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The effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal women.
Climacteric 2004; 7(1):70-7C

Abstract

OBJECTIVE

To examine the effects of dietary isoflavone supplementation with an extract from red clover on cognitive function in postmenopausal women.

DESIGN

Thirty postmenopausal women aged greater than 60 years received either two tablets of an extract of aglycone isoflavones from red clover (each containing formononetin 25 mg, biochanin 2.5 mg and less than 1 mg of daidzein and genistein) for 6 months in a randomized, controlled clinical trial. Cognitive function tests were performed at baseline and at the end of isoflavone or placebo therapy.

RESULTS

Isoflavone supplementation was associated with an apparent improvement in block design (a test of visual-spatial intelligence) compared to placebo (isoflavone +12%, placebo -3%; p = 0.03), no improvement in verbal memory compared to an improvement on placebo (isoflavone +1%, placebo +29%; p = 0.023) and a deterioration in digit recall compared to placebo (isoflavone -6%, placebo +12%; p = 0.029). However, these findings were not statistically significant when corrections were made for potential chance findings due to multiple comparisons.

CONCLUSION

Isoflavone supplementation does not appear to have major short-term effects on cognitive function in postmenopausal women. However, further clinical trials are required to determine whether small effects or long-term effects on cognitive function occur during isoflavone supplementation.

Authors+Show Affiliations

Department of Clinical Pharmacology, St. George Hospital, UNSW, Kogarah, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15259285

Citation

Howes, J B., et al. "The Effects of Dietary Supplementation With Isoflavones From Red Clover On Cognitive Function in Postmenopausal Women." Climacteric : the Journal of the International Menopause Society, vol. 7, no. 1, 2004, pp. 70-7.
Howes JB, Bray K, Lorenz L, et al. The effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal women. Climacteric. 2004;7(1):70-7.
Howes, J. B., Bray, K., Lorenz, L., Smerdely, P., & Howes, L. G. (2004). The effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal women. Climacteric : the Journal of the International Menopause Society, 7(1), pp. 70-7.
Howes JB, et al. The Effects of Dietary Supplementation With Isoflavones From Red Clover On Cognitive Function in Postmenopausal Women. Climacteric. 2004;7(1):70-7. PubMed PMID: 15259285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal women. AU - Howes,J B, AU - Bray,K, AU - Lorenz,L, AU - Smerdely,P, AU - Howes,L G, PY - 2004/7/21/pubmed PY - 2004/9/24/medline PY - 2004/7/21/entrez SP - 70 EP - 7 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 7 IS - 1 N2 - OBJECTIVE: To examine the effects of dietary isoflavone supplementation with an extract from red clover on cognitive function in postmenopausal women. DESIGN: Thirty postmenopausal women aged greater than 60 years received either two tablets of an extract of aglycone isoflavones from red clover (each containing formononetin 25 mg, biochanin 2.5 mg and less than 1 mg of daidzein and genistein) for 6 months in a randomized, controlled clinical trial. Cognitive function tests were performed at baseline and at the end of isoflavone or placebo therapy. RESULTS: Isoflavone supplementation was associated with an apparent improvement in block design (a test of visual-spatial intelligence) compared to placebo (isoflavone +12%, placebo -3%; p = 0.03), no improvement in verbal memory compared to an improvement on placebo (isoflavone +1%, placebo +29%; p = 0.023) and a deterioration in digit recall compared to placebo (isoflavone -6%, placebo +12%; p = 0.029). However, these findings were not statistically significant when corrections were made for potential chance findings due to multiple comparisons. CONCLUSION: Isoflavone supplementation does not appear to have major short-term effects on cognitive function in postmenopausal women. However, further clinical trials are required to determine whether small effects or long-term effects on cognitive function occur during isoflavone supplementation. SN - 1369-7137 UR - https://www.unboundmedicine.com/medline/citation/15259285/The_effects_of_dietary_supplementation_with_isoflavones_from_red_clover_on_cognitive_function_in_postmenopausal_women_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -