Tags

Type your tag names separated by a space and hit enter

Ratio of omega-6 to omega-3 fatty acids and childhood asthma.
J Asthma 2004; 41(3):319-26JA

Abstract

Asthma is a leading cause of morbidity for children and is a major public health problem in Australia. Ecological and temporal data suggest that dietary factors may have a role in recent increases in the prevalence of asthma.

AIM

The aim of conducting this study was to investigate whether childhood asthma was associated with the ratio of omega 6 (n-6) to omega 3 (n-3) fatty acids in the diet (n-6:n-3).

METHOD

The Western Australian Pregnancy Cohort Study is a prospective birth cohort of 2602 children. Using a nested case-control cross-sectional study design within this cohort, a group of children were identified as cases with current asthma at 6 or at 8 years of age or as controls with no asthma at 6 or at 8 years. Dietary details including n-6 and n-3 fatty acid intake data were collected by parent response to a questionnaire when the children were 8 years old. Logistical regression was used to compare quartiles of n-6:n-3 intake in cases and controls. Adjustment was made for covariates: gender, gestational age, breastfeeding, older siblings, maternal smoking during pregnancy, maternal age, maternal asthma, child's current age in months, body mass index, total energy intake, and antioxidant intake (vitamins A, C, E, and zinc).

RESULTS

A response rate of 83% was achieved by providing complete data from 335 children [49% cases with current asthma (n = 166), 51% controls (n = 169)]. Following adjustment for covariates the association between the ratio of n-6:n-3 fatty acids and risk for current asthma was statistically significant (p = 0.022).

CONCLUSION

We found evidence for a modulatory effect of the dietary n-6:n-3 fatty acid ratio on the presence of asthma in children. Our results provide evidence that promotion of a diet with increased n-3 fatty acids and reduced n-6 fatty acids to protect children against symptoms of asthma is warranted.

Authors+Show Affiliations

Department of Nutrition, Dietetics and Food Science, Curtin University of Technology, Perth, Western Australia, Australia. wendyo@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15260465

Citation

Oddy, W H., et al. "Ratio of Omega-6 to Omega-3 Fatty Acids and Childhood Asthma." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 41, no. 3, 2004, pp. 319-26.
Oddy WH, de Klerk NH, Kendall GE, et al. Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J Asthma. 2004;41(3):319-26.
Oddy, W. H., de Klerk, N. H., Kendall, G. E., Mihrshahi, S., & Peat, J. K. (2004). Ratio of omega-6 to omega-3 fatty acids and childhood asthma. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 41(3), pp. 319-26.
Oddy WH, et al. Ratio of Omega-6 to Omega-3 Fatty Acids and Childhood Asthma. J Asthma. 2004;41(3):319-26. PubMed PMID: 15260465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ratio of omega-6 to omega-3 fatty acids and childhood asthma. AU - Oddy,W H, AU - de Klerk,N H, AU - Kendall,G E, AU - Mihrshahi,S, AU - Peat,J K, PY - 2004/7/21/pubmed PY - 2004/8/6/medline PY - 2004/7/21/entrez SP - 319 EP - 26 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 41 IS - 3 N2 - UNLABELLED: Asthma is a leading cause of morbidity for children and is a major public health problem in Australia. Ecological and temporal data suggest that dietary factors may have a role in recent increases in the prevalence of asthma. AIM: The aim of conducting this study was to investigate whether childhood asthma was associated with the ratio of omega 6 (n-6) to omega 3 (n-3) fatty acids in the diet (n-6:n-3). METHOD: The Western Australian Pregnancy Cohort Study is a prospective birth cohort of 2602 children. Using a nested case-control cross-sectional study design within this cohort, a group of children were identified as cases with current asthma at 6 or at 8 years of age or as controls with no asthma at 6 or at 8 years. Dietary details including n-6 and n-3 fatty acid intake data were collected by parent response to a questionnaire when the children were 8 years old. Logistical regression was used to compare quartiles of n-6:n-3 intake in cases and controls. Adjustment was made for covariates: gender, gestational age, breastfeeding, older siblings, maternal smoking during pregnancy, maternal age, maternal asthma, child's current age in months, body mass index, total energy intake, and antioxidant intake (vitamins A, C, E, and zinc). RESULTS: A response rate of 83% was achieved by providing complete data from 335 children [49% cases with current asthma (n = 166), 51% controls (n = 169)]. Following adjustment for covariates the association between the ratio of n-6:n-3 fatty acids and risk for current asthma was statistically significant (p = 0.022). CONCLUSION: We found evidence for a modulatory effect of the dietary n-6:n-3 fatty acid ratio on the presence of asthma in children. Our results provide evidence that promotion of a diet with increased n-3 fatty acids and reduced n-6 fatty acids to protect children against symptoms of asthma is warranted. SN - 0277-0903 UR - https://www.unboundmedicine.com/medline/citation/15260465/Ratio_of_omega_6_to_omega_3_fatty_acids_and_childhood_asthma_ L2 - http://www.tandfonline.com/doi/full/10.1081/jas-120026089 DB - PRIME DP - Unbound Medicine ER -