20/entrez SP - 2241 EP - 4 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 10 IS - 15 N2 - AIM: To determine whether Saiko-keishi-to (TJ-10), a Japanese herbal medicine, could protect liver injury induced by gut ischemia/reperfusion (I/R), and to investigate the role of NO. METHODS: Male Wistar rats were exposed to 30-min gut ischemia followed by 60 min of reperfusion. Intravital microscopy was used to monitor leukocyte recruitment. Plasma tumor necrosis factor (TNF) levels and alanine aminotransferase (ALT) activities were measured. TJ-10 1 g/(kg.d) was intragastrically administered to rats for 7 d. A NO synthase inhibitor was administered. RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF levels and ALT activities were mitigated by pretreatment with TJ-10. Pretreatment with the NO synthase inhibitor diminished the protective effects of TJ-10 on leukostasis in the liver, and the increase of plasma TNF levels and ALT activities. Pretreatment with TJ-10 increased plasma nitrite/nitrate levels. CONCLUSION: TJ-10 attenuates the gut I/R-induced hepatic microvascular dysfunction and sequential hepatocellular injury via enhancement of NO production. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/15259073/Japanese_herbal_medicine_Saiko_keishi_to_prevents_gut_ischemia/reperfusion_induced_liver_injury_in_rats_via_nitric_oxide_ L2 - https://www.wjgnet.com/1007-9327/full/v10/i15/2241.htm DB - PRIME DP - Unbound Medicine ER -