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Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon.
Fitoterapia. 2004 Jul; 75(5):451-6.F

Abstract

A new benzophenone, named rhizoctonic acid (1), together with three known compounds monomethylsulochrin (2), ergosterol (3) and 3beta,5alpha,6beta-trihydroxyergosta-7,22-diene (4) were isolated through bioassay-guided fractionations from the culture of Rhizoctonia sp. (Cy064), an endophytic fungus in the leaf of Cynodon dactylon. The structure of the new acid 1 was elucidated to be 5-hydroxy-2-(2-hydroxy-6-methoxy-4-methylbenzoyl)-3-methoxybenzoic acid by a combination of spectral analyses. Furthermore, the structure of monomethylsulochrin 2 was confirmed by 13C-NMR analysis. All four metabolites were subjected to a more detailed in vitro assessment of their antibacterial action against five clinically isolated and one reference (ATCC 43504) Helicobacter pylori strains.

Authors+Show Affiliations

Ma YM
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Li Y
No affiliation info available
Liu JY
No affiliation info available
Song YC
No affiliation info available
Tan RX
No affiliation info available

MeSH

Anti-Infective AgentsCynodonHelicobacter pyloriHumansMicrobial Sensitivity TestsPhytotherapyPlant LeavesRhizoctonia

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15261382

Citation

Ma, Y M., et al. "Anti-Helicobacter Pylori Metabolites From Rhizoctonia Sp. Cy064, an Endophytic Fungus in Cynodon Dactylon." Fitoterapia, vol. 75, no. 5, 2004, pp. 451-6.
Ma YM, Li Y, Liu JY, et al. Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon. Fitoterapia. 2004;75(5):451-6.
Ma, Y. M., Li, Y., Liu, J. Y., Song, Y. C., & Tan, R. X. (2004). Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon. Fitoterapia, 75(5), 451-6.
Ma YM, et al. Anti-Helicobacter Pylori Metabolites From Rhizoctonia Sp. Cy064, an Endophytic Fungus in Cynodon Dactylon. Fitoterapia. 2004;75(5):451-6. PubMed PMID: 15261382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon. AU - Ma,Y M, AU - Li,Y, AU - Liu,J Y, AU - Song,Y C, AU - Tan,R X, PY - 2003/09/24/received PY - 2004/03/31/accepted PY - 2004/7/21/pubmed PY - 2004/8/27/medline PY - 2004/7/21/entrez SP - 451 EP - 6 JF - Fitoterapia JO - Fitoterapia VL - 75 IS - 5 N2 - A new benzophenone, named rhizoctonic acid (1), together with three known compounds monomethylsulochrin (2), ergosterol (3) and 3beta,5alpha,6beta-trihydroxyergosta-7,22-diene (4) were isolated through bioassay-guided fractionations from the culture of Rhizoctonia sp. (Cy064), an endophytic fungus in the leaf of Cynodon dactylon. The structure of the new acid 1 was elucidated to be 5-hydroxy-2-(2-hydroxy-6-methoxy-4-methylbenzoyl)-3-methoxybenzoic acid by a combination of spectral analyses. Furthermore, the structure of monomethylsulochrin 2 was confirmed by 13C-NMR analysis. All four metabolites were subjected to a more detailed in vitro assessment of their antibacterial action against five clinically isolated and one reference (ATCC 43504) Helicobacter pylori strains. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/15261382/Anti_Helicobacter_pylori_metabolites_from_Rhizoctonia_sp__Cy064_an_endophytic_fungus_in_Cynodon_dactylon_ DB - PRIME DP - Unbound Medicine ER -