Tags

Type your tag names separated by a space and hit enter

Effects of chronic administration of antihypertensive drugs on vasodilation mediated by calcitonin gene-related peptide-containing vasodilator nerves in spontaneously hypertensive rats.
Clin Exp Pharmacol Physiol. 1992 Aug; 19(8):569-73.CE

Abstract

1. The effects of chronic administration of antihypertensive drugs on the vasodilator response mediated by calcitonin gene-related peptide (CGRP)-containing nerves were investigated in spontaneously hypertensive rats (SHR). 2. A 7 week period of antihypertensive treatment with captopril, nicardipine or propranolol during the developmental phase (8-15 weeks of age) significantly lowered the mean blood pressure of SHR when compared with non-treated SHR. 3. The mesenteric vascular beds isolated from SHR, which were chronically administered with captopril, propranolol or nicardipine, were perfused with Krebs' solution containing 7 mumol/L methoxamine to produce active tone and 5 mumol/L guanethidine to block adrenergic neurotransmission. 4. In the mesenteric vascular bed with active tone, perivascular nerve stimulation (PNS; 0.5-8 Hz) caused a frequency-dependent vasodilator response that was abolished by 100 nmol/L tetrodotoxin (neurotoxin) or 1 mumol/L CGRP (8-37), a CGRP receptor antagonist. 5. CGRP-containing nerve-mediated vasodilator responses were significantly greater in captopril-treated SHR and significantly smaller in nicardipine-treated SHR than in non-treated SHR. There was no difference between the response between propranolol-treated SHR and non-treated SHR. 6. These results suggest that chronic treatment with captopril reverses the reduced neurogenic vasodilation mediated by CGRP-containing nerves in SHR.

Authors+Show Affiliations

Department of Pharmacology, Miyazaki Medical College, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1526062

Citation

Kawasaki, H. "Effects of Chronic Administration of Antihypertensive Drugs On Vasodilation Mediated By Calcitonin Gene-related Peptide-containing Vasodilator Nerves in Spontaneously Hypertensive Rats." Clinical and Experimental Pharmacology & Physiology, vol. 19, no. 8, 1992, pp. 569-73.
Kawasaki H. Effects of chronic administration of antihypertensive drugs on vasodilation mediated by calcitonin gene-related peptide-containing vasodilator nerves in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1992;19(8):569-73.
Kawasaki, H. (1992). Effects of chronic administration of antihypertensive drugs on vasodilation mediated by calcitonin gene-related peptide-containing vasodilator nerves in spontaneously hypertensive rats. Clinical and Experimental Pharmacology & Physiology, 19(8), 569-73.
Kawasaki H. Effects of Chronic Administration of Antihypertensive Drugs On Vasodilation Mediated By Calcitonin Gene-related Peptide-containing Vasodilator Nerves in Spontaneously Hypertensive Rats. Clin Exp Pharmacol Physiol. 1992;19(8):569-73. PubMed PMID: 1526062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chronic administration of antihypertensive drugs on vasodilation mediated by calcitonin gene-related peptide-containing vasodilator nerves in spontaneously hypertensive rats. A1 - Kawasaki,H, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 569 EP - 73 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 19 IS - 8 N2 - 1. The effects of chronic administration of antihypertensive drugs on the vasodilator response mediated by calcitonin gene-related peptide (CGRP)-containing nerves were investigated in spontaneously hypertensive rats (SHR). 2. A 7 week period of antihypertensive treatment with captopril, nicardipine or propranolol during the developmental phase (8-15 weeks of age) significantly lowered the mean blood pressure of SHR when compared with non-treated SHR. 3. The mesenteric vascular beds isolated from SHR, which were chronically administered with captopril, propranolol or nicardipine, were perfused with Krebs' solution containing 7 mumol/L methoxamine to produce active tone and 5 mumol/L guanethidine to block adrenergic neurotransmission. 4. In the mesenteric vascular bed with active tone, perivascular nerve stimulation (PNS; 0.5-8 Hz) caused a frequency-dependent vasodilator response that was abolished by 100 nmol/L tetrodotoxin (neurotoxin) or 1 mumol/L CGRP (8-37), a CGRP receptor antagonist. 5. CGRP-containing nerve-mediated vasodilator responses were significantly greater in captopril-treated SHR and significantly smaller in nicardipine-treated SHR than in non-treated SHR. There was no difference between the response between propranolol-treated SHR and non-treated SHR. 6. These results suggest that chronic treatment with captopril reverses the reduced neurogenic vasodilation mediated by CGRP-containing nerves in SHR. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/1526062/Effects_of_chronic_administration_of_antihypertensive_drugs_on_vasodilation_mediated_by_calcitonin_gene_related_peptide_containing_vasodilator_nerves_in_spontaneously_hypertensive_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0305-1870&date=1992&volume=19&issue=8&spage=569 DB - PRIME DP - Unbound Medicine ER -